Published February 1, 2022 | Version v1
Publication Metadata-only

New insights on mucormycosis and its association with the COVID-19 pandemic

Creators

  • 1. Ain Shams University
  • 2. King Khalid University

Description

COVID-19 continues to cause significant fatality worldwide. Glucocorticoids prove to play essential roles in COVID-19 management; however, the extensive use of steroids together with the virus immune dysregulation may increase the danger of secondary infections with mucormycosis, an angioinvasive fungal infection. Unfortunately, a definite correlation between COVID-19 and elevated mucormycosis infection cases is now clear worldwide. In this review, we discuss the historical record and epidemiology of mucormycosis as well as pathogenesis and associated host immune response, risk factors, clinical presentation, diagnosis and treatment. Special emphasis is given to its association with the current COVID-19 pandemic, including latest updates on COVID-19-associated mucormycosis cases globally, with recommendations for efficacious management.

⚠️ This is an automatic machine translation with an accuracy of 90-95%

Translated Description (Arabic)

لا يزال كوفيد-19 يسبب وفيات كبيرة في جميع أنحاء العالم. أثبتت الكورتيكويدات السكرية أنها تلعب أدوارًا أساسية في إدارة COVID -19 ؛ ومع ذلك، فإن الاستخدام المكثف للستيرويدات مع خلل التنظيم المناعي للفيروس قد يزيد من خطر العدوى الثانوية بالفطريات المخاطية، وهي عدوى فطرية باضعة في الأوعية الدموية. لسوء الحظ، أصبح الارتباط المؤكد بين COVID -19 وحالات الإصابة بالفطريات المخاطية المرتفعة واضحًا الآن في جميع أنحاء العالم. في هذه المراجعة، نناقش السجل التاريخي وعلم الأوبئة للفطريات المخاطية وكذلك التسبب في الأمراض والاستجابة المناعية للمضيف المرتبطة بها وعوامل الخطر والعرض السريري والتشخيص والعلاج. يتم التركيز بشكل خاص على ارتباطه بجائحة COVID -19 الحالية، بما في ذلك آخر التحديثات حول حالات الفطريات المخاطية المرتبطة بـ COVID -19 على مستوى العالم، مع توصيات للإدارة الفعالة.

Translated Description (French)

La COVID-19 continue de causer des décès importants dans le monde entier. Les glucocorticoïdes s'avèrent jouer un rôle essentiel dans la gestion de la COVID-19 ; cependant, l'utilisation intensive de stéroïdes associée à la dérégulation immunitaire virale peut augmenter le risque d'infections secondaires avec mucormycose, une infection fongique angioinvasive. Malheureusement, une corrélation nette entre le COVID-19 et les cas élevés d'infection par la mucormycose est maintenant claire dans le monde entier. Dans cette revue, nous discutons des antécédents et de l'épidémiologie de la mucormycose ainsi que de la pathogenèse et de la réponse immunitaire de l'hôte associée, des facteurs de risque, de la présentation clinique, du diagnostic et du traitement. Un accent particulier est mis sur son association avec la pandémie actuelle de COVID-19, y compris les dernières mises à jour sur les cas de mucormycose associés à la COVID-19 dans le monde, avec des recommandations pour une gestion efficace.

Translated Description (Spanish)

El COVID-19 sigue causando muertes significativas en todo el mundo. Los glucocorticoides demuestran desempeñar un papel esencial en el manejo de la COVID-19; sin embargo, el uso extensivo de esteroides junto con la desregulación inmune del virus puede aumentar el peligro de infecciones secundarias con mucormicosis, una infección fúngica angioinvasiva. Desafortunadamente, ahora está clara una correlación definitiva entre COVID-19 y casos elevados de infección por mucormicosis en todo el mundo. En esta revisión, discutimos el registro histórico y la epidemiología de la mucormicosis, así como la patogénesis y la respuesta inmune del huésped asociada, los factores de riesgo, la presentación clínica, el diagnóstico y el tratamiento. Se hace especial hincapié en su asociación con la actual pandemia de COVID-19, incluidas las últimas actualizaciones sobre los casos de mucormicosis asociada a COVID-19 en todo el mundo, con recomendaciones para un tratamiento eficaz.

Additional details

Additional titles

Translated title (Arabic)
رؤى جديدة حول الفطريات المخاطية وارتباطها بجائحة كوفيد-19
Translated title (French)
Nouvelles perspectives sur la mucormycose et son association avec la pandémie de COVID-19
Translated title (Spanish)
Nuevos conocimientos sobre la mucormicosis y su asociación con la pandemia de COVID-19

Identifiers

Other
https://openalex.org/W4200169110
DOI
10.2144/fsoa-2021-0122

Is supplement to
https://openalex.org/W4378976089 (Other)
https://openalex.org/W4320713087 (Other)
https://openalex.org/W4312609735 (Other)
https://openalex.org/W4298759308 (Other)
https://openalex.org/W3198067377 (Other)
https://openalex.org/W3049423424 (Other)
https://openalex.org/W2351100964 (Other)
https://openalex.org/W2098392329 (Other)
https://openalex.org/W2068695218 (Other)
https://openalex.org/W2052720155 (Other)

GreSIS Basics Section

Is Global South Knowledge
Yes
Country
Egypt

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