Published January 8, 2019 | Version v1
Publication Open

Some Prospective Alternatives for Treating Pain: The Endocannabinoid System and Its Putative Receptors GPR18 and GPR55

Creators

  • 1. Autonomous University of Aguascalientes
  • 2. The University of Texas at Dallas
  • 3. Universidad Nacional Autónoma de México
  • 4. Consejo Nacional de Humanidades, Ciencias y Tecnologías
  • 5. Center for Research and Advanced Studies of the National Polytechnic Institute

Description

Background: Marijuana extracts (cannabinoids) have been used for several millennia for pain treatment. Regarding the site of action, cannabinoids are highly promiscuous molecules, but only two cannabinoid receptors (CB1 and CB2) have been deeply studied and classified. Thus, therapeutic actions, side effects and pharmacological targets for cannabinoids have been explained based on the pharmacology of cannabinoid CB1/CB2 receptors. However, the accumulation of confusing and sometimes contradictory results suggests the existence of other cannabinoid receptors. Different orphan proteins (e.g., GPR18, GPR55, GPR119, etc.) have been proposed as putative cannabinoid receptors. According to their expression, GPR18 and GPR55 could be involved in sensory transmission and pain integration. Methods: This article reviews select relevant information about the potential role of GPR18 and GPR55 in the pathophysiology of pain. Results: This work summarized novel data supporting that, besides cannabinoid CB1 and CB2 receptors, GPR18 and GPR55 may be useful for pain treatment. Conclusion: There is evidence to support an antinociceptive role for GPR18 and GPR55.

⚠️ This is an automatic machine translation with an accuracy of 90-95%

Translated Description (Arabic)

خلفية: تم استخدام مستخلصات الماريجوانا (القنب) لعدة آلاف من السنين لعلاج الألم. فيما يتعلق بموقع العمل، فإن القنب عبارة عن جزيئات شديدة الاختلاط، ولكن تم دراسة وتصنيف اثنين فقط من مستقبلات القنب (CB1 و CB2) بعمق. وبالتالي، تم شرح الإجراءات العلاجية والآثار الجانبية والأهداف الدوائية للقنب بناءً على علم الأدوية لمستقبلات القنب CB1/CB2. ومع ذلك، فإن تراكم النتائج المربكة والمتناقضة في بعض الأحيان يشير إلى وجود مستقبلات أخرى للقنب. تم اقتراح بروتينات يتيمة مختلفة (على سبيل المثال، GPR18، GPR55، GPR119، إلخ) كمستقبلات مفترضة للقنب. وفقًا لتعبيراتهم، يمكن أن يشارك GPR18 و GPR55 في الانتقال الحسي وتكامل الألم. الطرق: تستعرض هذه المقالة المعلومات المحددة ذات الصلة حول الدور المحتمل لـ GPR18 و GPR55 في الفيزيولوجيا المرضية للألم. النتائج: لخص هذا العمل بيانات جديدة تدعم أنه إلى جانب مستقبلات القنب CB1 و CB2، قد يكون GPR18 و GPR55 مفيدين لعلاج الألم. الاستنتاج: هناك أدلة تدعم دورًا مضادًا لاستقبال GPR18 و GPR55.

Translated Description (French)

Contexte : Les extraits de marijuana (cannabinoïdes) sont utilisés depuis plusieurs millénaires pour le traitement de la douleur. En ce qui concerne le site d'action, les cannabinoïdes sont des molécules très promiscuistes, mais seuls deux récepteurs cannabinoïdes (CB1 et CB2) ont été étudiés et classés en profondeur. Ainsi, les actions thérapeutiques, les effets secondaires et les cibles pharmacologiques des cannabinoïdes ont été expliqués sur la base de la pharmacologie des récepteurs cannabinoïdes CB1/CB2. Cependant, l'accumulation de résultats confus et parfois contradictoires suggère l'existence d'autres récepteurs cannabinoïdes. Différentes protéines orphelines (par exemple, GPR18, GPR55, GPR119, etc.) ont été proposées comme récepteurs cannabinoïdes présumés. Selon leur expression, GPR18 et GPR55 pourraient être impliqués dans la transmission sensorielle et l'intégration de la douleur. Méthodes : Cet article passe en revue certaines informations pertinentes sur le rôle potentiel de GPR18 et GPR55 dans la physiopathologie de la douleur. Résultats : Ce travail a résumé de nouvelles données soutenant que, outre les récepteurs cannabinoïdes CB1 et CB2, GPR18 et GPR55 peuvent être utiles pour le traitement de la douleur. Conclusion : Il existe des preuves à l'appui d'un rôle antinociceptif pour GPR18 et GPR55.

Translated Description (Spanish)

Antecedentes: Los extractos de marihuana (cannabinoides) se han utilizado durante varios milenios para el tratamiento del dolor. En cuanto al sitio de acción, los cannabinoides son moléculas altamente promiscuas, pero solo dos receptores cannabinoides (CB1 y CB2) han sido profundamente estudiados y clasificados. Por lo tanto, las acciones terapéuticas, los efectos secundarios y los objetivos farmacológicos de los cannabinoides se han explicado en función de la farmacología de los receptores cannabinoides CB1/CB2. Sin embargo, la acumulación de resultados confusos y a veces contradictorios sugiere la existencia de otros receptores cannabinoides. Se han propuesto diferentes proteínas huérfanas (por ejemplo, GPR18, GPR55, GPR119, etc.) como supuestos receptores cannabinoides. Según su expresión, GPR18 y GPR55 podrían estar involucrados en la transmisión sensorial y la integración del dolor. Métodos: Este artículo revisa información relevante seleccionada sobre el papel potencial de GPR18 y GPR55 en la fisiopatología del dolor. Resultados: Este trabajo resumió datos novedosos que respaldan que, además de los receptores cannabinoides CB1 y CB2, GPR18 y GPR55 pueden ser útiles para el tratamiento del dolor. Conclusión: Existe evidencia que respalda un papel antinociceptivo para GPR18 y GPR55.

Files

pdf.pdf

Files (1.6 MB)

⚠️ Please wait a few minutes before your translated files are ready ⚠️ Note: Some files might be protected thus translations might not work.
Name Size Download all
md5:90665ebf956bfb0e1feeb2227c0ddb95
1.6 MB
Preview Download

Additional details

Additional titles

Translated title (Arabic)
بعض البدائل المحتملة لعلاج الألم: نظام Endocannabinoid ومستقبلاته الافتراضية GPR18 و GPR55
Translated title (French)
Quelques alternatives potentielles pour traiter la douleur : le système endocannabinoïde et ses récepteurs putatifs GPR18 et GPR55
Translated title (Spanish)
Algunas posibles alternativas para tratar el dolor: el sistema endocannabinoide y sus supuestos receptores GPR18 y GPR55

Identifiers

Other
https://openalex.org/W2910414836
DOI
10.3389/fphar.2018.01496

Is supplement to
https://openalex.org/W2910414836 (Other)
https://openalex.org/W2800510547 (Other)
https://openalex.org/W2318941457 (Other)
https://openalex.org/W2163573952 (Other)
https://openalex.org/W2088747854 (Other)
https://openalex.org/W2020887015 (Other)
https://openalex.org/W2007485514 (Other)
https://openalex.org/W2002785222 (Other)
https://openalex.org/W1966146877 (Other)
https://openalex.org/W132433771 (Other)

GreSIS Basics Section

Is Global South Knowledge
Yes
Country
Mexico

References

  • https://openalex.org/W1235781926
  • https://openalex.org/W1488329806
  • https://openalex.org/W1500005891
  • https://openalex.org/W1504900766
  • https://openalex.org/W1512361956
  • https://openalex.org/W1542482240
  • https://openalex.org/W1550617675
  • https://openalex.org/W1550699885
  • https://openalex.org/W1565584672
  • https://openalex.org/W1570565174
  • https://openalex.org/W1578820780
  • https://openalex.org/W1591647183
  • https://openalex.org/W1594786713
  • https://openalex.org/W1607638275
  • https://openalex.org/W1645449597
  • https://openalex.org/W1819429514
  • https://openalex.org/W1831769215
  • https://openalex.org/W1844090762
  • https://openalex.org/W1867335213
  • https://openalex.org/W1883044208
  • https://openalex.org/W1887249759
  • https://openalex.org/W1896430056
  • https://openalex.org/W1907921830
  • https://openalex.org/W1926578427
  • https://openalex.org/W1963739241
  • https://openalex.org/W1964037009
  • https://openalex.org/W1965823643
  • https://openalex.org/W1967922769
  • https://openalex.org/W1968426375
  • https://openalex.org/W1968446992
  • https://openalex.org/W1968459206
  • https://openalex.org/W1968714225
  • https://openalex.org/W1969628982
  • https://openalex.org/W1971081736
  • https://openalex.org/W1971400025
  • https://openalex.org/W1971909322
  • https://openalex.org/W1973289150
  • https://openalex.org/W1974642601
  • https://openalex.org/W1976768202
  • https://openalex.org/W1977183025
  • https://openalex.org/W1977768357
  • https://openalex.org/W1978828934
  • https://openalex.org/W1978931409
  • https://openalex.org/W1979963836
  • https://openalex.org/W1979990272
  • https://openalex.org/W1980502203
  • https://openalex.org/W1980612820
  • https://openalex.org/W1982029344
  • https://openalex.org/W1987613482
  • https://openalex.org/W1987729666
  • https://openalex.org/W1989073099
  • https://openalex.org/W1989263093
  • https://openalex.org/W1989814102
  • https://openalex.org/W1991001962
  • https://openalex.org/W1991319303
  • https://openalex.org/W1991497324
  • https://openalex.org/W1992217371
  • https://openalex.org/W1994513849
  • https://openalex.org/W1994956270
  • https://openalex.org/W1995474168
  • https://openalex.org/W1995552285
  • https://openalex.org/W1995669176
  • https://openalex.org/W1996295130
  • https://openalex.org/W1997001171
  • https://openalex.org/W1997940254
  • https://openalex.org/W1998106503
  • https://openalex.org/W1998108076
  • https://openalex.org/W1999212252
  • https://openalex.org/W1999405426
  • https://openalex.org/W2000154529
  • https://openalex.org/W2003404396
  • https://openalex.org/W2003555425
  • https://openalex.org/W2004468399
  • https://openalex.org/W2004848791
  • https://openalex.org/W2005180409
  • https://openalex.org/W2006081951
  • https://openalex.org/W2006878320
  • https://openalex.org/W2007715028
  • https://openalex.org/W2008426814
  • https://openalex.org/W2009383738
  • https://openalex.org/W2009738204
  • https://openalex.org/W2009968727
  • https://openalex.org/W2013460111
  • https://openalex.org/W2015263236
  • https://openalex.org/W2015601936
  • https://openalex.org/W2015734868
  • https://openalex.org/W2016078643
  • https://openalex.org/W2016122949
  • https://openalex.org/W2016482675
  • https://openalex.org/W2017538187
  • https://openalex.org/W2018469929
  • https://openalex.org/W2018479387
  • https://openalex.org/W2018655546
  • https://openalex.org/W2018656586
  • https://openalex.org/W2020010905
  • https://openalex.org/W2020241617
  • https://openalex.org/W2021105586
  • https://openalex.org/W2022429405
  • https://openalex.org/W2022683321
  • https://openalex.org/W2022819833
  • https://openalex.org/W2024083629
  • https://openalex.org/W2024653583
  • https://openalex.org/W2024836296
  • https://openalex.org/W2027484549
  • https://openalex.org/W2027610254
  • https://openalex.org/W2027905133
  • https://openalex.org/W2028253575
  • https://openalex.org/W2028458837
  • https://openalex.org/W2028633707
  • https://openalex.org/W2028855866
  • https://openalex.org/W2029468394
  • https://openalex.org/W2030986287
  • https://openalex.org/W2033158772
  • https://openalex.org/W2033931579
  • https://openalex.org/W2034509002
  • https://openalex.org/W2036912145
  • https://openalex.org/W2037208185
  • https://openalex.org/W2037314052
  • https://openalex.org/W2037811574
  • https://openalex.org/W2038174618
  • https://openalex.org/W2038288674
  • https://openalex.org/W2039257552
  • https://openalex.org/W2043303731
  • https://openalex.org/W204416320
  • https://openalex.org/W2044289811
  • https://openalex.org/W2044609482
  • https://openalex.org/W2044659508
  • https://openalex.org/W2045665112
  • https://openalex.org/W2046678517
  • https://openalex.org/W2047936607
  • https://openalex.org/W2049204635
  • https://openalex.org/W2050022483
  • https://openalex.org/W2050833893
  • https://openalex.org/W2052715846
  • https://openalex.org/W2053807417
  • https://openalex.org/W2054154014
  • https://openalex.org/W2054697305
  • https://openalex.org/W2056188558
  • https://openalex.org/W2056785650
  • https://openalex.org/W2057468498
  • https://openalex.org/W2057515228
  • https://openalex.org/W2061169432
  • https://openalex.org/W2061926221
  • https://openalex.org/W2064803709
  • https://openalex.org/W2065728462
  • https://openalex.org/W2066111582
  • https://openalex.org/W2066159223
  • https://openalex.org/W2067301830
  • https://openalex.org/W2067385623
  • https://openalex.org/W2069638092
  • https://openalex.org/W2069895337
  • https://openalex.org/W2070535004
  • https://openalex.org/W2071384116
  • https://openalex.org/W2071942614
  • https://openalex.org/W2071991061
  • https://openalex.org/W2072297942
  • https://openalex.org/W2072840386
  • https://openalex.org/W2073050255
  • https://openalex.org/W2073546439
  • https://openalex.org/W2074342222
  • https://openalex.org/W2075213391
  • https://openalex.org/W2075715972
  • https://openalex.org/W2075850029
  • https://openalex.org/W2076861026
  • https://openalex.org/W2077358692
  • https://openalex.org/W2077365895
  • https://openalex.org/W2078030320
  • https://openalex.org/W2078196652
  • https://openalex.org/W2080649553
  • https://openalex.org/W2081629704
  • https://openalex.org/W2082237701
  • https://openalex.org/W2082252301
  • https://openalex.org/W2082433795
  • https://openalex.org/W2082759547
  • https://openalex.org/W2083316585
  • https://openalex.org/W2084190290
  • https://openalex.org/W2084445932
  • https://openalex.org/W2085741941
  • https://openalex.org/W2085884412
  • https://openalex.org/W2087674201
  • https://openalex.org/W2089180001
  • https://openalex.org/W2089478925
  • https://openalex.org/W2090722957
  • https://openalex.org/W2092971703
  • https://openalex.org/W2094735736
  • https://openalex.org/W2096338979
  • https://openalex.org/W2096529235
  • https://openalex.org/W2102089125
  • https://openalex.org/W2103289578
  • https://openalex.org/W2103477492
  • https://openalex.org/W2103513615
  • https://openalex.org/W2108130675
  • https://openalex.org/W2108650133
  • https://openalex.org/W2108879539
  • https://openalex.org/W2110625766
  • https://openalex.org/W2111389428
  • https://openalex.org/W2112026566
  • https://openalex.org/W2112755850
  • https://openalex.org/W2113377040
  • https://openalex.org/W2114826780
  • https://openalex.org/W2115754584
  • https://openalex.org/W2120227293
  • https://openalex.org/W2130303934
  • https://openalex.org/W2135115921
  • https://openalex.org/W2136399145
  • https://openalex.org/W2137788707
  • https://openalex.org/W2138357748
  • https://openalex.org/W2138684513
  • https://openalex.org/W2139407741
  • https://openalex.org/W2142741697
  • https://openalex.org/W2143684129
  • https://openalex.org/W2143970752
  • https://openalex.org/W2145508348
  • https://openalex.org/W2145724426
  • https://openalex.org/W2146647122
  • https://openalex.org/W2147095527
  • https://openalex.org/W2147672258
  • https://openalex.org/W2149045366
  • https://openalex.org/W2149363030
  • https://openalex.org/W2149796309
  • https://openalex.org/W2151109262
  • https://openalex.org/W2152329429
  • https://openalex.org/W2157286501
  • https://openalex.org/W2163573952
  • https://openalex.org/W2165128851
  • https://openalex.org/W2165381235
  • https://openalex.org/W2166017636
  • https://openalex.org/W2166669754
  • https://openalex.org/W2167149788
  • https://openalex.org/W2170556110
  • https://openalex.org/W2210741139
  • https://openalex.org/W2252424676
  • https://openalex.org/W2278610020
  • https://openalex.org/W2296986887
  • https://openalex.org/W2313492890
  • https://openalex.org/W2324311973
  • https://openalex.org/W2338549928
  • https://openalex.org/W2342265050
  • https://openalex.org/W2412646938
  • https://openalex.org/W2420777177
  • https://openalex.org/W2433306471
  • https://openalex.org/W2501047946
  • https://openalex.org/W2514023866
  • https://openalex.org/W2516378834
  • https://openalex.org/W2558614687
  • https://openalex.org/W2577694949
  • https://openalex.org/W2586362005
  • https://openalex.org/W2587336651
  • https://openalex.org/W2605767320
  • https://openalex.org/W2612116413
  • https://openalex.org/W2619425927
  • https://openalex.org/W2623056148
  • https://openalex.org/W2732639757
  • https://openalex.org/W2745292704
  • https://openalex.org/W2761862301
  • https://openalex.org/W2762851710
  • https://openalex.org/W2765684626
  • https://openalex.org/W2793983403
  • https://openalex.org/W2807759151
  • https://openalex.org/W2809162727
  • https://openalex.org/W4232986912
  • https://openalex.org/W4237588022
  • https://openalex.org/W646114512
  • https://openalex.org/W82550095
  • https://openalex.org/W92495189