Published April 1, 2019 | Version v1
Publication Open

Pharmacokinetic-Pharmacodynamic Assessment of the Hepatic and Bone Marrow Toxicities of the New Trypanoside Fexinidazole

Creators

  • 1. Mahidol Oxford Tropical Medicine Research Unit
  • 2. Mahidol University
  • 3. University of Oxford
  • 4. Drugs for Neglected Diseases Initiative

Description

Fexinidazole is a novel oral treatment for human African trypanosomiasis caused by Trypanosoma brucei gambiense ( g -HAT). Fexinidazole also has activity against T. cruzi , the causative agent of Chagas disease.

⚠️ This is an automatic machine translation with an accuracy of 90-95%

Translated Description (Arabic)

فيكسينيدازول هو علاج فموي جديد لداء المثقبيات الأفريقي البشري الناجم عن المثقبية البروسية الغامبية ( g - HAT). لدى فيكسينيدازول أيضًا نشاط ضد T. cruzi ، العامل المسبب لمرض شاغاس.

Translated Description (French)

Le fexinidazole est un nouveau traitement oral de la trypanosomiase africaine humaine causée par Trypanosoma brucei gambiense ( g -HAT). Le fexinidazole a également une activité contre T. cruzi , l'agent causal de la maladie de Chagas.

Translated Description (Spanish)

El fexinidazol es un tratamiento oral novedoso para la tripanosomiasis africana humana causada por Trypanosoma brucei gambiense ( g -HAT). El fexinidazol también tiene actividad contra T. cruzi , el agente causante de la enfermedad de Chagas.

Files

e02515-18.full.pdf.pdf

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Additional details

Additional titles

Translated title (Arabic)
تقييم الحرائك الدوائية والديناميكية الدوائية لسموم الكبد ونخاع العظام في المثقبيات الجديدة فيكسينيدازول
Translated title (French)
Évaluation pharmacocinétique et pharmacodynamique des toxicités hépatiques et de la moelle osseuse du nouveau trypanoside fexinidazole
Translated title (Spanish)
Evaluación farmacocinética-farmacodinámica de las toxicidades hepáticas y de la médula ósea del nuevo tripanósido fexinidazol

Identifiers

Other
https://openalex.org/W2902598833
DOI
10.1128/aac.02515-18

Is supplement to
https://openalex.org/W2992709639 (Other)
https://openalex.org/W2594910449 (Other)
https://openalex.org/W2410816841 (Other)
https://openalex.org/W2227061539 (Other)
https://openalex.org/W2108417615 (Other)
https://openalex.org/W2090099591 (Other)
https://openalex.org/W2010116591 (Other)
https://openalex.org/W2002058825 (Other)
https://openalex.org/W1997101420 (Other)
https://openalex.org/W1758514097 (Other)

GreSIS Basics Section

Is Global South Knowledge
Yes
Country
Thailand

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