Published May 13, 2020 | Version v1
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A new secoiridoid glycoside and other constituents from the roots and flowers of <i>Fagraea fragrans</i> Roxb. (Gentianaceae)

Creators

  • 1. Khon Kaen University
  • 2. University of Wollongong

Description

A new secoiridoid glycoside, 3'-O-p-trans-coumaroylsweroside (1), together with twenty-nine compounds (2-30), were isolated from the roots and flowers of Fagraea fragrans Roxb. (Gentianaceae). Their structures were identified by analysis of mass spectrometric and NMR spectroscopic data. Compounds 2, 4, 6, 11 and 13-15 showed weak to moderate cytotoxicity against cholangiocarcinoma cancer cells lines (KKU-213, KKU-055 and KKU-214). We report the first phytochemical investigation of the roots and flowers of F. fragrans, as only the essential oil of the latter has been investigated.

⚠️ This is an automatic machine translation with an accuracy of 90-95%

Translated Description (Arabic)

تم عزل جليكوسيد secoiridoid جديد، 3'- O - p - trans - coumaroylsweroside (1)، جنبًا إلى جنب مع تسعة وعشرين مركبًا (2-30)، من جذور وزهور Fagraea fragrans Roxb. (Gentianaceae). تم تحديد هياكلها من خلال تحليل بيانات مطيافية الكتلة وبيانات مطيافية الرنين المغناطيسي النووي. أظهرت المركبات 2 و 4 و 6 و 11 و 13-15 سمية خلوية ضعيفة إلى معتدلة ضد خطوط خلايا سرطان الأوعية الصفراوية (KKU -213 و KKU -055 و KKU -214). نبلغ عن أول تحقيق كيميائي نباتي لجذور وزهور F. Fragrans، حيث تم التحقيق فقط في الزيت العطري لهذا الأخير.

Translated Description (French)

Un nouveau glycoside sécoiridoïde, le 3'-O-p-trans-coumaroylsweroside (1), ainsi que vingt-neuf composés (2-30), ont été isolés à partir des racines et des fleurs de Fagraea fragrans Roxb. (Gentianaceae). Leurs structures ont été identifiées par analyse de données de spectrométrie de masse et de spectroscopie RMN. Les composés 2, 4, 6, 11 et 13-15 ont montré une cytotoxicité faible à modérée contre les lignées de cellules cancéreuses du cholangiocarcinome (KKU-213, KKU-055 et KKU-214). Nous rapportons la première enquête phytochimique sur les racines et les fleurs de F. fragrans, car seule l'huile essentielle de cette dernière a été étudiée.

Translated Description (Spanish)

Se aisló un nuevo glucósido secoiridoide, 3'-O-p-trans-cumaroilsweroside (1), junto con veintinueve compuestos (2-30), de las raíces y flores de Fagraea fragrans Roxb. (Gentianaceae), sus estructuras fueron identificadas mediante análisis de datos de espectrometría de masas y espectroscopía de RMN. Los compuestos 2, 4, 6, 11 y 13-15 mostraron citotoxicidad débil a moderada contra las líneas celulares de cáncer de colangiocarcinoma (KKU-213, KKU-055 y KKU-214). Presentamos la primera investigación fitoquímica de las raíces y flores de F. fragrans, ya que solo se ha investigado el aceite esencial de este último.

Files

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Additional details

Additional titles

Translated title (Arabic)
جليكوسيد سيكويريدويد جديد ومكونات أخرى من جذور وزهور فاجرايا <i>فراغرانس روكسب</i>. (الجنطيات)
Translated title (French)
Un nouveau glycoside sécoiridoïde et d'autres constituants des racines et des fleurs de <i>Fagraea fragrans</i> Roxb. (Gentianaceae)
Translated title (Spanish)
Un nuevo glucósido secoiridoide y otros constituyentes de las raíces y flores de <i>Fagraea fragrans</i> Roxb. (Gentianaceae)

Identifiers

Other
https://openalex.org/W3025973358
DOI
10.1080/14786419.2020.1749611

Is supplement to
https://openalex.org/W3025973358 (Other)
https://openalex.org/W2896974279 (Other)
https://openalex.org/W2376605885 (Other)
https://openalex.org/W2362900869 (Other)
https://openalex.org/W2362416704 (Other)
https://openalex.org/W2329038441 (Other)
https://openalex.org/W2087231392 (Other)
https://openalex.org/W2073127169 (Other)
https://openalex.org/W2073027069 (Other)
https://openalex.org/W1991962521 (Other)

GreSIS Basics Section

Is Global South Knowledge
Yes
Country
Thailand

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