Published November 10, 2017 | Version v1
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Bioactive isoquinoline alkaloids from <i>Cissampelos pareira</i>

Creators

  • 1. Academy of Scientific and Innovative Research
  • 2. Institute of Himalayan Bioresource Technology

Description

The phytochemical and biological investigation of Cissampelos pareira leads to the isolation of one new isoquinoline alkaloid (7) along with six known isoquinoline alkaloids, namely, magnoflorine (1), magnocurarine (2), cissamine (3), curine (4), hayatinine (5) and cycleanine (6). Magnoflorine (1) and magnocurarine (2) were isolated for the first time from C. pareira. A new, rapid, simple and sensitive UPLC method was developed for simultaneous quantification of five pure compounds (1-5). Seasonal variation study revealed higher content of these compounds during the rainy season. The chloroform (CPCF) and n-butanol (CPBF) fractions showed cytotoxic efficacy against KB cells. Among pure compounds, hayatinine (5) was found to be most active against KB and A549, while, cycleanine (6) against KB cells.

⚠️ This is an automatic machine translation with an accuracy of 90-95%

Translated Description (Arabic)

يؤدي الفحص الكيميائي النباتي والبيولوجي لـ Cissampelos pareira إلى عزل قلويد إيزوكينولين جديد واحد (7) إلى جانب ستة قلويدات إيزوكينولين معروفة، وهي ماغنوفلورين (1)، ماغنوكورين (2)، سيسامين (3)، كورين (4)، هاياتينين (5) وسيكلينين (6). تم عزل ماغنوفلورين (1) وماغنوكورارين (2) لأول مرة من C. parira. تم تطوير طريقة جديدة وسريعة وبسيطة وحساسة للتحديد الكمي المتزامن لخمسة مركبات نقية (1-5). كشفت دراسة التباين الموسمي عن محتوى أعلى من هذه المركبات خلال موسم الأمطار. أظهر كلوروفورم (CPCF) و n - butanol (CPBF) فعالية سامة للخلايا ضد خلايا KB. من بين المركبات النقية، وجد أن هاياتينين (5) يكون أكثر نشاطًا ضد KB و A549، بينما، سيكلينين (6) ضد خلايا KB.

Translated Description (English)

The phytochemical and biological investigation of Cissampelos pareira leads to the isolation of one new isoquinoline alkaloid (7) along with six known isoquinoline alkaloids, namely, magnoflorine (1), magnocurarine (2), cissamine (3), curine (4), hayatinine (5) and cycleanine (6). Magnoflorine (1) and magnocurarine (2) were isolated for the first time from C. pareira. A new, rapid, simple and sensitive UPLC method was developed for simultaneous quantification of five pure compounds (1-5). Seasonal variation study revealed higher content of these compounds during the rainy season. The chloroform (CPCF) and n-butanol (CPBF) fractions showed cytotoxic efficacy against KB cells. Among pure compounds, hayatinine (5) was found to be most active against KB and A549, while, cycleanine (6) against KB cells.

Translated Description (French)

L'étude phytochimique et biologique de Cissampelos pareira conduit à l'isolement d'un nouvel alcaloïde isoquinoléine (7) avec six alcaloïdes isoquinoléine connus, à savoir le magnoflorine (1), la magnocurarine (2), la cissamine (3), la curine (4), la hayatinine (5) et la cyclanine (6). Le magnoflorine (1) et la magnocurarine (2) ont été isolés pour la première fois de C. pareira. Une nouvelle méthode UPLC rapide, simple et sensible a été développée pour la quantification simultanée de cinq composés purs (1-5). L'étude des variations saisonnières a révélé une teneur plus élevée en ces composés pendant la saison des pluies. Les fractions chloroforme (CPCF) et n-butanol (CPBF) ont montré une efficacité cytotoxique contre les cellules KB. Parmi les composés purs, la hayatinine (5) s'est avérée la plus active contre KB et A549, tandis que la cyclanine (6) contre les cellules KB.

Translated Description (Spanish)

La investigación fitoquímica y biológica de Cissampelos pareira conduce al aislamiento de un nuevo alcaloide de isoquinolina (7) junto con seis alcaloides de isoquinolina conocidos, a saber, magnoflorina (1), magnocurarina (2), cissamina (3), curina (4), hayatinina (5) y ciclanina (6). Magnoflorine (1) y magnocurarine (2) se aislaron por primera vez de C. pareira. Se desarrolló un método UPLC nuevo, rápido, simple y sensible para la cuantificación simultánea de cinco compuestos puros (1-5). El estudio de variación estacional reveló un mayor contenido de estos compuestos durante la temporada de lluvias. Las fracciones de cloroformo (CPCF) y n-butanol (CPBF) mostraron eficacia citotóxica contra las células KB. Entre los compuestos puros, se encontró que la hayatinina (5) era más activa contra KB y A549, mientras que la ciclanina (6) contra las células KB.

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Additional details

Additional titles

Translated title (Arabic)
قلويدات إيزوكينولين النشطة بيولوجيًا من <i>سيسامبيلوس بارييرا</i>
Translated title (English)
Bioactive isoquinoline alkaloids from <i>Cissampelos pareira</i>
Translated title (French)
Alcaloïdes isoquinoléines bioactifs de <i>Cissampelos pareira</i>
Translated title (Spanish)
Alcaloides de isoquinolina bioactivos de <i>Cissampelos pareira</i>

Identifiers

Other
https://openalex.org/W2767511422
DOI
10.1080/14786419.2017.1402319

Is supplement to
https://openalex.org/W4310648033 (Other)
https://openalex.org/W2386186267 (Other)
https://openalex.org/W2351576280 (Other)
https://openalex.org/W2089993513 (Other)
https://openalex.org/W2068657060 (Other)
https://openalex.org/W2058822032 (Other)
https://openalex.org/W2047895708 (Other)
https://openalex.org/W2043781865 (Other)
https://openalex.org/W1977830751 (Other)
https://openalex.org/W1970030268 (Other)

GreSIS Basics Section

Is Global South Knowledge
Yes
Country
India

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