Published November 16, 2018 | Version v1
Publication Open

Two new monoterpenoid indole alkaloids from <i>Tabernaemontana divaricata</i>

Creators

  • 1. Yunnan University of Traditional Chinese Medicine
  • 2. Kunming Institute of Botany
  • 3. Chinese Academy of Sciences

Description

Two new monoterpenoid indole alkaloids, tabervarines A (1) and B (2), along with seven known monoterpenoid indole alkaloids, were isolated from the methanol extract of the twigs and leaves of Tabernaemontana divaricata. The structures including the absolute configurations of the new alkaloids were elucidated based on MS, NMR, and ECD calculation. The in vitro cytotoxic activities of the isolated alkaloids against several human cancer cell lines were also evaluated.

⚠️ This is an automatic machine translation with an accuracy of 90-95%

Translated Description (Arabic)

تم عزل قلوين جديدين من قلويدات الإندول أحادية التربينويد، التابرفارين A (1) و B (2)، جنبًا إلى جنب مع سبعة قلويدات معروفة من قلويدات الإندول أحادية التربينويد، من مستخلص الميثانول من أغصان وأوراق تابيرنايمونتانا ديفاريكاتا. تم توضيح الهياكل بما في ذلك التكوينات المطلقة للقلويدات الجديدة بناءً على حساب MS و NMR و ECD. كما تم تقييم الأنشطة السامة للخلايا في المختبر للقلويدات المعزولة ضد العديد من خطوط الخلايا السرطانية البشرية.

Translated Description (English)

Two new monoterpenoid indole alkaloids, tabervarines A (1) and B (2), along with seven known monoterpenoid indole alkaloids, were isolated from the methanol extract of the twigs and leaves of Tabernaemontana divaricata. The structures including the absolute configurations of the new alkaloids were elucidated based on MS, NMR, and ECD calculation. The in vitro cytotoxic activities of the isolated alkaloids against several human cancer cell lines were also evaluated.

Translated Description (French)

Two new monoterpenoid indole alkaloids, tabervarines A (1) and B (2), along with seven known monoterpenoid indole alkaloids, were isolated from the methanol extract of the twigs and leaves of Tabernaemontana divaricata. The structures including the absolute configurations of the new alkaloids were elucidated based on MS, NMR, and ECD calculation. The in vitro cytotoxic activities of the isolated alkaloids against several human cancer cell lines were also evaluated.

Translated Description (Spanish)

Two new monoterpenoid indole alkaloids, tabervarines A (1) and B (2), along with seven known monoterpenoid indole alkaloids, were isolated from the methanol extract of the twigs and leaves of Tabernaemontana divaricata. The structures including the absolute configurations of the new alkaloids were elucidated based on MS, NMR, and ECD calculation. The in vitro cytotoxic activities of the isolated alkaloids against several human cancer cell lines were also evaluated.

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Additional details

Additional titles

Translated title (Arabic)
قلوانيتان جديدتان من قلويدات الإندول أحادية التوربين من <i>Tabernaemontana divaricata</i>
Translated title (English)
Two new monoterpenoid indole alkaloids from <i>Tabernaemontana divaricata</i>
Translated title (French)
Two new monoterpenoid indole alkaloids from <i>Tabernaemontana divaricata</i>
Translated title (Spanish)
Two new monoterpenoid indole alkaloids from <i>Tabernaemontana divaricata</i>

Identifiers

Other
https://openalex.org/W2901654493
DOI
10.1080/14786419.2018.1488707

Is supplement to
https://openalex.org/W4310243805 (Other)
https://openalex.org/W3011485570 (Other)
https://openalex.org/W2952675974 (Other)
https://openalex.org/W2932071515 (Other)
https://openalex.org/W2139472749 (Other)
https://openalex.org/W2064909778 (Other)
https://openalex.org/W2044915178 (Other)
https://openalex.org/W1995313040 (Other)
https://openalex.org/W1971138718 (Other)
https://openalex.org/W1966766789 (Other)

GreSIS Basics Section

Is Global South Knowledge
Yes
Country
China

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