Published August 7, 2020 | Version v1
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Phyto-Immunotherapy, a Complementary Therapeutic Option to Decrease Metastasis and Attack Breast Cancer Stem Cells

Creators

  • 1. Pontificia Universidad Javeriana

Description

In this review, we report on the complexity of BCSCs as key cells in the emergence of a chemoresistant tumor phenotype, and as a result, the appearance of distant metastasis in breast cancer patients. The search for mechanisms that increase sensitivity to chemotherapy and also allow activation of the tumor-specific immune response is of high priority. As we observed throughout this review, natural products isolated or in standardized extracts, such as P2Et or others, could act synergistically, increasing tumor sensitivity to chemotherapy, recovering the tumor microenvironment, and participating in the induction of a specific immune response, which in the end would lead to the destruction of CSCs and the decrease in metastasis.

⚠️ This is an automatic machine translation with an accuracy of 90-95%

Translated Description (Arabic)

في هذه المراجعة، نبلغ عن تعقيد BCSCs كخلايا رئيسية في ظهور النمط الظاهري للورم المقاوم للكيماويات، ونتيجة لذلك، ظهور النقائل البعيدة في مرضى سرطان الثدي. إن البحث عن الآليات التي تزيد من الحساسية للعلاج الكيميائي وتسمح أيضًا بتنشيط الاستجابة المناعية الخاصة بالورم هو أمر ذو أولوية عالية. كما لاحظنا طوال هذه المراجعة، يمكن أن تعمل المنتجات الطبيعية المعزولة أو في مستخلصات موحدة، مثل P2Et أو غيرها، بشكل تآزري، مما يزيد من حساسية الورم للعلاج الكيميائي، ويستعيد البيئة الدقيقة للورم، ويشارك في تحريض استجابة مناعية محددة، مما يؤدي في النهاية إلى تدمير CSCs وانخفاض في الانبثاث.

Translated Description (French)

Dans cette revue, nous rapportons la complexité des BCSC en tant que cellules clés dans l'émergence d'un phénotype tumoral chimiorésistant et, par conséquent, l'apparition de métastases à distance chez les patientes atteintes d'un cancer du sein. La recherche de mécanismes qui augmentent la sensibilité à la chimiothérapie et permettent également l'activation de la réponse immunitaire spécifique à la tumeur est hautement prioritaire. Comme nous l'avons observé tout au long de cette revue, les produits naturels isolés ou dans des extraits standardisés, tels que P2Et ou autres, pourraient agir en synergie, augmentant la sensibilité tumorale à la chimiothérapie, récupérant le microenvironnement tumoral et participant à l'induction d'une réponse immunitaire spécifique, ce qui conduirait finalement à la destruction des CSC et à la diminution des métastases.

Translated Description (Spanish)

En esta revisión, informamos sobre la complejidad de las BCSC como células clave en la aparición de un fenotipo tumoral quimiorresistente y, como resultado, la aparición de metástasis a distancia en pacientes con cáncer de mama. La búsqueda de mecanismos que aumenten la sensibilidad a la quimioterapia y también permitan la activación de la respuesta inmune específica del tumor es de alta prioridad. Como observamos a lo largo de esta revisión, los productos naturales aislados o en extractos estandarizados, como P2Et u otros, podrían actuar sinérgicamente, aumentando la sensibilidad del tumor a la quimioterapia, recuperando el microambiente tumoral y participando en la inducción de una respuesta inmune específica, que al final conduciría a la destrucción de las CSC y a la disminución de la metástasis.

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Additional details

Additional titles

Translated title (Arabic)
العلاج المناعي النباتي، خيار علاجي تكميلي لتقليل الانبثاث ومهاجمة الخلايا الجذعية لسرطان الثدي
Translated title (French)
La phyto-immunothérapie, une option thérapeutique complémentaire pour diminuer les métastases et attaquer les cellules souches du cancer du sein
Translated title (Spanish)
Fitoinmunoterapia, una opción terapéutica complementaria para disminuir la metástasis y atacar a las células madre del cáncer de mama

Identifiers

Other
https://openalex.org/W3044416854
DOI
10.3389/fonc.2020.01334

Is supplement to
https://openalex.org/W4366290863 (Other)
https://openalex.org/W4322720888 (Other)
https://openalex.org/W4307869277 (Other)
https://openalex.org/W4296613612 (Other)
https://openalex.org/W4200022043 (Other)
https://openalex.org/W3193904228 (Other)
https://openalex.org/W3109885192 (Other)
https://openalex.org/W2884525857 (Other)
https://openalex.org/W2112727616 (Other)
https://openalex.org/W2030161097 (Other)

GreSIS Basics Section

Is Global South Knowledge
Yes
Country
Colombia

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