Published September 7, 2020 | Version v1
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GENE EXPRESSION PATTERN ANALYSIS FOR FORENSIC DIAGNOSIS OF SUDDEN CARDIAC DEATH

Creators

  • 1. Calcutta National Medical College and Hospital

Description

Diagnosis of Sudden cardiac death (SCD) is challenging for forensic experts. In the current scenario, genetic analysis is rapidly gaining interest in forensic science. Previous studies are not only limited to using protein markers. In this regard, analysis of mRNA is also a key feature. Analysing mRNA offers insight into the diseases and mechanisms leading to death. It can also be used for forensic diagnostic purposes. This review article takes the help of this methodology to discuss about those mRNA species that can aid in the process of sudden cardiac death (SCD) diagnosis. These are mRNA encoding Heat Shock Protein (HSP), mRNA encoding Hemoglobin A1/2 & B, mRNA encoding Pyruvate Dehydrogenase (PDK4), mRNAs encoding Connexin 43 (Cx43) & Zonula occludens-1 (ZO1), mRNA encoding TNNI3, MYL3, TGFB1, MMP9, VEGFA and mRNA expressing Brain Natriuretic Peptide (BNP).Owing to the difficulty of diagnosing SCD, molecular markers are often developed that can aid in the process. Nowadays, mRNA is showing promising usefulness to supplement the process. Keywords: Sudden Cardiac Death, forensic, gene expression

⚠️ This is an automatic machine translation with an accuracy of 90-95%

Translated Description (Arabic)

يمثل تشخيص الموت القلبي المفاجئ (SCD) تحديًا لخبراء الطب الشرعي. في السيناريو الحالي، يكتسب التحليل الجيني اهتمامًا سريعًا بعلوم الطب الشرعي. لا تقتصر الدراسات السابقة على استخدام علامات البروتين فقط. في هذا الصدد، يعد تحليل الحمض النووي الريبوزي المرسال سمة رئيسية أيضًا. يقدم تحليل الحمض النووي الريبوزي المرسال نظرة ثاقبة للأمراض والآليات التي تؤدي إلى الوفاة. يمكن استخدامه أيضًا لأغراض التشخيص الجنائي. تستفيد مقالة المراجعة هذه من هذه المنهجية لمناقشة أنواع الحمض النووي الريبوزي المرسال التي يمكن أن تساعد في عملية تشخيص الموت القلبي المفاجئ (SCD). هذه هي mRNA ترميز بروتين الصدمة الحرارية (HSP)، mRNA ترميز الهيموغلوبين A1/2 و B، mRNA ترميز نازعة هيدروجين البيروفات (PDK4)، mRNAs ترميز Connexin 43 (Cx43) و Zonula occludens -1 (ZO1)، mRNA ترميز TNNI3، MYL3، TGFB1، MMP9، VEGFA و mRNA التعبير عن ببتيد ناتريوتريك الدماغ (BNP) .بالنظر إلى صعوبة تشخيص SCD، غالبًا ما يتم تطوير العلامات الجزيئية التي يمكن أن تساعد في هذه العملية. في الوقت الحاضر، يظهر الحمض النووي الريبوزي المرسال فائدة واعدة لاستكمال العملية. الكلمات المفتاحية: الموت القلبي المفاجئ، الطب الشرعي، التعبير الجيني

Translated Description (English)

Diagnosis of sudden cardiac death (SCD) is challenging for forensic experts. In the current scenario, genetic analysis is rapidly gaining interest in forensic science. Previous studies are not only limited to using protein markers. In this regard, analysis of mRNA is also a key feature. Analysing mRNA offers insight into the diseases and mechanisms leading to death. It can also be used for forensic diagnostic purposes. This review article takes the help of this methodology to discuss about those mRNA species that can aid in the process of sudden cardiac death (SCD) diagnosis. These are mRNA encoding Heat Shock Protein (HSP), mRNA encoding Hemoglobin A1/2 & B, mRNA encoding Pyruvate Dehydrogenase (PDK4), mRNAs encoding Connexin 43 (Cx43) & Zonula occludens-1 (ZO1), mRNA encoding TNNI3, MYL3, TGFB1, MMP9, VEGFA and mRNA expressing Brain Natriuretic Peptide (BNP).Owing to the difficulty of diagnosing SCD, molecular markers are often developed that can aid in the process. Nowadays, mRNA is showing promising usefulness to supplement the process. Keywords: Sudden Cardiac Death, forensic, gene expression

Translated Description (French)

Diagnostic of Sudden cardiac death (SCD) is challenging for for forensic experts. Dans le scénario actuel, l'analyse génétique gagne rapidement de l'intérêt pour la science médico-légale. Les études précédentes ne sont pas seulement limitées à l'utilisation de marqueurs protéiques. Dans ce regard, l'analyse de l'ARNm est également une caractéristique clé. Analyser les offres d'ARNm insight into the diseases and mechanisms leading to death. Il peut donc être utilisé à des fins de diagnostic médico-légal. Cette revue article takes the help of this methodology to discuss about those mRNA species that can aid in the process of sudden cardiac death (SCD) diagnosis. These are mRNA encoding Heat Shock Protein (HSP), mRNA encoding Hemoglobine A1/2 & B, mRNA encoding Pyruvate Dehydrogenase (PDK4), mRNAs encoding Connexin 43 (Cx43) & Zonula occludens-1 (ZO1), mRNA encoding TNNI3, MYL3, TGFB1, MMP9, VEGFA and mRNA expressing Brain Natriuretic Peptide (BNP).Owing to the problemulty of diagnosing SCD, molecular markers are often developed that can aid in the process. Nowadays, mRNA is showing promising usefulness to supplement the process. Mots-clés : mort subite cardiaque, médico-légale, expression génétique

Translated Description (Spanish)

El diagnóstico de la muerte cardíaca súbita (SCD) es un desafío para los expertos forenses. En el escenario actual, el análisis genético es un interés de ganancia rápida en la ciencia forense. Previous Studies are not only limited to using protein markers. In this regard, analysis of mRNA is also a key feature. Analysing mRNA offers insight into the diseases and mechanisms leading to death. It can also be used for for forensic diagnosis purposes. Este artículo de revisión toma la ayuda de esta metodología para discutir sobre las especies de ARNm que pueden ayudar en el proceso de diagnóstico de la muerte cardíaca súbita (SCD). These are mRNA encoding Heat Shock Protein (HSP), mRNA encoding Hemoglobin A1/2 & B, mRNA encoding Pyruvate Dehydrogenase (PDK4), mRNAs encoding Connexin 43 (Cx43) & Zonula occludens-1 (ZO1), mRNA encoding TNNI3, MYL3, TGFB1, MMP9, VEGFA and mRNA expressing Brain Natriuretic Peptide (BNP).Owing to the difficulty of diagnosis SCD, molecular markers are often developed that can aid in the process. Nowadays, mRNA is showing promising usefulness to supplement the process. Palabras clave: muerte cardíaca súbita, forense, expresión génica

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Additional details

Additional titles

Translated title (Arabic)
تحليل نمط التعبير الجيني للتشخيص الجنائي للوفاة القلبية المفاجئة
Translated title (English)
GENE EXPRESSION PATTERN ANALYSIS FOR FORENSIC DIAGNOSIS OF SUDDEN CARDIAC DEATH
Translated title (French)
ANALYSE DES MOTIFS D'EXPRESSION GENETIQUE POUR LE DIAGNOSTIC MÉDICO-LÉGAL DE LA MORT SUBITE CARDIAQUE
Translated title (Spanish)
GENE EXPRESSION PATTERN ANALYSIS FOR FORENSIC DIAGNOSIS OF SUDDEN CARDIAC DEATH

Identifiers

Other
https://openalex.org/W3088811094
DOI
10.32553/ijmsdr.v4i9.670

Is supplement to
https://openalex.org/W592719406 (Other)
https://openalex.org/W3189205251 (Other)
https://openalex.org/W2129393568 (Other)
https://openalex.org/W2072511358 (Other)
https://openalex.org/W2048994687 (Other)
https://openalex.org/W2003534681 (Other)
https://openalex.org/W1969841472 (Other)
https://openalex.org/W182146997 (Other)
https://openalex.org/W171196056 (Other)
https://openalex.org/W1490665129 (Other)

GreSIS Basics Section

Is Global South Knowledge
Yes
Country
India

References

  • https://openalex.org/W1982070989
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