Published April 1, 2024 | Version v1
Publication Metadata-only

Towards a Global View of Parkinson's Disease Genetics

Creators

  • 1. National Institute of Neurological Disorders and Stroke
  • 2. National Institute on Aging
  • 3. National Institutes of Health
  • 4. Pontificia Universidad Javeriana
  • 5. Université Laval
  • 6. Tbilisi State Medical University
  • 7. University College London
  • 8. National Hospital for Neurology and Neurosurgery

Description

Parkinson's disease (PD) is a global health challenge, yet historically studies of PD have taken place predominantly in European populations. Recent genetics research conducted in non-European populations has revealed novel population-specific genetic loci linked to PD risk, highlighting the importance of studying PD globally. These insights have broadened our understanding of PD etiology, which is crucial for developing disease-modifying interventions. This review comprehensively explores the global genetic landscape of PD, emphasizing the scientific rationale for studying underrepresented populations. It underscores challenges, such as genotype-phenotype heterogeneity and inclusion difficulties for non-European participants, emphasizing the ongoing need for diverse and inclusive research in PD. ANN NEUROL 2024.

⚠️ This is an automatic machine translation with an accuracy of 90-95%

Translated Description (Arabic)

يعد مرض باركنسون (PD) تحديًا صحيًا عالميًا، ومع ذلك فقد أجريت دراسات تاريخية على مرض باركنسون في الغالب في السكان الأوروبيين. كشفت الأبحاث الوراثية الأخيرة التي أجريت على السكان غير الأوروبيين عن مواضع وراثية جديدة خاصة بالسكان مرتبطة بمخاطر مرض باركنسون، مما يسلط الضوء على أهمية دراسة مرض باركنسون على مستوى العالم. وقد وسعت هذه الرؤى من فهمنا لمسببات مرض باركنسون، وهو أمر بالغ الأهمية لتطوير التدخلات المعدلة للأمراض. تستكشف هذه المراجعة بشكل شامل المشهد الوراثي العالمي لمرض باركنسون، مع التأكيد على الأساس المنطقي العلمي لدراسة المجموعات السكانية الممثلة تمثيلاً ناقصًا. وهو يؤكد على التحديات، مثل عدم التجانس بين النمط الجيني والنمط الظاهري وصعوبات الإدماج للمشاركين غير الأوروبيين، مع التأكيد على الحاجة المستمرة إلى بحث متنوع وشامل في مرض باركنسون. آن نيورول 2024.

Translated Description (French)

La maladie de Parkinson (MP) est un problème de santé mondial, mais historiquement, les études sur la MP ont eu lieu principalement dans les populations européennes. Des recherches génétiques récentes menées dans des populations non européennes ont révélé de nouveaux loci génétiques spécifiques à une population liés au risque de maladie de Parkinson, soulignant l'importance d'étudier la maladie de Parkinson à l'échelle mondiale. Ces informations ont élargi notre compréhension de l'étiologie de la MP, qui est cruciale pour le développement d'interventions modificatrices de la maladie. Cette revue explore de manière exhaustive le paysage génétique mondial de la MP, en mettant l'accent sur la justification scientifique de l'étude des populations sous-représentées. Il souligne les défis, tels que l'hétérogénéité génotype-phénotype et les difficultés d'inclusion pour les participants non européens, soulignant la nécessité continue d'une recherche diversifiée et inclusive sur la MP. ANN NEUROL 2024.

Translated Description (Spanish)

La enfermedad de Parkinson (EP) es un desafío de salud global, pero históricamente los estudios de EP se han realizado predominantemente en poblaciones europeas. Investigaciones genéticas recientes realizadas en poblaciones no europeas han revelado nuevos loci genéticos específicos de la población vinculados al riesgo de EP, destacando la importancia de estudiar la EP a nivel mundial. Estas ideas han ampliado nuestra comprensión de la etiología de la EP, que es crucial para desarrollar intervenciones modificadoras de la enfermedad. Esta revisión explora exhaustivamente el panorama genético global de la EP, enfatizando la justificación científica para estudiar poblaciones subrepresentadas. Subraya los desafíos, como la heterogeneidad genotipo-fenotipo y las dificultades de inclusión para los participantes no europeos, enfatizando la necesidad continua de una investigación diversa e inclusiva en la EP. ANN NEUROL 2024.

Additional details

Additional titles

Translated title (Arabic)
نحو رؤية عالمية لعلم وراثة مرض باركنسون
Translated title (French)
Vers une vision globale de la génétique de la maladie de Parkinson
Translated title (Spanish)
Hacia una visión global de la genética de la enfermedad de Parkinson

Identifiers

Other
https://openalex.org/W4393380706
DOI
10.1002/ana.26905

Is supplement to
https://openalex.org/W3216329096 (Other)
https://openalex.org/W3185553570 (Other)
https://openalex.org/W3185163327 (Other)
https://openalex.org/W3134596587 (Other)
https://openalex.org/W3116665257 (Other)
https://openalex.org/W3045247719 (Other)
https://openalex.org/W2757130632 (Other)
https://openalex.org/W2416973532 (Other)
https://openalex.org/W2155401483 (Other)
https://openalex.org/W2102102835 (Other)

GreSIS Basics Section

Is Global South Knowledge
Yes
Country
Colombia

References

  • https://openalex.org/W1499176778
  • https://openalex.org/W1558427337
  • https://openalex.org/W1838543656
  • https://openalex.org/W1941885394
  • https://openalex.org/W1963486331
  • https://openalex.org/W1977912141
  • https://openalex.org/W1978297365
  • https://openalex.org/W1981336920
  • https://openalex.org/W1983044117
  • https://openalex.org/W1986843465
  • https://openalex.org/W1997566849
  • https://openalex.org/W2003198613
  • https://openalex.org/W2004696236
  • https://openalex.org/W2010095758
  • https://openalex.org/W2010612415
  • https://openalex.org/W2021097923
  • https://openalex.org/W2021760305
  • https://openalex.org/W2024123655
  • https://openalex.org/W2026548628
  • https://openalex.org/W2027226825
  • https://openalex.org/W2039304191
  • https://openalex.org/W2039531063
  • https://openalex.org/W2056188468
  • https://openalex.org/W2058798901
  • https://openalex.org/W2059721073
  • https://openalex.org/W2063127941
  • https://openalex.org/W2063690790
  • https://openalex.org/W2068112998
  • https://openalex.org/W2080665395
  • https://openalex.org/W2091265794
  • https://openalex.org/W2092293921
  • https://openalex.org/W2093862638
  • https://openalex.org/W2095202142
  • https://openalex.org/W2096347054
  • https://openalex.org/W2097983832
  • https://openalex.org/W2100300726
  • https://openalex.org/W2109183158
  • https://openalex.org/W2115295034
  • https://openalex.org/W2123431154
  • https://openalex.org/W2130668756
  • https://openalex.org/W2133837852
  • https://openalex.org/W2134829539
  • https://openalex.org/W2135384228
  • https://openalex.org/W2136230100
  • https://openalex.org/W2137300912
  • https://openalex.org/W2143688669
  • https://openalex.org/W2145147096
  • https://openalex.org/W2150656456
  • https://openalex.org/W2151199043
  • https://openalex.org/W2154737306
  • https://openalex.org/W2160513439
  • https://openalex.org/W2165920499
  • https://openalex.org/W2170281382
  • https://openalex.org/W2171992263
  • https://openalex.org/W2208935474
  • https://openalex.org/W2598022332
  • https://openalex.org/W2602067988
  • https://openalex.org/W2617853135
  • https://openalex.org/W2619089740
  • https://openalex.org/W2631195306
  • https://openalex.org/W2754278602
  • https://openalex.org/W2754967293
  • https://openalex.org/W2783717931
  • https://openalex.org/W2797194936
  • https://openalex.org/W2894661013
  • https://openalex.org/W2898290174
  • https://openalex.org/W2904774980
  • https://openalex.org/W2904938386
  • https://openalex.org/W2913708613
  • https://openalex.org/W2946968747
  • https://openalex.org/W2972937106
  • https://openalex.org/W2977561843
  • https://openalex.org/W2986932567
  • https://openalex.org/W2989064672
  • https://openalex.org/W2998967090
  • https://openalex.org/W3000974767
  • https://openalex.org/W3001337291
  • https://openalex.org/W3010896733
  • https://openalex.org/W3017227862
  • https://openalex.org/W3029936992
  • https://openalex.org/W3036386800
  • https://openalex.org/W3048109718
  • https://openalex.org/W3080212276
  • https://openalex.org/W3105175400
  • https://openalex.org/W3110169235
  • https://openalex.org/W3113298925
  • https://openalex.org/W3125233482
  • https://openalex.org/W3152319636
  • https://openalex.org/W3188321740
  • https://openalex.org/W3196071261
  • https://openalex.org/W3201290493
  • https://openalex.org/W3208810280
  • https://openalex.org/W3211729558
  • https://openalex.org/W3217278112
  • https://openalex.org/W4200084373
  • https://openalex.org/W4220709904
  • https://openalex.org/W4220817346
  • https://openalex.org/W4224297855
  • https://openalex.org/W4225003162
  • https://openalex.org/W4226263121
  • https://openalex.org/W4280552086
  • https://openalex.org/W4281562969
  • https://openalex.org/W4283071197
  • https://openalex.org/W4285025090
  • https://openalex.org/W4286111031
  • https://openalex.org/W4286586502
  • https://openalex.org/W4289316217
  • https://openalex.org/W4317356448
  • https://openalex.org/W4319761874
  • https://openalex.org/W4365459497
  • https://openalex.org/W4365814970
  • https://openalex.org/W4376959645
  • https://openalex.org/W4380271733
  • https://openalex.org/W4386087061
  • https://openalex.org/W4386434865
  • https://openalex.org/W4387777214
  • https://openalex.org/W4388292189
  • https://openalex.org/W4388304230
  • https://openalex.org/W4388752112
  • https://openalex.org/W4389087081
  • https://openalex.org/W4389943831
  • https://openalex.org/W4390345401