Published May 24, 2019 | Version v1
Publication Open

The Complex Interactions Between Obesity, Metabolism and the Brain

Creators

  • 1. Universidad Nacional del Sur
  • 2. Consejo Nacional de Investigaciones Científicas y Técnicas
  • 3. Pennington Biomedical Research Center
  • 4. Louisiana State University System

Description

Obesity is increasing at unprecedented levels globally, and the overall impact of obesity on the various organ systems of the body is only beginning to be fully appreciated. Because of the myriad of direct and indirect effects of obesity causing dysfunction of multiple tissues and organs, it is likely that there will be heterogeneity in the presentation of obesity effects in any given population. Taken together, these realities make it increasingly difficult to understand the complex interplay between obesity effects on different organs, including the brain. The focus of this review is to provide a comprehensive view of metabolic disturbances present in obesity, their direct and indirect effects on the different organ systems of the body, and to discuss the interaction of these effects in the context of brain aging and the development of neurodegenerative diseases.

⚠️ This is an automatic machine translation with an accuracy of 90-95%

Translated Description (Arabic)

تتزايد السمنة بمستويات غير مسبوقة على مستوى العالم، وقد بدأ تقدير التأثير العام للسمنة على أنظمة الأعضاء المختلفة في الجسم بشكل كامل. بسبب عدد لا يحصى من الآثار المباشرة وغير المباشرة للسمنة التي تسبب خللاً في الأنسجة والأعضاء المتعددة، فمن المحتمل أن يكون هناك عدم تجانس في ظهور آثار السمنة في أي مجموعة سكانية معينة. مجتمعة، تجعل هذه الحقائق من الصعب بشكل متزايد فهم التفاعل المعقد بين تأثيرات السمنة على الأعضاء المختلفة، بما في ذلك الدماغ. تركز هذه المراجعة على تقديم رؤية شاملة للاضطرابات الأيضية الموجودة في السمنة وتأثيراتها المباشرة وغير المباشرة على أجهزة الجسم المختلفة، ومناقشة تفاعل هذه التأثيرات في سياق شيخوخة الدماغ وتطور الأمراض التنكسية العصبية.

Translated Description (French)

L'obésité augmente à des niveaux sans précédent dans le monde, et l'impact global de l'obésité sur les différents systèmes organiques du corps commence seulement à être pleinement apprécié. En raison de la myriade d'effets directs et indirects de l'obésité provoquant un dysfonctionnement de plusieurs tissus et organes, il est probable qu'il y aura une hétérogénéité dans la présentation des effets de l'obésité dans une population donnée. Prises ensemble, ces réalités rendent de plus en plus difficile la compréhension de l'interaction complexe entre les effets de l'obésité sur différents organes, y compris le cerveau. L'objectif de cette revue est de fournir une vision globale des perturbations métaboliques présentes dans l'obésité, de leurs effets directs et indirects sur les différents systèmes organiques du corps, et de discuter de l'interaction de ces effets dans le contexte du vieillissement cérébral et du développement de maladies neurodégénératives.

Translated Description (Spanish)

La obesidad está aumentando a niveles sin precedentes a nivel mundial, y el impacto general de la obesidad en los diversos sistemas de órganos del cuerpo apenas comienza a apreciarse por completo. Debido a la gran cantidad de efectos directos e indirectos de la obesidad que causan la disfunción de múltiples tejidos y órganos, es probable que haya heterogeneidad en la presentación de los efectos de la obesidad en cualquier población. En conjunto, estas realidades hacen que sea cada vez más difícil comprender la compleja interacción entre los efectos de la obesidad en diferentes órganos, incluido el cerebro. El objetivo de esta revisión es proporcionar una visión integral de las alteraciones metabólicas presentes en la obesidad, sus efectos directos e indirectos en los diferentes sistemas orgánicos del cuerpo, y discutir la interacción de estos efectos en el contexto del envejecimiento cerebral y el desarrollo de enfermedades neurodegenerativas.

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Additional details

Additional titles

Translated title (Arabic)
التفاعلات المعقدة بين السمنة والتمثيل الغذائي والدماغ
Translated title (French)
Les interactions complexes entre l'obésité, le métabolisme et le cerveau
Translated title (Spanish)
Las complejas interacciones entre la obesidad, el metabolismo y el cerebro

Identifiers

Other
https://openalex.org/W2945556908
DOI
10.3389/fnins.2019.00513

Is supplement to
https://openalex.org/W4382631096 (Other)
https://openalex.org/W4381470518 (Other)
https://openalex.org/W4313341288 (Other)
https://openalex.org/W3209564489 (Other)
https://openalex.org/W3116387307 (Other)
https://openalex.org/W2352311653 (Other)
https://openalex.org/W2019858852 (Other)
https://openalex.org/W2013517412 (Other)
https://openalex.org/W198362155 (Other)
https://openalex.org/W1561062786 (Other)

GreSIS Basics Section

Is Global South Knowledge
Yes
Country
Argentina

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