Published January 1, 2013
| Version v1
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Maturation and Emigration of Single-Positive Thymocytes
- 1. Peking University
- 2. Peking University People's Hospital
- 3. Kunming Medical University
Description
T lymphopoiesis in the thymus was thought to be completed once it reaches the single positive (SP) stage, a stage when T cells are "fully mature" and waiting to be exported at random or follow a "first-in-first-out" manner. Recent evidence, however, has revealed that the newly generated SP thymocytes undergo a multistage maturation program in the thymic medulla. Such maturation is followed by a tightly regulated emigration process and a further postthymic maturation of recent thymic emigrants (RTEs). This review summarizes recent progress in the late stage T cell development. The regulation of this developmental process is discussed.
Translated Descriptions
⚠️
This is an automatic machine translation with an accuracy of 90-95%
Translated Description (Arabic)
كان يُعتقد أن تكوين اللمفاويات التائية في الغدة الصعترية يكتمل بمجرد وصوله إلى مرحلة إيجابية واحدة، وهي مرحلة تكون فيها الخلايا التائية "ناضجة تمامًا" وتنتظر تصديرها بشكل عشوائي أو اتباع طريقة "الوارد أولاً يخرج أولاً". ومع ذلك، كشفت الأدلة الحديثة أن الخلايا الصعترية SP المولدة حديثًا تخضع لبرنامج نضج متعدد المراحل في النخاع الصعتري. يتبع هذا النضج عملية هجرة منظمة بإحكام ونضج آخر بعد التوتة للمهاجرين التوتة الجدد (RTEs). تلخص هذه المراجعة التقدم الأخير في تطور الخلايا التائية في المرحلة المتأخرة. تتم مناقشة تنظيم هذه العملية التنموية.Translated Description (French)
On pensait que la lymphopoïèse T dans le thymus était terminée une fois qu'elle atteignait le stade positif unique (SP), un stade où les cellules T sont « complètement matures » et attendent d'être exportées au hasard ou de suivre une méthode « premier entré, premier sorti ». Des preuves récentes, cependant, ont révélé que les thymocytes SP nouvellement générés subissent un programme de maturation en plusieurs étapes dans la moelle thymique. Cette maturation est suivie d'un processus d'émigration étroitement réglementé et d'une nouvelle maturation postthymique des émigrants thymiques récents (ETR). Cette revue résume les progrès récents dans le développement tardif des lymphocytes T. La régulation de ce processus de développement est discutée.Translated Description (Spanish)
Se pensaba que la linfopoyesis T en el timo se completaba una vez que alcanzaba la etapa positiva única (SP), una etapa en la que las células T están "completamente maduras" y esperando ser exportadas al azar o seguir una manera de "primero en entrar, primero en salir". Sin embargo, la evidencia reciente ha revelado que los timocitos SP recién generados se someten a un programa de maduración de múltiples etapas en la médula tímica. Dicha maduración es seguida por un proceso de emigración estrictamente regulado y una maduración posttímica adicional de los emigrantes tímicos recientes (RTE). Esta revisión resume el progreso reciente en el desarrollo tardío de las células T. Se discute la regulación de este proceso de desarrollo.Files
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Additional details
Additional titles
- Translated title (Arabic)
- نضج وهجرة الخلايا الصعترية أحادية الموجب
- Translated title (French)
- Maturation et émigration des thymocytes positifs uniques
- Translated title (Spanish)
- Maduración y emigración de timocitos positivos únicos
Identifiers
- Other
- https://openalex.org/W2103169462
- DOI
- 10.1155/2013/282870
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