Published August 23, 2022 | Version v1
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Three new α-glucosidase inhibitor benzo-isochromenes from <i>Datura stramonium</i>

Creators

  • 1. Gomal University
  • 2. Balochistan University of Information Technology, Engineering and Management Sciences

Description

Three new α-glucosidase inhibitory benzo-isochromenes were isolated from the chloroform fraction of Datura stramonium. Their structures were established with the help of modern spectroscopic techniques and were assigned the names as 1,6,8-triimethoxy-2-methyl-3,4-dihydrobenzoisochromene-5,10-diol, 3,6-dimethoxy-5-hydroxy-4-methylbenzoisochromene-9,11-dione and demethylflavasperon for compounds 1-3 respectively. The α-glucosidase inhibiting activity of compound 2 showed strong inhibition with an IC50 value of 27.5 µM, while compound 1 exhibited moderate activity with IC50 value of 60.2 µM compared to positive control (acarbose).

⚠️ This is an automatic machine translation with an accuracy of 90-95%

Translated Description (Arabic)

تم عزل ثلاثة بنزو أيزوكرومينات مثبطة α - glucosidase جديدة من جزء الكلوروفورم من داتورا سترامونيوم. تم إنشاء هياكلها بمساعدة التقنيات الطيفية الحديثة وتم تعيين الأسماء على أنها 1،6،8 - triimethoxy -2 - methyl -3،4 - dihydrobenzoisochromene -5،10 - diol و 3،6 - dimethoxy -5 - hydroxy -4 - methylbenzoisochromene -9،11 - dione و demethylflavasperon للمركبات 1-3 على التوالي. أظهر نشاط تثبيط α - glucosidase للمركب 2 تثبيطًا قويًا بقيمة IC50 تبلغ 27.5 ميكرومتر، بينما أظهر المركب 1 نشاطًا معتدلًا بقيمة IC50 تبلغ 60.2 ميكرومتر مقارنة بالتحكم الإيجابي (acarbose).

Translated Description (French)

Trois nouveaux benzo-isochromènes inhibiteurs de l'α-glucosidase ont été isolés de la fraction chloroforme de Datura stramonium. Leurs structures ont été établies à l'aide de techniques spectroscopiques modernes et on leur a attribué les noms de 1,6,8-triiméthoxy-2-méthyl-3,4-dihydrobenzoisochromène-5,10-diol, 3,6-diméthoxy-5-hydroxy-4-méthylbenzoisochromène-9,11-dione et déméthylflavasperon pour les composés 1-3 respectivement. L'activité inhibitrice de l'α-glucosidase du composé 2 a montré une forte inhibition avec une valeur IC50 de 27,5 µM, tandis que le composé 1 présentait une activité modérée avec une valeur IC50 de 60,2 µM par rapport au contrôle positif (acarbose).

Translated Description (Spanish)

Se aislaron tres nuevos benzoisocromenos inhibidores de α-glucosidasa de la fracción de cloroformo de Datura stramonium. Sus estructuras se establecieron con la ayuda de técnicas espectroscópicas modernas y se les asignaron los nombres de 1,6,8-triimetoxi-2-metil-3,4-dihidrobenzoisocromeno-5,10-diol, 3,6-dimetoxi-5-hidroxi-4-metilbenzoisocromeno-9,11-diona y desmetilflavasperona para los compuestos 1-3, respectivamente. La actividad inhibidora de α-glucosidasa del compuesto 2 mostró una fuerte inhibición con un valor de IC50 de 27.5 µM, mientras que el compuesto 1 mostró una actividad moderada con un valor de IC50 de 60.2 µM en comparación con el control positivo (acarbosa).

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Additional details

Additional titles

Translated title (Arabic)
ثلاثة مثبطات جديدة α - glucosidase بنزو أيزوكرومينات من <i>داتورا سترامونيوم</i>
Translated title (French)
Trois nouveaux benzo-isochromènes inhibiteurs de l'α-glucosidase de <i>Datura stramonium</i>
Translated title (Spanish)
Tres nuevos benzoisocromenos inhibidores de α-glucosidasa de <i>Datura stramonium</i>

Identifiers

Other
https://openalex.org/W4293214592
DOI
10.1080/14786419.2022.2116020

Is supplement to
https://openalex.org/W4283574253 (Other)
https://openalex.org/W4226516178 (Other)
https://openalex.org/W3204418718 (Other)
https://openalex.org/W3102134332 (Other)
https://openalex.org/W3087723073 (Other)
https://openalex.org/W2775413683 (Other)
https://openalex.org/W2739400591 (Other)
https://openalex.org/W2589406108 (Other)
https://openalex.org/W2386875915 (Other)
https://openalex.org/W2181376415 (Other)

GreSIS Basics Section

Is Global South Knowledge
Yes
Country
Pakistan

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