Published May 9, 2012 | Version v1
Publication Open

Is Chronic Lymphocytic Leukemia a Mistake of Tolerance Mechanisms?

Creators

  • 1. Hospital San Pedro
  • 2. Complejo Hospitalario de Navarra
  • 3. Clinica Universidad de Navarra
  • 4. Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

Description

DiagnosisThe diagnosis of CLL requires the presence of at least 5000 B lymphocytes/L in the peripheral blood (Hallek, et al 2008).CLL/SLL can be identified by the immunophenotype CD5+, CD10-, CD19+, CD20+, dim expression of surface immunoglobulin, CD23+, CD43 +/-, and cyclin D1- (Matutes, et al 2007).The absence of cyclin D1 is critical in distinguishing CLL/SLL from MCL. Bone marrow involvement is characteristically more than 30% of the nucleated cells in the aspirate are lymphoid.www.intechopen.

⚠️ This is an automatic machine translation with an accuracy of 90-95%

Translated Description (Arabic)

التشخيص يتطلب تشخيص CLL وجود ما لا يقل عن 5000 خلية ليمفاوية ب/لتر في الدم المحيطي (Hallek، et al 2008). يمكن تحديد CLL/SLL من خلال النمط الظاهري المناعي CD5 +، CD10 -، CD19 +، CD20 +، التعبير الخافت للغلوبولين المناعي السطحي، CD23 +، CD43 +/-، و cyclin D1 - (Matutes، et al 2007). يعد غياب cyclin D1 أمرًا بالغ الأهمية في التمييز بين CLL/SLL من MCL. تورط النخاع العظمي هو بشكل مميز أكثر من 30 ٪ من الخلايا النواة في الرشف هي الخلايا الليمفاوية. www.intechopen.

Translated Description (French)

DiagnosticLe diagnostic de LLC nécessite la présence d'au moins 5000 lymphocytes B/L dans le sang périphérique (Hallek, et al 2008) .La LLC/SLL peut être identifiée par l'immunophénotype CD5+, CD10-, CD19+, CD20+, l'expression faible de l'immunoglobuline de surface, CD23+, CD43 +/- et la cycline D1- (Matutes, et al 2007). L'absence de cycline D1 est essentielle pour distinguer la LLC/SLL de la MCL. L'atteinte de la moelle osseuse est caractérisée par le fait que plus de 30 % des cellules nucléées de l'aspirat sont lymphoïdes.www.intechopen.

Translated Description (Spanish)

DiagnósticoEl diagnóstico de CLL requiere la presencia de al menos 5000 linfocitos B/L en la sangre periférica (Hallek, et al 2008). CLL/SLL puede identificarse por el inmunofenotipo CD5+, CD10-, CD19+, CD20+, expresión dim de inmunoglobulina de superficie, CD23+, CD43 +/- y ciclina D1- (Matutes, et al 2007). La ausencia de ciclina D1 es fundamental para distinguir CLL/SLL de MCL. La afectación de la médula ósea es característicamente más del 30% de las células nucleadas en el aspirado son linfoides.www.intechopen.

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Additional details

Additional titles

Translated title (Arabic)
هل سرطان الدم الليمفاوي المزمن خطأ في آليات التسامح ؟
Translated title (French)
La leucémie lymphoïde chronique est-elle une erreur des mécanismes de tolérance ?
Translated title (Spanish)
¿Es la leucemia linfocítica crónica un error de los mecanismos de tolerancia?

Identifiers

Other
https://openalex.org/W1496596071
DOI
10.5772/37792

Is supplement to
https://openalex.org/W579273576 (Other)
https://openalex.org/W3108674512 (Other)
https://openalex.org/W3032375762 (Other)
https://openalex.org/W3031052312 (Other)
https://openalex.org/W2899084033 (Other)
https://openalex.org/W2748952813 (Other)
https://openalex.org/W2418031697 (Other)
https://openalex.org/W2080531066 (Other)
https://openalex.org/W1995515455 (Other)
https://openalex.org/W1506200166 (Other)

GreSIS Basics Section

Is Global South Knowledge
Yes
Country
Mexico

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