Published February 1, 2015 | Version v1
Publication Open

FEASIBILITY OF USING DIFFERENT IONIC LIQUIDS FOR THE ENZYMATIC SYNTHESIS OF AMOXICILLIN

Creators

  • 1. Brazilian Agricultural Research Corporation
  • 2. Universidade Federal de São Carlos
  • 3. Universidade Federal da Bahia
  • 4. University of Rio Grande and Rio Grande Community College
  • 5. Universidade Federal do Rio Grande do Sul

Description

Industrially, amoxicillin has been produced by chemical processes.But, the enzymatic synthesis catalyzed by penicillin G acylase (PGA, E.C.3.5.1.11)is more attractive from the environmental point of view.However, an obstacle for the industrial application of the enzymatic route is the limited product yield due to undesirable hydrolytic reactions.This drawback can be minimized by reducing water activity in the reaction medium.Ionic liquids (ILs) have emerged as an alternative to conventional organic media.This study assessed the feasibility of use of different ILs, protic (PILs) and aprotic (AILs), in the enzymatic synthesis of amoxicillin, by testing the stability of reaction substrates (6-aminopenicillanic acid and phydroxyphenylglycine methyl ester) in these solvents.These compounds were completely stable in AILs.Besides, PGA was active in AILs.In contrast, none of the evaluated PILs was inert for these substrates making unfeasible the use for this enzymatic process.

⚠️ This is an automatic machine translation with an accuracy of 90-95%

Translated Description (Arabic)

من الناحية الصناعية، تم إنتاج الأموكسيسيلين عن طريق العمليات الكيميائية. ولكن، التخليق الأنزيمي الذي يحفزه البنسلين جي أسيلاز (PGA، E.C.3.5.1.11)هو أكثر جاذبية من وجهة النظر البيئية. ومع ذلك، فإن عقبة أمام التطبيق الصناعي للطريق الأنزيمي هي العائد المحدود للمنتج بسبب التفاعلات المائية غير المرغوب فيها. يمكن تقليل هذا العيب عن طريق تقليل نشاط الماء في وسط التفاعل. ظهرت السوائل الأيونية (ILs) كبديل للوسائط العضوية التقليدية. قيمت هذه الدراسة جدوى استخدام ILs مختلفة، بروتيك (PILs) و aprotic (AILs)، في التخليق الأنزيمي للأموكسيسيلين، عن طريق اختبار استقرار ركائز التفاعل (حمض 6 - amopenicillanic و phydroxyphenylglycine methyl ester) في هذه المذيبات. كانت المركبات مستقرة تمامًا في AILs، إلى جانب PILBs. لم تكن نشطة في التباين في PILs. لم يتم تقييمها في هذه العملية غير المغذية.

Translated Description (English)

Industrially, amoxicillin has been produced by chemical processes.But, the enzymatic synthesis catalyzed by penicillin G acylase (PGA, E.C.3.5.1.11)is more attractive from the environmental point of view.However, an obstacle for the industrial application of the enzymatic route is the limited product yield due to undesirable hydrolytic reactions.This drawback can be minimized by reducing water activity in the reaction medium.Ionic liquids (ILs) have emerged as an alternative to conventional organic media.This study assessed the feasibility of use of different ILs, protic (PILs) and aprotic (AILs), in the enzymatic synthesis of amoxicillin, by testing the stability of reaction substrates (6-aminopenicillanic acid and phydroxyphenylglycine methyl ester) in these solvents.These compounds were completely stable in AILs.Besides, PGA was active in AILs.In contrast, none of the evaluated PILs was inert for these substrates making unfeasible the use for this enzymatic process.

Translated Description (French)

Industrially, amoxicillin has been produced by chemical processes.But, the enzymatic synthesis catalyzed by penicillin G acylase (PGA, E.C.3.5.1.11)is more attractive from the environmental point of view.However, an obstacle for the industrial application of the enzymatic route is the limited product yield due to undesirable hydrolytic reactions.This drawback can be minimized by reducing water activity in the reaction medium.Ionic liquids (ILs) have emerged as an alternative to conventional organic media.This study assessed the feasibility of use of different ILs, protic (PILs) and aprotic (AILs), in the enzym synthaticesis of amoxicillin, by testing the stability of reaction substrates (6-aminopenicillan acid and phydroxyphenylglycine methyl ester) in solhents.

Translated Description (Spanish)

Industrially, amoxicillin has been produced by chemical processes.But, the enzymatic synthesis catalyzed by penicillin G acylase (PGA, E.C.3.5.1.11)is more attractive from the environmental point of view.However, an obstacle for the industrial application of the enzymatic route is the limited product yield due to undesirable hydrolytic reactions.This drawback can be minimized by reducing water activity in the reaction medium.Ionic liquids (ILs) have emerged as an alternative to conventional organic media.This study assessed the feasibility of use of different ILs, pro (PILs) and aprotic (AILs), in the enzymatic synthesis of amoxicillin, by testing the stability of reaction substrates (6-aminopenicilic acid and phyglyxycyl) in testerhyl methyl methys in stable. AILs, in the enzymatic synthesis of amoxicillin, by the enzymatic hydroly point in the reaction in the reaction medium.

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Additional details

Additional titles

Translated title (Arabic)
جدوى استخدام السوائل الأيونية المختلفة للتخليق الأنزيمي للأموكسيسيلين
Translated title (English)
FEASIBILITY OF USING DIFFERENT IONIC LIQUIDS FOR THE ENZYMATIC SYNTHESIS OF AMOXICILLIN
Translated title (French)
FEASIBILITY OF USING DIFFERENT IONIC LIQUIDES FOR THE ENZYMATIC SYNTHESIS OF AMOXICILLIN
Translated title (Spanish)
FEASIBILITY OF USING DIFFERENT IONIC LIQUIDS FOR THE ENZYMATIC SYNTHESIS OF AMOXICILLIN

Identifiers

Other
https://openalex.org/W2246783784
DOI
10.5151/chemeng-cobeq2014-1248-20264-138554

Is supplement to
https://openalex.org/W2951376330 (Other)
https://openalex.org/W2912484274 (Other)
https://openalex.org/W2352741502 (Other)
https://openalex.org/W2166530799 (Other)
https://openalex.org/W2120215589 (Other)
https://openalex.org/W2089105165 (Other)
https://openalex.org/W2074311840 (Other)
https://openalex.org/W2072536863 (Other)
https://openalex.org/W2060802469 (Other)
https://openalex.org/W2002226878 (Other)

GreSIS Basics Section

Is Global South Knowledge
Yes
Country
Brazil

References

  • https://openalex.org/W1996086823