Published December 12, 2017 | Version v1
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ADVERSE EFFECTS OF LINCOMYCIN AND SPECTINOMYCIN IN RATS

Creators

  • 1. Mansoura University

Description

This study was performed to investigate the adverse effects of lincomycin (given orally at 500 mg/kg daily for 21 days) and spectinomycin (given S.C at 250 mg/kg daily for 30 days) on 24 apparently clinically healthy adult male albino rats (175 - 250 gm). Blood, serum and tissues (Liver, kidney and testis) samples were collected for hematological, biochemical and histopathological for investigation. The obtained results revealed that, lincomycin and spectinomycin treated groups showed a significant decrease in total erythrocytic and leucocytic count (especially lymphocytes), hemoglobin values and PCV value. The levels of ALT, AST, cholesterol, triglycerides and LDL revealed a significant increase in lincomycin and spectinomycin treated groups. While the level of HDL showed a significant decrease in both lincomycin and spectinomycin treated groups. The results also showed that, both drugs induced histopathological alterations in the liver, kidney and testis.

⚠️ This is an automatic machine translation with an accuracy of 90-95%

Translated Description (Arabic)

تم إجراء هذه الدراسة للتحقيق في الآثار السلبية للينكومايسين (يعطى عن طريق الفم بمعدل 500 ملغم/كغم يوميًا لمدة 21 يومًا) وسيكتينومايسين (يعطى S.C بمعدل 250 ملغم/كغم يوميًا لمدة 30 يومًا) على 24 فأرًا أمهق بالغًا يتمتع بصحة سريرية (175 - 250 جم). تم جمع عينات الدم والمصل والأنسجة (الكبد والكلى والخصية) للفحص الدموي والكيميائي الحيوي والهيستوباثولوجي. كشفت النتائج التي تم الحصول عليها أن المجموعات المعالجة باللينكومايسين والسيكتينومايسين أظهرت انخفاضًا كبيرًا في إجمالي عدد كريات الدم الحمراء والكريات البيضاء (خاصة الخلايا الليمفاوية) وقيم الهيموغلوبين وقيمة PCV. كشفت مستويات ALT و AST والكوليسترول والدهون الثلاثية و LDL عن زيادة كبيرة في المجموعات المعالجة باللينكومايسين والسيكتينومايسين. بينما أظهر مستوى HDL انخفاضًا كبيرًا في كل من المجموعات المعالجة باللينكومايسين والسيكتينومايسين. وأظهرت النتائج أيضًا أن كلا العقارين يسببان تغيرات في الأنسجة المرضية في الكبد والكلى والخصية.

Translated Description (English)

This study was performed to investigate the adverse effects of lincomycin (given orally at 500 mg/kg daily for 21 days) and spectinomycin (given S.C at 250 mg/kg daily for 30 days) on 24 apparently clinically healthy adult male albino rats (175 - 250 gm). Blood, serum and tissues (liver, kidney and testis) samples were collected for hematological, biochemical and histopathological investigation. The obtained results revealed that lincomycin and spectinomycin treated groups showed a significant decrease in total erythrocytic and leucocytic count (especially lymphocytes), hemoglobin values and PCV value. The levels of ALT, AST, cholesterol, triglycerides and LDL revealed a significant increase in lincomycin and spectinomycin treated groups. While the level of HDL showed a significant decrease in both lincomycin and spectinomycin treated groups. The results also showed that, both drugs induced histopathological alterations in the liver, kidney and testis.

Translated Description (French)

This study was performed to investigate the adverse effects of lincomycin (given orally at 500 mg/kg daily for 21 days) and spectinomycin (given S.C at 250 mg/kg daily for 30 days) on 24 apparently clinically healthy adult male albino rats (175 - 250 gm). Des échantillons de sang, de sérum et de tissus (foie, rein et testicules) ont été collectés pour des études hématologiques, biochimiques et histopathologiques. The obtained results revealed that, lincomycin and spectinomycin treated groups showed a significant decrease in total erythrocytic and leucocytic count (especially lymphocytes), hémoglobine values and PCV value. The levels of ALT, AST, cholesterol, triglycerides and LDL revealed a significativement increase in lincomycin and spectinomycin treated groups. While the level of HDL showed a significant decrease in both lincomycin and spectinomycin treated groups. The results also showed that, both drugs induced histopathological alterations in the liver, kidney and testis.

Translated Description (Spanish)

This study was performed to investigate the adverse effects of lincomycin (given orally at 500 mg/kg daily for 21 days) and spectinomycin (given S.C at 250 mg/kg daily for 30 days) on 24 apparently clinically healthy adult male albino rats (175 - 250 gm). Blood, serum and tissues (Liver, kidney and testis) samples were collected for hematological, biochemical and histopathological for investigation. The obtained results revealed that, lincomycin and spectinomycin treated groups showed a significant decrease in total erythrocytic and leucocytic count (especially lymphocytes), hemoglobin values and PCV value. Los niveles de ALT, AST, colesterol, triglicéridos y LDL revelaron un aumento significativo en los grupos tratados con lincomicina y espectinomicina. While the level of HDL showed a significant decrease in both lincomycin and spectinomycin treated groups. The results also showed that, both drugs induced histopathological alterations in the liver, kidney and testis.

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Additional details

Additional titles

Translated title (Arabic)
الآثار الضارة للينكومايسين وسيكتينومايسين في الفئران
Translated title (English)
ADVERSE EFFECTS OF LINCOMYCIN AND SPECTINOMYCIN IN RAT
Translated title (French)
EFFETS INDÉSIRABLES DE LA LINCOMYCINE ET DE LA SPECTINOMYCINE DANS LES RATS
Translated title (Spanish)
EFECTOS ADVERSOS DE LA LINCOMICINA Y LA ESPECTINOMICINA EN RATAS

Identifiers

Other
https://openalex.org/W3193252336
DOI
10.21608/mvmj.2017.127611

Is supplement to
https://openalex.org/W4247850374 (Other)
https://openalex.org/W2407459955 (Other)
https://openalex.org/W2353253238 (Other)
https://openalex.org/W2316850937 (Other)
https://openalex.org/W2114791159 (Other)
https://openalex.org/W2096636627 (Other)
https://openalex.org/W2088837804 (Other)
https://openalex.org/W2060150245 (Other)
https://openalex.org/W1998443431 (Other)
https://openalex.org/W1580282864 (Other)

GreSIS Basics Section

Is Global South Knowledge
Yes
Country
Egypt

References

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  • https://openalex.org/W2138745304
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