Published January 1, 2019
| Version v1
Publication
Pathophysiological mechanisms of diabetic cardiomyopathy and the therapeutic potential of epigallocatechin-3-gallate
- 1. Al-Hussein Bin Talal University
- 2. Beni-Suef University
Description
Cardiovascular complications are considered one of the leading causes of morbidity and mortality among diabetic patients. Diabetic cardiomyopathy (DCM) is a type of cardiovascular damage presents in diabetic patients independent of the coexistence of ischemic heart disease or hypertension. It is characterized by impaired diastolic relaxation time, myocardial dilatation and hypertrophy and reduced systolic and diastolic functions of the left ventricle. Molecular mechanisms underlying these pathological changes in the diabetic heart are most likely multifactorial and include, but not limited to, oxidative/nitrosative stress, increased advanced glycation end products, mitochondrial dysfunction, inflammation and cell death. The aim of this review is to address the major molecular mechanisms implicated in the pathogenesis of DCM. In addition, this review provides studies conducted to determine the pharmacological effects of (−)-epigallocatechin-3-gallate (EGCG), the major polyphenol in green tea, focusing on its therapeutic potential against the processes involved in the pathogenesis and progression of DCM. EGCG has been shown to exert several potential therapeutic properties both in vitro and in vivo. Given its therapeutic potential, EGCG might be a promising drug candidate to decrease the morbidity and mortality associated with DCM and other diabetes complications.
Translated Descriptions
⚠️
This is an automatic machine translation with an accuracy of 90-95%
Translated Description (Arabic)
تعتبر المضاعفات القلبية الوعائية أحد الأسباب الرئيسية للاعتلال والوفيات بين مرضى السكري. اعتلال عضلة القلب السكري (DCM) هو نوع من أضرار القلب والأوعية الدموية التي تظهر في مرضى السكري بشكل مستقل عن التعايش مع مرض القلب الإقفاري أو ارتفاع ضغط الدم. يتميز بضعف وقت الاسترخاء الانبساطي، وتوسع عضلة القلب والتضخم وانخفاض الوظائف الانقباضية والانبساطية للبطين الأيسر. من المرجح أن تكون الآليات الجزيئية الكامنة وراء هذه التغيرات المرضية في القلب السكري متعددة العوامل وتشمل، على سبيل المثال لا الحصر، الإجهاد التأكسدي/النتروجيني، وزيادة المنتجات النهائية المتقدمة للسكري، والخلل الوظيفي في الميتوكوندريا، والالتهاب وموت الخلايا. الهدف من هذه المراجعة هو معالجة الآليات الجزيئية الرئيسية المتورطة في التسبب في DCM. بالإضافة إلى ذلك، تقدم هذه المراجعة دراسات أجريت لتحديد الآثار الدوائية لـ (-) - epigallocatechin -3 - gallate (EGCG)، البوليفينول الرئيسي في الشاي الأخضر، مع التركيز على إمكاناته العلاجية ضد العمليات التي ينطوي عليها التسبب في المرض وتطور DCM. ثبت أن EGCG تمارس العديد من الخصائص العلاجية المحتملة في المختبر وفي الجسم الحي. نظرًا لإمكاناته العلاجية، قد يكون EGCG مرشحًا واعدًا للأدوية لتقليل المراضة والوفيات المرتبطة بـ DCM ومضاعفات السكري الأخرى.Translated Description (French)
Les complications cardiovasculaires sont considérées comme l'une des principales causes de morbidité et de mortalité chez les patients diabétiques. La cardiomyopathie diabétique (MCD) est un type de dommage cardiovasculaire présent chez les patients diabétiques indépendamment de la coexistence d'une cardiopathie ischémique ou d'une hypertension. Elle se caractérise par une altération du temps de relaxation diastolique, une dilatation et une hypertrophie du myocarde et une réduction des fonctions systolique et diastolique du ventricule gauche. Les mécanismes moléculaires sous-jacents à ces changements pathologiques dans le cœur diabétique sont très probablement multifactoriels et comprennent, mais sans s'y limiter, le stress oxydatif/nitrosatif, l'augmentation des produits finaux de glycation avancée, le dysfonctionnement mitochondrial, l'inflammation et la mort cellulaire. L'objectif de cette revue est d'aborder les principaux mécanismes moléculaires impliqués dans la pathogenèse du DCM. En outre, cette revue fournit des études menées pour déterminer les effets pharmacologiques du (−) -épigallocatéchine-3-gallate (EGCG), le polyphénol majeur du thé vert, en se concentrant sur son potentiel thérapeutique contre les processus impliqués dans la pathogenèse et la progression du DCM. Il a été démontré que l'EGCG exerce plusieurs propriétés thérapeutiques potentielles à la fois in vitro et in vivo. Compte tenu de son potentiel thérapeutique, l'EGCG pourrait être un candidat médicament prometteur pour diminuer la morbidité et la mortalité associées au DCM et à d'autres complications du diabète.Translated Description (Spanish)
Las complicaciones cardiovasculares se consideran una de las principales causas de morbilidad y mortalidad entre los pacientes diabéticos. La miocardiopatía diabética (MCD) es un tipo de daño cardiovascular presente en pacientes diabéticos independiente de la coexistencia de cardiopatía isquémica o hipertensión. Se caracteriza por un tiempo de relajación diastólica alterado, dilatación e hipertrofia del miocardio y funciones sistólicas y diastólicas reducidas del ventrículo izquierdo. Los mecanismos moleculares subyacentes a estos cambios patológicos en el corazón diabético son probablemente multifactoriales e incluyen, entre otros, estrés oxidativo/nitrosativo, aumento de los productos finales de glicación avanzada, disfunción mitocondrial, inflamación y muerte celular. El objetivo de esta revisión es abordar los principales mecanismos moleculares implicados en la patogénesis de la DCM. Además, esta revisión proporciona estudios realizados para determinar los efectos farmacológicos del (-)-epigalocatequina-3-galato (EGCG), el polifenol principal en el té verde, centrándose en su potencial terapéutico contra los procesos involucrados en la patogénesis y progresión de DCM. Se ha demostrado que el EGCG ejerce varias propiedades terapéuticas potenciales tanto in vitro como in vivo. Dado su potencial terapéutico, el EGCG podría ser un fármaco candidato prometedor para disminuir la morbilidad y mortalidad asociadas con la DCM y otras complicaciones de la diabetes.Additional details
Additional titles
- Translated title (Arabic)
- الآليات الفيزيولوجية المرضية لاعتلال عضلة القلب السكري والإمكانات العلاجية لـ epigallocatechin -3 - gallate
- Translated title (French)
- Mécanismes physiopathologiques de la cardiomyopathie diabétique et potentiel thérapeutique de l'épigallocatéchine-3-gallate
- Translated title (Spanish)
- Mecanismos fisiopatológicos de la miocardiopatía diabética y el potencial terapéutico de la epigalocatequina-3-galato
Identifiers
- Other
- https://openalex.org/W2903562879
- DOI
- 10.1016/j.biopha.2018.11.086
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