Published December 27, 2017
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New 2-arylbenzofurans from the root bark of <i>Artocarpus gomezianus</i> and their α-glucosidase inhibitory activity
Creators
- 1. Chulalongkorn University
Description
Two new 2-arylbenzofurans, namely 13-O-methyllakoochin B (1) and artogomezianin (2), were isolated from the root bark of Artocarpus gomezianus, along with six known compounds (3–8). The structures of new compounds were determined by spectroscopic and chemical methods. All of the isolates were evaluated for their α-glucosidase inhibitory activity. Artogomezianin (2) and lakoochin A (3) exhibited strong α-glucosidase inhibitory activity with IC50 values of 18.25 and 26.19 µM, respectively, as compared with the positive control acarbose.
Translated Descriptions
⚠️
This is an automatic machine translation with an accuracy of 90-95%
Translated Description (Arabic)
تم عزل اثنين جديدين من الأريل بنزوفوران، وهما 13 - O - methyllakoochin B (1) و artogomezianin (2)، من لحاء جذر Artocarpus gomezianus، إلى جانب ستة مركبات معروفة (3–8). تم تحديد هياكل المركبات الجديدة بالطرق الطيفية والكيميائية. تم تقييم جميع العزلات لنشاطها المثبط لـ α - glucosidase. أظهر Artogomezianin (2) و lakoochin A (3) نشاطًا مثبطًا قويًا لـ α - glucosidase بقيم IC50 تبلغ 18.25 و 26.19 ميكرومتر، على التوالي، مقارنةً بأكربوز التحكم الإيجابي.Translated Description (French)
Deux nouveaux 2-arylbenzofuranes, à savoir la 13-O-méthyllakoochine B (1) et l'artogomézianine (2), ont été isolés de l'écorce racinaire d'Artocarpus gomezianus, ainsi que six composés connus (3–8). Les structures des nouveaux composés ont été déterminées par des méthodes spectroscopiques et chimiques. Tous les isolats ont été évalués pour leur activité inhibitrice de l'α-glucosidase. L'artogomézianine (2) et la lakoochine A (3) ont montré une forte activité inhibitrice de l'α-glucosidase avec des valeurs de CI50 de 18,25 et 26,19 µM, respectivement, par rapport à l'acarbose témoin positif.Translated Description (Spanish)
Se aislaron dos nuevos 2-arilbenzofuranos, a saber, 13-O-metillakoochin B (1) y artogomezianina (2), de la corteza de la raíz de Artocarpus gomezianus, junto con seis compuestos conocidos (3–8). Las estructuras de los nuevos compuestos se determinaron mediante métodos espectroscópicos y químicos. Todos los aislados se evaluaron para determinar su actividad inhibidora de α-glucosidasa. La artogomezianina (2) y la lacoquina A (3) mostraron una fuerte actividad inhibidora de la α-glucosidasa con valores de IC50 de 18,25 y 26,19 µM, respectivamente, en comparación con la acarbosa de control positivo.Files
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Additional details
Additional titles
- Translated title (Arabic)
- 2 -أريل بنزوفيوران جديد من لحاء جذر <i>أرتوكاربوس غوميزيانوس</i> ونشاطه المثبط α - glucosidase
- Translated title (French)
- Nouveaux 2-arylbenzofuranes de l'écorce racinaire d'<i>Artocarpus gomezianus et</i> leur activité inhibitrice de l'α-glucosidase
- Translated title (Spanish)
- Nuevos 2-arilbenzofuranos de la corteza de la raíz de <i>Artocarpus gomezianus</i> y su actividad inhibidora de la α-glucosidasa
Identifiers
- Other
- https://openalex.org/W2780237675
- DOI
- 10.1080/14786419.2017.1419238
References
- https://openalex.org/W1982925116
- https://openalex.org/W2045011228
- https://openalex.org/W2045183537
- https://openalex.org/W2051964203
- https://openalex.org/W2056123704
- https://openalex.org/W2066517040
- https://openalex.org/W2083625598
- https://openalex.org/W2087343704
- https://openalex.org/W2090215083
- https://openalex.org/W2516724979
- https://openalex.org/W2748552877
- https://openalex.org/W4246131648
- https://openalex.org/W4253739076
- https://openalex.org/W618376376