Published May 18, 2022 | Version v1
Publication Open

Exploring the multifactorial aspects of Gut Microbiome in Parkinson's Disease

Creators

  • 1. Manipal Academy of Higher Education
  • 2. Kasturba Medical College, Manipal
  • 3. Bharati Vidyapeeth Deemed University
  • 4. Translational Health Science and Technology Institute
  • 5. University of Cambridge
  • 6. National Institute of Cholera and Enteric Diseases

Description

Advanced research in health science has broadened our view in approaching and understanding the pathophysiology of diseases and has also revolutionised diagnosis and treatment. Ever since the establishment of Braak's hypothesis in the propagation of alpha-synuclein from the distant olfactory and enteric nervous system towards the brain in Parkinson's Disease (PD), studies have explored and revealed the involvement of altered gut microbiota in PD. This review recapitulates the gut microbiome associated with PD severity, duration, motor and non-motor symptoms, and antiparkinsonian treatment from recent literature. Gut microbial signatures in PD are potential predictors of the disease and are speculated to be used in early diagnosis and treatment. In brief, the review also emphasises on implications of the prebiotic, probiotic, faecal microbiota transplantation, and dietary interventions as alternative treatments in modulating the disease symptoms in PD.

⚠️ This is an automatic machine translation with an accuracy of 90-95%

Translated Description (Arabic)

لقد وسعت الأبحاث المتقدمة في العلوم الصحية نظرتنا في التعامل مع الفيزيولوجيا المرضية للأمراض وفهمها، كما أحدثت ثورة في التشخيص والعلاج. منذ إنشاء فرضية براك في انتشار ألفا سينوكلين من الجهاز الشمي والعصبي المعوي البعيد نحو الدماغ في مرض باركنسون (PD)، استكشفت الدراسات وكشفت عن تورط ميكروبات الأمعاء المتغيرة في مرض باركنسون. تلخص هذه المراجعة ميكروبيوم الأمعاء المرتبط بشدة مرض باركنسون ومدته وأعراضه الحركية وغير الحركية والعلاج المضاد للباركنسون من الأدبيات الحديثة. التوقيعات الميكروبية المعوية في مرض باركنسون هي مؤشرات محتملة للمرض ومن المتوقع استخدامها في التشخيص والعلاج المبكرين. باختصار، تؤكد المراجعة أيضًا على الآثار المترتبة على زرع الكائنات الحية الدقيقة قبل الحيوية والبروبيوتيك والبراز والتدخلات الغذائية كعلاجات بديلة في تعديل أعراض المرض في مرض باركنسون.

Translated Description (French)

La recherche avancée en sciences de la santé a élargi notre vision de l'approche et de la compréhension de la physiopathologie des maladies et a également révolutionné le diagnostic et le traitement. Depuis l'établissement de l'hypothèse de Braak sur la propagation de l'alpha-synucléine du système nerveux olfactif et entérique distant vers le cerveau dans la maladie de Parkinson (MP), des études ont exploré et révélé l'implication du microbiote intestinal altéré dans la MP. Cette revue récapitule le microbiome intestinal associé à la gravité, à la durée, aux symptômes moteurs et non moteurs de la MP et au traitement antiparkinsonien de la littérature récente. Les signatures microbiennes intestinales dans la MP sont des prédicteurs potentiels de la maladie et sont supposées être utilisées dans le diagnostic et le traitement précoces. En bref, la revue met également l'accent sur les implications de la transplantation prébiotique, probiotique, du microbiote fécal et des interventions diététiques en tant que traitements alternatifs pour moduler les symptômes de la maladie de Parkinson.

Translated Description (Spanish)

La investigación avanzada en ciencias de la salud ha ampliado nuestra visión para abordar y comprender la fisiopatología de las enfermedades y también ha revolucionado el diagnóstico y el tratamiento. Desde el establecimiento de la hipótesis de Braak en la propagación de la alfa-sinucleína desde el sistema nervioso olfativo y entérico distante hacia el cerebro en la enfermedad de Parkinson (EP), los estudios han explorado y revelado la participación de la microbiota intestinal alterada en la EP. Esta revisión recapitula el microbioma intestinal asociado con la gravedad de la EP, la duración, los síntomas motores y no motores y el tratamiento antiparkinsoniano de la literatura reciente. Las firmas microbianas intestinales en la EP son posibles predictores de la enfermedad y se especula que se utilizarán en el diagnóstico y tratamiento tempranos. En resumen, la revisión también enfatiza las implicaciones del trasplante prebiótico, probiótico, de microbiota fecal y las intervenciones dietéticas como tratamientos alternativos para modular los síntomas de la enfermedad en la EP.

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Additional details

Additional titles

Translated title (Arabic)
استكشاف الجوانب متعددة العوامل لميكروبيوم الأمعاء في مرض باركنسون
Translated title (French)
Explorer les aspects multifactoriels du microbiome intestinal dans la maladie de Parkinson
Translated title (Spanish)
Explorando los aspectos multifactoriales del microbioma intestinal en la enfermedad de Parkinson

Identifiers

Other
https://openalex.org/W4280528089
DOI
10.1007/s12223-022-00977-2

Is supplement to
https://openalex.org/W4385758677 (Other)
https://openalex.org/W4294609011 (Other)
https://openalex.org/W4293875106 (Other)
https://openalex.org/W3177326661 (Other)
https://openalex.org/W3149981945 (Other)
https://openalex.org/W2990085632 (Other)
https://openalex.org/W2887172577 (Other)
https://openalex.org/W2755483873 (Other)
https://openalex.org/W2586739247 (Other)
https://openalex.org/W2407656459 (Other)

GreSIS Basics Section

Is Global South Knowledge
Yes
Country
India

References

  • https://openalex.org/W145539028
  • https://openalex.org/W1515023627
  • https://openalex.org/W1574681462
  • https://openalex.org/W1663623302
  • https://openalex.org/W1779994739
  • https://openalex.org/W1869241081
  • https://openalex.org/W1897759802
  • https://openalex.org/W1903888485
  • https://openalex.org/W1934236512
  • https://openalex.org/W1966873151
  • https://openalex.org/W1967659552
  • https://openalex.org/W1968105193
  • https://openalex.org/W1979237351
  • https://openalex.org/W1985597770
  • https://openalex.org/W1992780204
  • https://openalex.org/W199354732
  • https://openalex.org/W1995281235
  • https://openalex.org/W1999702935
  • https://openalex.org/W2007666404
  • https://openalex.org/W2011719513
  • https://openalex.org/W2019946207
  • https://openalex.org/W2022322161
  • https://openalex.org/W2022499239
  • https://openalex.org/W2027350208
  • https://openalex.org/W2033185924
  • https://openalex.org/W2033386838
  • https://openalex.org/W2047701363
  • https://openalex.org/W2050865611
  • https://openalex.org/W2063686053
  • https://openalex.org/W2064344027
  • https://openalex.org/W2073953969
  • https://openalex.org/W2085022353
  • https://openalex.org/W2087482196
  • https://openalex.org/W2090925778
  • https://openalex.org/W2097335121
  • https://openalex.org/W2109113634
  • https://openalex.org/W2112940088
  • https://openalex.org/W2117503265
  • https://openalex.org/W2128486395
  • https://openalex.org/W2135661538
  • https://openalex.org/W2146180881
  • https://openalex.org/W2166562121
  • https://openalex.org/W2168353938
  • https://openalex.org/W2171351284
  • https://openalex.org/W2214388745
  • https://openalex.org/W2233291722
  • https://openalex.org/W2267861477
  • https://openalex.org/W2295084775
  • https://openalex.org/W2501275879
  • https://openalex.org/W2508023300
  • https://openalex.org/W2509213166
  • https://openalex.org/W2523444109
  • https://openalex.org/W2528438579
  • https://openalex.org/W2550869378
  • https://openalex.org/W2585409334
  • https://openalex.org/W2587959748
  • https://openalex.org/W2616539606
  • https://openalex.org/W2657790599
  • https://openalex.org/W2681281215
  • https://openalex.org/W2746835184
  • https://openalex.org/W2755336277
  • https://openalex.org/W2789728109
  • https://openalex.org/W2790781105
  • https://openalex.org/W2791858901
  • https://openalex.org/W2801009528
  • https://openalex.org/W2801763052
  • https://openalex.org/W2806735213
  • https://openalex.org/W2889234747
  • https://openalex.org/W2892510782
  • https://openalex.org/W2892711299
  • https://openalex.org/W2896624029
  • https://openalex.org/W2906418973
  • https://openalex.org/W2908548900
  • https://openalex.org/W2911442568
  • https://openalex.org/W2948953869
  • https://openalex.org/W2951344089
  • https://openalex.org/W2951517287
  • https://openalex.org/W2952437732
  • https://openalex.org/W2952564192
  • https://openalex.org/W2953625730
  • https://openalex.org/W2955669984
  • https://openalex.org/W2961254431
  • https://openalex.org/W2964896323
  • https://openalex.org/W2968035162
  • https://openalex.org/W2971978790
  • https://openalex.org/W2976124415
  • https://openalex.org/W2990100110
  • https://openalex.org/W2991344020
  • https://openalex.org/W2995752611
  • https://openalex.org/W3005198362
  • https://openalex.org/W3007584245
  • https://openalex.org/W3021053184
  • https://openalex.org/W3033892147
  • https://openalex.org/W3035602929
  • https://openalex.org/W3036274992
  • https://openalex.org/W3036895273
  • https://openalex.org/W3080441033
  • https://openalex.org/W3081450923
  • https://openalex.org/W3084082471
  • https://openalex.org/W3089037850
  • https://openalex.org/W3089396568
  • https://openalex.org/W3092261610
  • https://openalex.org/W3093144984
  • https://openalex.org/W3103867983
  • https://openalex.org/W3114428384
  • https://openalex.org/W3120753707
  • https://openalex.org/W3134209205
  • https://openalex.org/W3134883668
  • https://openalex.org/W3135171367
  • https://openalex.org/W3157230943
  • https://openalex.org/W3170522065
  • https://openalex.org/W3194972182
  • https://openalex.org/W3197782746
  • https://openalex.org/W3214815292