Published October 10, 2021
| Version v1
Publication
Open
Cytosolic and nuclear recognition of virus and viral evasion
Creators
- 1. Ningbo First Hospital
- 2. Peking University
- 3. Zhuhai People's Hospital
- 4. Jinan University
Description
The innate immune system is the first line of host defense, which responds rapidly to viral infection. Innate recognition of viruses is mediated by a set of pattern recognition receptors (PRRs) that sense viral genomic nucleic acids and/or replication intermediates. PRRs are mainly localized either to the endosomes, the plasma membrane or the cytoplasm. Recent evidence suggested that several proteins located in the nucleus could also act as viral sensors. In turn, these important elements are becoming the target for most viruses to evade host immune surveillance. In this review, we focus on the recent progress in the study of viral recognition and evasion.
Translated Descriptions
⚠️
This is an automatic machine translation with an accuracy of 90-95%
Translated Description (Arabic)
الجهاز المناعي الفطري هو الخط الأول للدفاع عن المضيف، والذي يستجيب بسرعة للعدوى الفيروسية. يتوسط التعرف الفطري على الفيروسات مجموعة من مستقبلات التعرف على الأنماط (PRRs) التي تستشعر الأحماض النووية الجينومية الفيروسية و/أو وسيطات النسخ المتماثل. يتم توطين PRRs بشكل أساسي إما إلى الإندوسومات أو غشاء البلازما أو السيتوبلازم. تشير الأدلة الحديثة إلى أن العديد من البروتينات الموجودة في النواة يمكن أن تعمل أيضًا كمستشعرات فيروسية. في المقابل، أصبحت هذه العناصر المهمة هدفًا لمعظم الفيروسات للتهرب من المراقبة المناعية للمضيف. في هذه المراجعة، نركز على التقدم الأخير في دراسة التعرف على الفيروسات والتهرب منها.Translated Description (French)
Le système immunitaire inné est la première ligne de défense de l'hôte, qui répond rapidement à l'infection virale. La reconnaissance innée des virus est médiée par un ensemble de récepteurs de reconnaissance des formes (PRR) qui détectent les acides nucléiques génomiques viraux et/ou les intermédiaires de réplication. Les PRR sont principalement localisés soit aux endosomes, à la membrane plasmique ou au cytoplasme. Des preuves récentes suggèrent que plusieurs protéines situées dans le noyau pourraient également agir comme des capteurs viraux. À leur tour, ces éléments importants deviennent la cible de la plupart des virus pour échapper à la surveillance immunitaire de l'hôte. Dans cette revue, nous nous concentrons sur les progrès récents dans l'étude de la reconnaissance et de l'évasion virales.Translated Description (Spanish)
El sistema inmunitario innato es la primera línea de defensa del huésped, que responde rápidamente a la infección viral. El reconocimiento innato de virus está mediado por un conjunto de receptores de reconocimiento de patrones (PRR) que detectan ácidos nucleicos genómicos virales y/o productos intermedios de replicación. Los PRR se localizan principalmente en los endosomas, la membrana plasmática o el citoplasma. La evidencia reciente sugiere que varias proteínas ubicadas en el núcleo también podrían actuar como sensores virales. A su vez, estos elementos importantes se están convirtiendo en el objetivo de la mayoría de los virus para evadir la vigilancia inmunitaria del huésped. En esta revisión, nos centramos en los avances recientes en el estudio del reconocimiento y la evasión viral.Files
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Additional details
Additional titles
- Translated title (Arabic)
- التعرف الخلوي والنووي على الفيروسات والتهرب الفيروسي
- Translated title (French)
- Reconnaissance cytosolique et nucléaire du virus et évasion virale
- Translated title (Spanish)
- Reconocimiento citosólico y nuclear de virus y evasión viral
Identifiers
- Other
- https://openalex.org/W3205629769
- DOI
- 10.1186/s43556-021-00046-z
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