Published May 7, 2017 | Version v1
Publication Open

Pregnane steroids from the Vietnamese octocoral <i>Carijoa riisei</i>

Creators

  • 1. Vietnam Academy of Science and Technology
  • 2. Hanoi University of Science and Technology
  • 3. Institute of Marine Geology and Geophysics

Description

Six pregnane steroids including one new compound namely 15β-hydroxypregna-4,20-dien-3-one (1), were isolated and structurally elucidated from the octocoral Carijoa riisei. The cytotoxic activity against a panel of eight human cancer cell lines of isolated compounds was also evaluated by SRB method. As the results, 18-acetoxypregna-1,4,20-trien-3-one (5) showed significant cytotoxicity against all the tested cell lines with the IC50 values from 22.29 ± 1.47 to 48.73 ± 3.93 μM, whereas 15β-acetoxypregna-1,4,20-trien-3-one (3) and 20R-acetoxypregna-1,4-dien-3-one (6) only exhibited weak effect on KB cell line with IC50 values of 93.62 ± 7.32 and 71.38 ± 5.45 μM, respectively.

⚠️ This is an automatic machine translation with an accuracy of 90-95%

Translated Description (Arabic)

تم عزل ستة من الستيرويدات الحوامل بما في ذلك مركب جديد واحد وهو 15 β - hydroxypregna -4,20 - dien -3 - one (1)، وتم توضيحها هيكلياً من ثمانيات الفخذ Carijoa riisei. كما تم تقييم النشاط السام للخلايا ضد لوحة من ثمانية خطوط خلايا سرطانية بشرية من المركبات المعزولة بطريقة SRB. كما أظهرت النتائج، 18 - acetoxypregna -1،4،20 - trien -3 - one (5) سمية خلوية كبيرة ضد جميع خطوط الخلايا المختبرة بقيم IC50 من 22.29 ± 1.47 إلى 48.73 ± 3.93 ميكرومتر، في حين أن 15 β - acetoxypregna -1،4،20 - trien -3 - one (3) و 20 R - acetoxypregna -1،4 - dien -3 - one (6) أظهرت فقط تأثيرًا ضعيفًا على خط خلية KB بقيم IC50 93.62 ± 7.32 و 71.38 ± 5.45 ميكرومتر، على التوالي.

Translated Description (English)

Six pregnane steroids including one new compound namely 15β-hydroxypregna-4,20-dien-3-one (1), were isolated and structurally elucidated from the octocoral Carijoa riisei. The cytotoxic activity against a panel of eight human cancer cell lines of isolated compounds was also evaluated by SRB method. As the results, 18-acetoxypregna-1,4,20-trien-3-one (5) showed significant cytotoxicity against all the tested cell lines with the IC50 values from 22.29 ± 1.47 to 48.73 ± 3.93 μM, whereas 15β-acetoxypregna-1,4,20-trien-3-one (3) and 20R-acetoxypregna-1,4-dien-3-one (6) only exhibited weak effect on KB cell line with IC50 values of 93.62 ± 7.32 and 71.38 ± 5.45 μM, respectively.

Translated Description (French)

Six pregnane steroids including one new compound namely 15β-hydroxypregna-4,20-dien-3-one (1), were isolated and structurally élucidated from the octocoral Carijoa riisei. The cytotoxic activity against a panel of eight human cancer cell lines of isolated compounds was also evaluated by SRB method. As the results, 18-acetoxypregna-1,4,20-trien-3-one (5) showed significant cytotoxicity against all the tested cell lines with the IC50 values from 22.29 ± 1.47 to 48.73 ± 3.93 μM, whereas 15β-acetoxypregna-1,4,20-trien-3-one (3) and 20R-acetoxypregna-1,4-dien-3-one (6) only exhibited weak effect on KB cell line with IC50 values of 93.62 ± 7.32 and 71.38 ± 5.45 μM, respectivement.

Translated Description (Spanish)

Six pregnane steroids including one new compound namely 15β-hydroxypregna-4,20-dien-3-one (1), were isolated and structurally elucidated from the octocoral Carijoa riisei. The cytotoxic activity against a panel of eight human cancer cell lines of isolated compounds was also evaluated by SRB method. As the results, 18-acetoxypregna-1,4,20-trien-3-one (5) showed significant cytotoxicity against all the tested cell lines with the IC50 values from 22.29 ± 1.47 to 48.73 ± 3.93 μM, whereas 15β-acetoxypregna-1,4,20-trien-3-one (3) and 20R-acetoxypregna-1,4-dien-3-one (6) only exhibited weak effect on KB cell line with IC50 values of 93.62 ± 7.32 and 71.38 ± 5.45 μM, respectively.

Files

8386820.pdf.pdf

Files (940.2 kB)

⚠️ Please wait a few minutes before your translated files are ready ⚠️ Note: Some files might be protected thus translations might not work.
Name Size Download all
md5:fe2257c750dde7f163e8be5e89bb3879
940.2 kB
Preview Download

Additional details

Additional titles

Translated title (Arabic)
ستيرويدات بريجنان من <i>كاريجوا</i> ريزي الثماني الفيتنامي
Translated title (English)
Pregnane steroids from the Vietnamese octocoral <i>Carijoa riisei</i>
Translated title (French)
Pregnane steroids from the Vietnamese octocoral <i>Carijoa riisei</i>
Translated title (Spanish)
Pregnane steroids from the Vietnamese octocoral <i>Carijoa riisei</i>

Identifiers

Other
https://openalex.org/W2612350461
DOI
10.1080/14786419.2017.1324964

Is supplement to
https://openalex.org/W4205913757 (Other)
https://openalex.org/W3128095928 (Other)
https://openalex.org/W2441562023 (Other)
https://openalex.org/W2115137911 (Other)
https://openalex.org/W2075857984 (Other)
https://openalex.org/W2027032818 (Other)
https://openalex.org/W2005397924 (Other)
https://openalex.org/W2004105127 (Other)
https://openalex.org/W1701486583 (Other)
https://openalex.org/W1596282403 (Other)

GreSIS Basics Section

Is Global South Knowledge
Yes
Country
Vietnam

References

  • https://openalex.org/W1771782040
  • https://openalex.org/W1972813582
  • https://openalex.org/W2007664991
  • https://openalex.org/W2023450397
  • https://openalex.org/W2027158151
  • https://openalex.org/W2061584312
  • https://openalex.org/W2109689528
  • https://openalex.org/W2179741461
  • https://openalex.org/W2306515551
  • https://openalex.org/W2329527950
  • https://openalex.org/W2347125076
  • https://openalex.org/W2578619595
  • https://openalex.org/W2951855235