Published May 1, 2024 | Version v1
Publication Open

Plasmodium falciparum alters the trophoblastic barrier and stroma villi organization of human placental villi explants

Creators

  • 1. Universidad de Antioquia
  • 2. University of Chile

Description

The sequestration of Plasmodium falciparum infected erythrocytes in the placenta, and the resulting inflammatory response affects maternal and child health. Despite existing information, little is known about the direct impact of P. falciparum on the placental barrier formed by trophoblast and villous stroma. This study aimed to assess placental tissue damage caused by P. falciparum in human placental explants (HPEs).

⚠️ This is an automatic machine translation with an accuracy of 90-95%

Translated Description (Arabic)

عزل كريات الدم الحمراء المصابة بالمتصورة المنجلية في المشيمة، والاستجابة الالتهابية الناتجة تؤثر على صحة الأم والطفل. على الرغم من المعلومات الموجودة، لا يُعرف سوى القليل عن التأثير المباشر لـ P. falciparum على الحاجز المشيمي الذي تشكله الأرومة الغاذية والسدى الزغابي. تهدف هذه الدراسة إلى تقييم تلف أنسجة المشيمة الناجم عن P. falciparum في زراعة المشيمة البشرية (HPEs).

Translated Description (French)

La séquestration des érythrocytes infectés par Plasmodium falciparum dans le placenta et la réponse inflammatoire qui en résulte affectent la santé maternelle et infantile. Malgré les informations existantes, on sait peu de choses sur l'impact direct de P. falciparum sur la barrière placentaire formée par le trophoblaste et le stroma villositaire. Cette étude visait à évaluer les lésions du tissu placentaire causées par P. falciparum dans les explants placentaires humains (HPE).

Translated Description (Spanish)

El secuestro de eritrocitos infectados por Plasmodium falciparum en la placenta y la respuesta inflamatoria resultante afectan la salud materna e infantil. A pesar de la información existente, se sabe poco sobre el impacto directo de P. falciparum en la barrera placentaria formada por el trofoblasto y el estroma velloso. Este estudio tuvo como objetivo evaluar el daño al tejido placentario causado por P. falciparum en explantes placentarios humanos (HPE).

Files

s12936-024-04960-9.pdf

Files (9.1 MB)

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Additional details

Additional titles

Translated title (Arabic)
المتصورة المنجلية تغير حاجز الأرومة الغاذية وتنظم سدى الزغابات لزغابات المشيمة البشرية
Translated title (French)
Plasmodium falciparum modifie la barrière trophoblastique et l'organisation des villosités du stroma des explants de villosités placentaires humaines
Translated title (Spanish)
Plasmodium falciparum altera la barrera trofoblástica y la organización de las vellosidades del estroma de los explantes de vellosidades placentarias humanas

Identifiers

Other
https://openalex.org/W4396561847
DOI
10.1186/s12936-024-04960-9

Is supplement to
https://openalex.org/W4394932387 (Other)
https://openalex.org/W2905252089 (Other)
https://openalex.org/W2364181806 (Other)
https://openalex.org/W2360746352 (Other)
https://openalex.org/W2357192927 (Other)
https://openalex.org/W2333945011 (Other)
https://openalex.org/W2328409297 (Other)
https://openalex.org/W2278924995 (Other)
https://openalex.org/W1955580232 (Other)
https://openalex.org/W120319590 (Other)

GreSIS Basics Section

Is Global South Knowledge
Yes
Country
Colombia

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