Complicated intra-abdominal infections worldwide: the definitive data of the CIAOW Study

doi:10.60692/cfpbd-gp276

Published May 14, 2014 | Version v1

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Complicated intra-abdominal infections worldwide: the definitive data of the CIAOW Study

1. University of Macerata
2. Azienda Ospedaliero Universitaria Ospedali Riuniti
3. Denver Health Medical Center
4. University of Colorado Denver
5. American Board of Internal Medicine
6. Massachusetts General Hospital
7. Harvard University
8. UC San Diego Health System
9. Kyoto University
10. Herttoniemi Hospital
11. University of Newcastle Australia
12. Government Medical College and Hospital
13. Rambam Health Care Campus
14. Fundación Valle del Lili
15. Virginia Commonwealth University
16. Universidade Estadual de Campinas (UNICAMP)
17. Clinics Hospital of Ribeirão Preto
18. Chang Gung Memorial Hospital
19. Hadassah Medical Center
20. Tianjin Nankai Hospital
21. Tianjin Medical University
22. Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences
23. Malankara Orthodox Syrian Church Medical College Hospital
24. Sher-i-Kashmir Institute of Medical Sciences
25. Kovai Medical Center and Hospital
26. Medical University Plovdiv
27. Edendale Hospital
28. Ahmadu Bello University Teaching Hospital
29. Mansoura University Hospital
30. Fundação Padre Albino
31. Hospital Clínico Universitario Virgen de la Victoria
32. Université Côte d'Azur
33. Muzeum Novojičínska
34. University Hospital Centre Zagreb
35. Mozyr State Pedagogical University named after I.P.Shamyakin
36. Ospedali Riuniti di Ancona
37. Raja Isteri Pengiran Anak Saleha Hospital
38. Limbe Provincial Hospital
39. Severance Hospital
40. Yonsei University
41. University of Ulsan
42. Siriraj Hospital
43. Thammasat University Hospital
44. Hospital Regional de Alta Especialidad del Bajío
45. Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
46. Adana Hospital
47. Hôpital d'instruction des Armées Desgenettes
48. Centre Hospitalier Universitaire Yalgado Ouédraogo
49. Tokyo Medical and Dental University
50. Matsudo City Hospital
51. Nippon Medical School
52. Our Lady of Lourdes Hospital
53. Obafemi Awolowo University
54. Chiba University Hospital
55. Toyooka Hospital
56. Jichi Medical University
57. Mayo General Hospital

The CIAOW study (Complicated intra-abdominal infections worldwide observational study) is a multicenter observational study underwent in 68 medical institutions worldwide during a six-month study period (October 2012-March 2013). The study included patients older than 18 years undergoing surgery or interventional drainage to address complicated intra-abdominal infections (IAIs). 1898 patients with a mean age of 51.6 years (range 18-99) were enrolled in the study. 777 patients (41%) were women and 1,121 (59%) were men. Among these patients, 1,645 (86.7%) were affected by community-acquired IAIs while the remaining 253 (13.3%) suffered from healthcare-associated infections. Intraperitoneal specimens were collected from 1,190 (62.7%) of the enrolled patients. 827 patients (43.6%) were affected by generalized peritonitis while 1071 (56.4%) suffered from localized peritonitis or abscesses. The overall mortality rate was 10.5% (199/1898). According to stepwise multivariate analysis (PR = 0.005 and PE = 0.001), several criteria were found to be independent variables predictive of mortality, including patient age (OR = 1.1; 95%CI = 1.0-1.1; p < 0.0001), the presence of small bowel perforation (OR = 2.8; 95%CI = 1.5-5.3; p < 0.0001), a delayed initial intervention (a delay exceeding 24 hours) (OR = 1.8; 95%CI = 1.5-3.7; p < 0.0001), ICU admission (OR = 5.9; 95%CI = 3.6-9.5; p < 0.0001) and patient immunosuppression (OR = 3.8; 95%CI = 2.1-6.7; p < 0.0001).

Translated Descriptions

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Translated Description (Arabic)

دراسة CIAOW (دراسة رصدية معقدة داخل البطن في جميع أنحاء العالم) هي دراسة رصدية متعددة المراكز أجريت في 68 مؤسسة طبية في جميع أنحاء العالم خلال فترة دراسة مدتها ستة أشهر (أكتوبر 2012 - مارس 2013). شملت الدراسة المرضى الذين تزيد أعمارهم عن 18 عامًا والذين يخضعون لعملية جراحية أو تصريف تدخلي لمعالجة الالتهابات المعقدة داخل البطن. تم تسجيل 1898 مريضًا بمتوسط عمر 51.6 عامًا (النطاق 18-99) في الدراسة. 777 مريضًا (41 ٪) من النساء و 1121 (59 ٪) من الرجال. ومن بين هؤلاء المرضى، تأثر 1645 (86.7 ٪) بالتهابات الشرايين الداخلية المكتسبة من المجتمع بينما عانى 253 (13.3 ٪) من العدوى المرتبطة بالرعاية الصحية. تم جمع عينات داخل الصفاق من 1190 (62.7 ٪) من المرضى المسجلين. تأثر 827 مريضًا (43.6 ٪) بالتهاب الصفاق المعمم بينما عانى 1071 (56.4 ٪) من التهاب الصفاق الموضعي أو الخراجات. وبلغ معدل الوفيات الإجمالي 10.5 ٪ (199/1898). وفقًا للتحليل متعدد المتغيرات التدريجي (PR = 0.005 و PE = 0.001)، تم العثور على العديد من المعايير لتكون متغيرات مستقلة تنبئ بالوفيات، بما في ذلك عمر المريض (OR = 1.1 ؛ 95 ٪CI = 1.0-1.1 ؛ p < 0.0001)، وجود ثقب في الأمعاء الدقيقة (OR = 2.8 ؛ 95 ٪CI = 1.5-5.3 ؛ p < 0.0001)، تدخل أولي متأخر (تأخير يتجاوز 24 ساعة) (OR = 1.8 ؛ 95 ٪CI = 1.5-3.7 ؛ p < 0.0001)، دخول وحدة العناية المركزة (OR = 5.9 ؛ 95 ٪CI = 3.6-9.5 ؛ p < 0.0001) وكبت مناعة المريض (OR = 3.8 ؛ 95 ٪CI = 2.1-6.7 ؛ p < 0.0001).

Translated Description (French)

L'étude CIAOW (Complicated intra-abdominal infections worldwide observational study) est une étude observationnelle multicentrique réalisée dans 68 établissements médicaux du monde entier au cours d'une période d'étude de six mois (octobre 2012-mars 2013). L'étude incluait des patients de plus de 18 ans subissant une intervention chirurgicale ou un drainage interventionnel pour traiter les infections intra-abdominales compliquées (IAI). 1898 patients d'un âge moyen de 51,6 ans (fourchette 18-99) ont été recrutés dans l'étude. 777 patients (41 %) étaient des femmes et 1 121 (59 %) étaient des hommes. Parmi ces patients, 1 645 (86,7 %) étaient touchés par des IAI acquis dans la communauté tandis que les 253 autres (13,3 %) souffraient d'infections associées aux soins de santé. Des échantillons intrapéritonéaux ont été prélevés chez 1 190 (62,7 %) des patients inclus. 827 patients (43,6 %) étaient atteints de péritonite généralisée tandis que 1 071 (56,4 %) souffraient de péritonite localisée ou d'abcès. Le taux de mortalité global était de 10,5 % (199/1898). Selon une analyse multivariée par étapes (PR = 0,005 et EP = 0,001), plusieurs critères se sont avérés être des variables indépendantes prédictives de la mortalité, notamment l'âge du patient (OR = 1,1 ; IC à 95 % = 1,0-1,1 ; p < 0,0001), la présence d'une perforation de l'intestin grêle (OR = 2,8 ; IC à 95 % = 1,5-5,3 ; p < 0,0001), une intervention initiale retardée (un retard dépassant 24 heures) (OR = 1,8 ; IC à 95 % = 1,5-3,7 ; p < 0,0001), l'admission en USI (OR = 5,9 ; IC à 95 % = 3,6-9,5 ; p < 0,0001) et l'immunosuppression du patient (OR = 3,8 ; IC à 95 % = 2,1-6,7 ; p < 0,0001).

Translated Description (Spanish)

El estudio CIAOW (Complicated intra-abdominal infections worldwide observational study) es un estudio multicéntrico realizado en 68 instituciones médicas de todo el mundo durante un período de estudio de seis meses (octubre de 2012-marzo de 2013). El estudio incluyó pacientes mayores de 18 años sometidos a cirugía o drenaje intervencionista para tratar infecciones intraabdominales complicadas (IAI). Se inscribieron en el estudio 1.898 pacientes con una edad media de 51,6 años (rango 18-99). 777 pacientes (41%) eran mujeres y 1.121 (59%) eran hombres. Entre estos pacientes, 1.645 (86,7%) se vieron afectados por IAI adquiridos en la comunidad, mientras que los 253 restantes (13,3%) sufrieron infecciones asociadas a la atención médica. Se recolectaron muestras intraperitoneales de 1,190 (62.7%) de los pacientes inscritos. 827 pacientes (43.6%) se vieron afectados por peritonitis generalizada, mientras que 1071 (56.4%) sufrieron peritonitis o abscesos localizados. La tasa de mortalidad general fue del 10,5% (199/1898). De acuerdo con el análisis multivariante escalonado (PR = 0,005 y PE = 0,001), se encontraron varios criterios como variables independientes predictivas de mortalidad, incluyendo la edad del paciente (OR = 1,1; IC 95% = 1,0-1,1; p < 0,0001), la presencia de perforación del intestino delgado (OR = 2,8; IC 95% = 1,5-5,3; p < 0,0001), una intervención inicial retrasada (un retraso superior a 24 horas) (OR = 1,8; IC 95% = 1,5-3,7; p < 0,0001), ingreso en UCI (OR = 5,9; IC 95% = 3,6-9,5; p < 0,0001) e inmunosupresión del paciente (OR = 3,8; IC 95% = 2,1-6,7; p < 0,0001).

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Translated title (Arabic): الالتهابات المعقدة داخل البطن في جميع أنحاء العالم: البيانات النهائية لدراسة CIAOW
Translated title (French): Infections intra-abdominales compliquées dans le monde : les données définitives de l'étude CIAOW
Translated title (Spanish): Infecciones intraabdominales complicadas en todo el mundo: los datos definitivos del estudio CIAOW

Other: https://openalex.org/W2108565421
DOI: 10.1186/1749-7922-9-37

Is Global South Knowledge: Yes
Country: Colombia

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Complicated intra-abdominal infections worldwide: the definitive data of the CIAOW Study

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Translated Description (Arabic)

Translated Description (French)

Translated Description (Spanish)

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Complicated intra-abdominal infections worldwide: the definitive data of the CIAOW Study

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Translated Descriptions

Translated Description (Arabic)

Translated Description (French)

Translated Description (Spanish)

Files

1749-7922-9-37.pdf

Files (768.0 kB)

Additional details

Additional titles

Identifiers

Related works

GreSIS Basics Section

References