Published February 17, 2019 | Version v1
Publication Open

Sesquiterpenes rich essential oil from <i>Garcinia celebica</i> L. and its cytotoxic and antimicrobial activities

Creators

  • 1. Universiti Sains Malaysia
  • 2. University of Kuala Lumpur
  • 3. Universiti Teknologi Petronas

Description

Garcinia celebica L., locally known as "manggis hutan" in Malaysia is widely used in folkloric medicine to treat various diseases. The present study was aimed to examine the chemical composition of the essential oil from the leaves of G. celebica L. (EO-GC) and its cytotoxic and antimicrobial potential. EO-GC obtained by hydrodistillation was analysed using capillary GC and GC-MS. Twenty-two compounds were identified, dominated by α-copaene (61.25%), germacrene D (6.72%) and β-caryophyllene (5.85%). In the in vitro MTT assay, EO-GC exhibited significant anti-proliferative effects towards MCF-7 human breast cancer cells with IC50 value of 45.2 μg/mL. Regarding the antimicrobial activity, it showed better inhibitory effects on Gram-positive bacteria than Gram-negative bacteria and none on the fungi and yeasts tested.

⚠️ This is an automatic machine translation with an accuracy of 90-95%

Translated Description (Arabic)

يستخدم Garcinia celebica L.، المعروف محليًا باسم "manggis hutan" في ماليزيا على نطاق واسع في الطب الفولكلوري لعلاج الأمراض المختلفة. هدفت الدراسة الحالية إلى فحص التركيب الكيميائي للزيت العطري من أوراق G. celebica L. (EO - GC) وإمكاناته السامة للخلايا والمضادة للميكروبات. تم تحليل EO - GC التي تم الحصول عليها عن طريق التقطير المائي باستخدام GC الشعري و GC - MS. تم تحديد اثنين وعشرين مركبًا، يهيمن عليها α - copaene (61.25 ٪)، و germacrene D (6.72 ٪) و β - caryophyllene (5.85 ٪). في اختبار MTT في المختبر، أظهر EO - GC تأثيرات كبيرة مضادة للتكاثر تجاه خلايا سرطان الثدي البشرية MCF -7 بقيمة IC50 تبلغ 45.2 ميكروغرام/مل. فيما يتعلق بالنشاط المضاد للميكروبات، أظهر تأثيرات مثبطة أفضل على البكتيريا إيجابية الجرام من البكتيريا سالبة الجرام ولا شيء على الفطريات والخمائر التي تم اختبارها.

Translated Description (English)

Garcinia celebica L., locally known as "manggis hutan" in Malaysia is widely used in folkloric medicine to treat various diseases. The present study was aimed at examining the chemical composition of the essential oil from the leaves of G. celebica L. (EO-GC) and its cytotoxic and antimicrobial potential. EO-GC obtained by hydrodistillation was analysed using capillary GC and GC-MS. Twenty-two compounds were identified, dominated by α-copaene (61.25%), germacrene D (6.72%) and β-caryophyllene (5.85%). In the in vitro MTT assay, EO-GC exhibited significant anti-proliferative effects towards MCF-7 human breast cancer cells with an IC50 value of 45.2 μg/mL. Regarding the antimicrobial activity, it showed better inhibitory effects on Gram-positive bacteria than Gram-negative bacteria and none on the fungi and yeasts tested.

Translated Description (French)

Garcinia celebica L., localement connu sous le nom de « manggis hutan » en Malaisie, est largement utilisé en médecine folklorique pour traiter diverses maladies. La présente étude visait à examiner la composition chimique de l'huile essentielle des feuilles de G. celebica L. (EO-GC) et son potentiel cytotoxique et antimicrobien. L'EO-GC obtenu par hydrodistillation a été analysé par CPG capillaire et CPG-MS. Vingt-deux composés ont été identifiés, dominés par l'α-copaène (61,25 %), le germacrène D (6,72 %) et le β-caryophyllène (5,85 %). Dans le test MTT in vitro, l'EO-GC a montré des effets anti-prolifératifs significatifs sur les cellules cancéreuses du sein humain MCF-7 avec une valeur IC50 de 45,2 μg/mL. En ce qui concerne l'activité antimicrobienne, elle a montré de meilleurs effets inhibiteurs sur les bactéries à Gram positif que les bactéries à Gram négatif et aucun sur les champignons et levures testés.

Translated Description (Spanish)

Garcinia celebica L., conocida localmente como "manggis hutan" en Malasia, es ampliamente utilizada en la medicina folclórica para tratar diversas enfermedades. El presente estudio tuvo como objetivo examinar la composición química del aceite esencial de las hojas de G. celebica L. (EO-GC) y su potencial citotóxico y antimicrobiano. El EO-GC obtenido por hidrodestilación se analizó utilizando GC capilar y GC-MS. Se identificaron veintidós compuestos, dominados por α-copaeno (61,25%), germacreno D (6,72%) y β-cariofileno (5,85%). En el ensayo MTT in vitro, EO-GC exhibió efectos antiproliferativos significativos hacia las células de cáncer de mama humano MCF-7 con un valor de IC50 de 45.2 μg/mL. Con respecto a la actividad antimicrobiana, mostró mejores efectos inhibidores sobre las bacterias Gram-positivas que las bacterias Gram-negativas y ninguno sobre los hongos y levaduras probados.

Files

14387795.pdf.pdf

Files (413.9 kB)

⚠️ Please wait a few minutes before your translated files are ready ⚠️ Note: Some files might be protected thus translations might not work.
Name Size Download all
md5:309d983d08d7dcccd40921453bbde0e4
413.9 kB
Preview Download

Additional details

Additional titles

Translated title (Arabic)
Sesquiterpenes زيت عطري غني من <i>Garcinia celebica</i> L. وأنشطته السامة للخلايا والمضادة للميكروبات
Translated title (English)
Sesquiterpenes rich essential oil from <i>Garcinia celebica</i> L. and its cytotoxic and antimicrobial activities
Translated title (French)
Huile essentielle riche en sesquiterpènes de <i>Garcinia celebica</i> L. et ses activités cytotoxiques et antimicrobiennes
Translated title (Spanish)
Aceite esencial rico en sesquiterpenos de <i>Garcinia celebica</i> L. y sus actividades citotóxicas y antimicrobianas

Identifiers

Other
https://openalex.org/W2914853809
DOI
10.1080/14786419.2019.1569012

Is supplement to
https://openalex.org/W4387982961 (Other)
https://openalex.org/W2922378416 (Other)
https://openalex.org/W2885323518 (Other)
https://openalex.org/W2586245348 (Other)
https://openalex.org/W2380741856 (Other)
https://openalex.org/W2363807410 (Other)
https://openalex.org/W2358368915 (Other)
https://openalex.org/W2158507284 (Other)
https://openalex.org/W2035337314 (Other)
https://openalex.org/W1990348080 (Other)

GreSIS Basics Section

Is Global South Knowledge
Yes
Country
Malaysia

References

  • https://openalex.org/W1753271690
  • https://openalex.org/W1966480046
  • https://openalex.org/W2011444187
  • https://openalex.org/W2077670474
  • https://openalex.org/W2109365702
  • https://openalex.org/W2113010874
  • https://openalex.org/W2126891371
  • https://openalex.org/W2138762289
  • https://openalex.org/W2164168857
  • https://openalex.org/W2175374775
  • https://openalex.org/W2281263441
  • https://openalex.org/W2323196950
  • https://openalex.org/W2562282801
  • https://openalex.org/W2744706787
  • https://openalex.org/W2884930393
  • https://openalex.org/W3202111423