Published June 11, 2024 | Version v1
Publication Open

Gestational intermittent hypoxia reduces mandibular growth with decreased Sox9 expression and increased Hif1a expression in male offspring rats

Creators

  • 1. Tokyo Medical and Dental University
  • 2. The University of Tokyo
  • 3. Tokyo Medical University
  • 4. Osaka University
  • 5. Chulalongkorn University

Description

Maternal obstructive sleep apnea (OSA) during pregnancy is the risk factor for impaired fetal growth with low birth weight in the offspring. However, it is unclear whether gestational intermittent hypoxia (IH, a hallmark of maternal OSA) has long-term detrimental consequences on the skeletal development of offspring. This study aimed to investigate postnatal maxillofacial bone growth and cartilage metabolism in male and female offspring that were exposed to gestational IH.

⚠️ This is an automatic machine translation with an accuracy of 90-95%

Translated Description (Arabic)

انقطاع النفس الانسدادي أثناء النوم (OSA) أثناء الحمل هو عامل الخطر لنمو الجنين الضعيف مع انخفاض الوزن عند الولادة في النسل. ومع ذلك، ليس من الواضح ما إذا كان نقص الأكسجة المتقطع الحملي (IH، السمة المميزة لـ OSA للأم) له عواقب ضارة طويلة الأجل على نمو الهيكل العظمي للذرية. تهدف هذه الدراسة إلى التحقيق في نمو عظام الفكين والوجه بعد الولادة واستقلاب الغضروف في ذرية الذكور والإناث التي تعرضت لـ IH الحملي.

Translated Description (French)

L'apnée obstructive du sommeil (AOS) maternelle pendant la grossesse est le facteur de risque d'altération de la croissance fœtale avec un faible poids à la naissance chez la progéniture. Cependant, il n'est pas clair si l'hypoxie intermittente gestationnelle (IH, une caractéristique de l'AOS maternelle) a des conséquences néfastes à long terme sur le développement squelettique de la progéniture. Cette étude visait à étudier la croissance osseuse maxillo-faciale postnatale et le métabolisme du cartilage chez les descendants mâles et femelles exposés à l'HI gestationnel.

Translated Description (Spanish)

La apnea obstructiva del sueño (aos) materna durante el embarazo es el factor de riesgo de deterioro del crecimiento fetal con bajo peso al nacer en la descendencia. Sin embargo, no está claro si la hipoxia intermitente gestacional (IH, un sello distintivo de la aos materna) tiene consecuencias perjudiciales a largo plazo en el desarrollo esquelético de la descendencia. Este estudio tuvo como objetivo investigar el crecimiento óseo maxilofacial posnatal y el metabolismo del cartílago en descendientes masculinos y femeninos que estuvieron expuestos a HI gestacional.

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Additional details

Additional titles

Translated title (Arabic)
يقلل نقص الأكسجة المتقطع الحملي من نمو الفك السفلي مع انخفاض تعبير Sox9 وزيادة تعبير Hif1a في ذكور الفئران
Translated title (French)
L'hypoxie intermittente gestationnelle réduit la croissance mandibulaire avec une diminution de l'expression de SOx9 et une augmentation de l'expression de Hif1a chez les rats mâles
Translated title (Spanish)
La hipoxia intermitente gestacional reduce el crecimiento mandibular con una disminución de la expresión de Sox9 y un aumento de la expresión de Hif1a en ratas macho

Identifiers

Other
https://openalex.org/W4399572374
DOI
10.3389/fphys.2024.1397262

Is supplement to
https://openalex.org/W4388832197 (Other)
https://openalex.org/W4231313959 (Other)
https://openalex.org/W3039082282 (Other)
https://openalex.org/W3030806300 (Other)
https://openalex.org/W2899681357 (Other)
https://openalex.org/W2496469184 (Other)
https://openalex.org/W2105558110 (Other)
https://openalex.org/W2016258313 (Other)
https://openalex.org/W2008430621 (Other)
https://openalex.org/W1996322489 (Other)

GreSIS Basics Section

Is Global South Knowledge
Yes
Country
Thailand

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