Published October 26, 2022 | Version v1
Publication Metadata-only

Novel Preclinical Study of Galloylquinic Acid Compounds from <i>Copaifera lucens</i> with Potent Antifungal Activity against Vaginal Candidiasis Induced in a Murine Model via Multitarget Modes of Action

Creators

  • 1. Tanta University
  • 2. Institute for Research in Biomedicine
  • 3. Delta University for Science and Technology
  • 4. Harvard University
  • 5. Universidade de São Paulo

Description

Our work presents a new perspective on the potential use of GQAs as safe and highly effective phytochemicals against MDR C. albicans . This microorganism colonizes the human vaginal epithelium, causing vaginal candidiasis, a condition characterized by recurrent pathogenicity and tolerance to traditional antifungal therapy.

⚠️ This is an automatic machine translation with an accuracy of 90-95%

Translated Description (Arabic)

يقدم عملنا منظورًا جديدًا حول الاستخدام المحتمل لـ GQAs كمواد كيميائية نباتية آمنة وفعالة للغاية ضد MDR C. albicans . يستعمر هذا الكائن الدقيق الظهارة المهبلية البشرية، مما يسبب داء المبيضات المهبلي، وهي حالة تتميز بالإمراض المتكرر والتسامح مع العلاج التقليدي المضاد للفطريات.

Translated Description (French)

Notre travail présente une nouvelle perspective sur l'utilisation potentielle des AQG en tant que produits phytochimiques sûrs et hautement efficaces contre C. albicans MDR. Ce micro-organisme colonise l'épithélium vaginal humain, provoquant une candidose vaginale, une affection caractérisée par une pathogénicité récurrente et une tolérance au traitement antifongique traditionnel.

Translated Description (Spanish)

Nuestro trabajo presenta una nueva perspectiva sobre el uso potencial de los GQA como fitoquímicos seguros y altamente efectivos contra la C. albicans MDR. Este microorganismo coloniza el epitelio vaginal humano, causando candidiasis vaginal, una condición caracterizada por la patogenicidad recurrente y la tolerancia a la terapia antifúngica tradicional.

Additional details

Additional titles

Translated title (Arabic)
دراسة جديدة قبل السريرية لمركبات حمض الغالويلكينيك من <i>كوبايفيرا لوسينس</i> مع نشاط مضاد للفطريات قوي ضد داء المبيضات المهبلي المستحث في نموذج مورين عبر طرق عمل متعددة الأهداف
Translated title (French)
Nouvelle étude préclinique de composés d'acide galloylquinique de <i>Copaifera lucens</i> avec une activité antifongique puissante contre la candidose vaginale induite dans un modèle murin via des modes d'action multi-cibles
Translated title (Spanish)
Nuevo estudio preclínico de compuestos de ácido galoilquínico de <i>Copaifera lucens</i> con potente actividad antifúngica contra la candidiasis vaginal inducida en un modelo murino a través de modos de acción multiobjetivo

Identifiers

Other
https://openalex.org/W4291972641
DOI
10.1128/spectrum.02724-21

Is supplement to
https://openalex.org/W4322732097 (Other)
https://openalex.org/W4244990601 (Other)
https://openalex.org/W3142860483 (Other)
https://openalex.org/W2946449973 (Other)
https://openalex.org/W2464917578 (Other)
https://openalex.org/W2384619178 (Other)
https://openalex.org/W2380086641 (Other)
https://openalex.org/W2371206802 (Other)
https://openalex.org/W2314746940 (Other)
https://openalex.org/W2202902285 (Other)

GreSIS Basics Section

Is Global South Knowledge
Yes
Country
Egypt

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