Published January 1, 2017
| Version v1
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Adipokine Contribution to the Pathogenesis of Osteoarthritis
Creators
- 1. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
Description
Recent studies have shown that overweight and obesity play an important role in the development of osteoarthritis (OA). However, joint overload is not the only risk factor in this disease. For instance, the presence of OA in non-weight-bearing joints such as the hand suggests that metabolic factors may also contribute to its pathogenesis. Recently, white adipose tissue (WAT) has been recognized not only as an energy reservoir but also as an important secretory organ of adipokines. In this regard, adipokines have been closely associated with obesity and also play an important role in bone and cartilage homeostasis. Furthermore, drugs such as rosuvastatin or rosiglitazone have demonstrated chondroprotective and anti-inflammatory effects in cartilage explants from patients with OA. Thus, it seems that adipokines are important factors linking obesity, adiposity, and inflammation in OA. In this review, we are focused on establishing the physiological mechanisms of adipokines on cartilage homeostasis and evaluating their role in the pathophysiology of OA based on evidence derived from experimental research as well as from clinical-epidemiological studies.
Translated Descriptions
⚠️
This is an automatic machine translation with an accuracy of 90-95%
Translated Description (Arabic)
أظهرت الدراسات الحديثة أن زيادة الوزن والسمنة تلعبان دورًا مهمًا في تطور الفصال العظمي (OA). ومع ذلك، فإن الحمل الزائد للمفاصل ليس عامل الخطر الوحيد في هذا المرض. على سبيل المثال، يشير وجود OA في المفاصل غير الحاملة للوزن مثل اليد إلى أن العوامل الأيضية قد تساهم أيضًا في التسبب في المرض. في الآونة الأخيرة، تم التعرف على الأنسجة الدهنية البيضاء (WAT) ليس فقط كمستودع للطاقة ولكن أيضًا كعضو إفرازي مهم للأديبوكينات. في هذا الصدد، ارتبطت الأديبوكينات ارتباطًا وثيقًا بالسمنة وتلعب أيضًا دورًا مهمًا في توازن العظام والغضاريف. علاوة على ذلك، أظهرت أدوية مثل روزوفاستاتين أو روزيغليتازون تأثيرات واقية من الغضروف ومضادة للالتهابات في انفصال الغضروف من المرضى الذين يعانون من هشاشة العظام. وبالتالي، يبدو أن الأديبوكينات هي عوامل مهمة تربط السمنة والسمنة والالتهاب في OA. في هذه المراجعة، نركز على إنشاء الآليات الفسيولوجية للأديبوكينات على توازن الغضروف وتقييم دورها في الفيزيولوجيا المرضية لـ OA بناءً على الأدلة المستمدة من الأبحاث التجريبية وكذلك من الدراسات السريرية الوبائية.Translated Description (French)
Des études récentes ont montré que le surpoids et l'obésité jouent un rôle important dans le développement de l'arthrose (OA). Cependant, la surcharge articulaire n'est pas le seul facteur de risque de cette maladie. Par exemple, la présence d'arthrose dans les articulations non portantes telles que la main suggère que des facteurs métaboliques peuvent également contribuer à sa pathogenèse. Récemment, le tissu adipeux blanc (WAT) a été reconnu non seulement comme un réservoir d'énergie, mais aussi comme un organe sécrétoire important des adipokines. À cet égard, les adipokines ont été étroitement associées à l'obésité et jouent également un rôle important dans l'homéostasie osseuse et cartilagineuse. De plus, des médicaments tels que la rosuvastatine ou la rosiglitazone ont démontré des effets chondroprotecteurs et anti-inflammatoires dans les explants cartilagineux de patients atteints d'arthrose. Ainsi, il semble que les adipokines soient des facteurs importants reliant l'obésité, l'adiposité et l'inflammation dans l'arthrose. Dans cette revue, nous nous concentrons sur l'établissement des mécanismes physiologiques des adipokines sur l'homéostasie cartilagineuse et l'évaluation de leur rôle dans la physiopathologie de l'arthrose sur la base de preuves issues de recherches expérimentales ainsi que d'études cliniques-épidémiologiques.Translated Description (Spanish)
Estudios recientes han demostrado que el sobrepeso y la obesidad juegan un papel importante en el desarrollo de la osteoartritis (OA). Sin embargo, la sobrecarga articular no es el único factor de riesgo en esta enfermedad. Por ejemplo, la presencia de OA en articulaciones que no soportan peso, como la mano, sugiere que los factores metabólicos también pueden contribuir a su patogénesis. Recientemente, el tejido adiposo blanco (WAT) ha sido reconocido no solo como un reservorio de energía, sino también como un importante órgano secretor de adipocinas. En este sentido, las adipocinas se han asociado estrechamente con la obesidad y también desempeñan un papel importante en la homeostasis ósea y cartilaginosa. Además, fármacos como la rosuvastatina o la rosiglitazona han demostrado efectos condroprotectores y antiinflamatorios en explantes de cartílago de pacientes con OA. Por lo tanto, parece que las adipocinas son factores importantes que vinculan la obesidad, la adiposidad y la inflamación en la OA. En esta revisión, nos centramos en establecer los mecanismos fisiológicos de las adipocinas en la homeostasis del cartílago y evaluar su papel en la fisiopatología de la OA a partir de la evidencia derivada de la investigación experimental, así como de estudios clínico-epidemiológicos.Files
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Additional details
Additional titles
- Translated title (Arabic)
- مساهمة الأديبوكين في التسبب في الفصال العظمي
- Translated title (French)
- Adipokine Contribution à la pathogenèse de l'arthrose
- Translated title (Spanish)
- Contribución de las adipoquinas a la patogénesis de la osteoartritis
Identifiers
- Other
- https://openalex.org/W2604812123
- DOI
- 10.1155/2017/5468023
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