Published January 1, 2010
| Version v1
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Diet and Age Interactions with Regards to Cholesterol Regulation and Brain Pathogenesis
- 1. Universidad Nacional del Sur
- 2. Pennington Biomedical Research Center
- 3. Louisiana State University System
Description
Cholesterol is an essential molecule for brain homeostasis; yet, hypercholesterolemia and its numerous complications are believed to play a role in promoting multiple aspects of brain pathogenesis. An ever increasing number of individuals in modern Western Society are regularly consuming diets high in fat which promote the development of hypercholesterolemia. Additionally, modern societies are becoming increasingly aged, causing a collision between increased hypercholesterolemia and increased aging, which will likely lead to the development of increased pathological conditions due to hypercholesterolemia, thereby promoting deleterious neurochemical and behavioral changes in the brain. Lastly, while beneficial in controlling cholesterol levels, the long-term use of statins itself may potentially promote adverse effects on brain homeostasis, although specifics on this remain largely unknown. This review will focus on linking the current understanding of diet-induced hypercholesterolemia (as well as statin use) to the development of oxidative stress, neurochemical alterations, and cognitive disturbances in the aging brain.
Translated Descriptions
⚠️
This is an automatic machine translation with an accuracy of 90-95%
Translated Description (Arabic)
الكوليسترول هو جزيء أساسي لتوازن الدماغ ؛ ومع ذلك، يُعتقد أن فرط الكوليسترول في الدم ومضاعفاته العديدة يلعب دورًا في تعزيز جوانب متعددة من التسبب في أمراض الدماغ. يستهلك عدد متزايد من الأفراد في المجتمع الغربي الحديث بانتظام وجبات غذائية غنية بالدهون مما يعزز تطور فرط كوليسترول الدم. بالإضافة إلى ذلك، أصبحت المجتمعات الحديثة تشيخ بشكل متزايد، مما تسبب في تصادم بين زيادة فرط كوليسترول الدم وزيادة الشيخوخة، مما سيؤدي على الأرجح إلى تطور حالات مرضية متزايدة بسبب فرط كوليسترول الدم، وبالتالي تعزيز التغيرات الكيميائية العصبية والسلوكية الضارة في الدماغ. أخيرًا، على الرغم من أنه مفيد في التحكم في مستويات الكوليسترول، إلا أن الاستخدام طويل الأجل للستاتين نفسه قد يعزز الآثار الضارة على توازن الدماغ، على الرغم من أن التفاصيل المتعلقة بذلك لا تزال غير معروفة إلى حد كبير. ستركز هذه المراجعة على ربط الفهم الحالي لفرط كوليسترول الدم الناجم عن النظام الغذائي (بالإضافة إلى استخدام الستاتين) بتطور الإجهاد التأكسدي والتغيرات الكيميائية العصبية والاضطرابات المعرفية في شيخوخة الدماغ.Translated Description (French)
Le cholestérol est une molécule essentielle pour l'homéostasie cérébrale ; pourtant, on pense que l'hypercholestérolémie et ses nombreuses complications jouent un rôle dans la promotion de multiples aspects de la pathogenèse cérébrale. Un nombre toujours croissant d'individus dans la société occidentale moderne consomment régulièrement des régimes riches en graisses qui favorisent le développement de l'hypercholestérolémie. De plus, les sociétés modernes vieillissent de plus en plus, provoquant une collision entre une hypercholestérolémie accrue et un vieillissement accru, ce qui entraînera probablement le développement de conditions pathologiques accrues dues à l'hypercholestérolémie, favorisant ainsi des changements neurochimiques et comportementaux délétères dans le cerveau. Enfin, bien qu'elle soit bénéfique pour contrôler les taux de cholestérol, l'utilisation à long terme des statines elle-même peut potentiellement favoriser des effets indésirables sur l'homéostasie cérébrale, bien que les détails à ce sujet restent largement inconnus. Cette revue se concentrera sur le lien entre la compréhension actuelle de l'hypercholestérolémie induite par l'alimentation (ainsi que l'utilisation des statines) et le développement du stress oxydatif, des altérations neurochimiques et des troubles cognitifs dans le cerveau vieillissant.Translated Description (Spanish)
El colesterol es una molécula esencial para la homeostasis cerebral; sin embargo, se cree que la hipercolesterolemia y sus numerosas complicaciones desempeñan un papel en la promoción de múltiples aspectos de la patogénesis cerebral. Un número cada vez mayor de personas en la sociedad occidental moderna consumen regularmente dietas ricas en grasas que promueven el desarrollo de hipercolesterolemia. Además, las sociedades modernas están envejeciendo cada vez más, causando una colisión entre el aumento de la hipercolesterolemia y el aumento del envejecimiento, lo que probablemente conducirá al desarrollo de un aumento de las condiciones patológicas debido a la hipercolesterolemia, promoviendo así cambios neuroquímicos y de comportamiento perjudiciales en el cerebro. Por último, aunque es beneficioso para controlar los niveles de colesterol, el uso a largo plazo de las estatinas en sí puede promover efectos adversos en la homeostasis cerebral, aunque los detalles sobre esto siguen siendo en gran parte desconocidos. Esta revisión se centrará en vincular la comprensión actual de la hipercolesterolemia inducida por la dieta (así como el uso de estatinas) con el desarrollo del estrés oxidativo, las alteraciones neuroquímicas y las alteraciones cognitivas en el cerebro que envejece.Files
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Additional details
Additional titles
- Translated title (Arabic)
- النظام الغذائي والتفاعلات العمرية فيما يتعلق بتنظيم الكوليسترول وإمراض الدماغ
- Translated title (French)
- Interactions entre l'alimentation et l'âge en ce qui concerne la régulation du cholestérol et la pathogenèse cérébrale
- Translated title (Spanish)
- Interacciones de la dieta y la edad con respecto a la regulación del colesterol y la patogénesis cerebral
Identifiers
- Other
- https://openalex.org/W2039745403
- DOI
- 10.1155/2010/219683
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