Published April 25, 2018 | Version v1
Publication Open

Immediate Early Genes, Memory and Psychiatric Disorders: Focus on c-Fos, Egr1 and Arc

Creators

  • 1. University of Buenos Aires
  • 2. Consejo Nacional de Investigaciones Científicas y Técnicas

Description

Many psychiatric disorders, despite their specific characteristics, share deficits in the cognitive domain including executive functions, emotional control and memory. However, memory deficits have been in many cases undervalued compared with other characteristics. The expression of Immediate Early Genes (IEGs) such as, c-fos, Egr1 and arc are selectively and promptly upregulated in learning and memory among neuronal subpopulations in regions associated with these processes. Changes in expression in these genes have been observed in recognition, working and fear related memories across the brain. Despite the enormous amount of data supporting changes in their expression during learning and memory and the importance of those cognitive processes in psychiatric conditions, there are very few studies analyzing the direct implication of the IEGs in mental illnesses. In this review, we discuss the role of some of the most relevant IEGs in relation with memory processes affected in psychiatric conditions.

⚠️ This is an automatic machine translation with an accuracy of 90-95%

Translated Description (Arabic)

تشترك العديد من الاضطرابات النفسية، على الرغم من خصائصها المحددة، في عجز في المجال المعرفي بما في ذلك الوظائف التنفيذية والتحكم العاطفي والذاكرة. ومع ذلك، فقد تم تقدير عجز الذاكرة في كثير من الحالات بأقل من قيمته مقارنة بالخصائص الأخرى. يتم تنظيم التعبير عن الجينات المبكرة الفورية (IEGs) مثل c - fos و Egr1 و ARC بشكل انتقائي وسريع في التعلم والذاكرة بين المجموعات الفرعية العصبية في المناطق المرتبطة بهذه العمليات. وقد لوحظت تغييرات في التعبير في هذه الجينات في التعرف والعمل والذكريات المتعلقة بالخوف في جميع أنحاء الدماغ. على الرغم من الكم الهائل من البيانات التي تدعم التغييرات في التعبير عنها أثناء التعلم والذاكرة وأهمية تلك العمليات المعرفية في الحالات النفسية، هناك عدد قليل جدًا من الدراسات التي تحلل الآثار المباشرة للدماغ في الأمراض العقلية. في هذه المراجعة، نناقش دور بعض IEGs الأكثر صلة فيما يتعلق بعمليات الذاكرة المتأثرة في الحالات النفسية.

Translated Description (French)

De nombreux troubles psychiatriques, malgré leurs caractéristiques spécifiques, partagent des déficits dans le domaine cognitif, y compris les fonctions exécutives, le contrôle émotionnel et la mémoire. Cependant, les déficits de mémoire ont été dans de nombreux cas sous-évalués par rapport à d'autres caractéristiques. L'expression des gènes précoces immédiats (IEG) tels que c-fos, Egr1 et arc est régulée sélectivement et rapidement à la hausse dans l'apprentissage et la mémoire parmi les sous-populations neuronales dans les régions associées à ces processus. Des changements dans l'expression de ces gènes ont été observés dans la reconnaissance, le travail et les souvenirs liés à la peur dans le cerveau. Malgré l'énorme quantité de données soutenant les changements dans leur expression pendant l'apprentissage et la mémoire et l'importance de ces processus cognitifs dans les conditions psychiatriques, très peu d'études analysent l'implication directe des GEI dans les maladies mentales. Dans cette revue, nous discutons du rôle de certains des GEI les plus pertinents en relation avec les processus de mémoire affectés dans les conditions psychiatriques.

Translated Description (Spanish)

Muchos trastornos psiquiátricos, a pesar de sus características específicas, comparten déficits en el dominio cognitivo, incluidas las funciones ejecutivas, el control emocional y la memoria. Sin embargo, los déficits de memoria han sido en muchos casos infravalorados en comparación con otras características. La expresión de genes tempranos inmediatos (IEG) como, c-fos, Egr1 y ARC se regula selectiva y rápidamente en el aprendizaje y la memoria entre las subpoblaciones neuronales en regiones asociadas con estos procesos. Se han observado cambios en la expresión de estos genes en los recuerdos relacionados con el reconocimiento, el trabajo y el miedo en todo el cerebro. A pesar de la enorme cantidad de datos que respaldan los cambios en su expresión durante el aprendizaje y la memoria y la importancia de esos procesos cognitivos en las afecciones psiquiátricas, hay muy pocos estudios que analicen la implicación directa de los IEG en las enfermedades mentales. En esta revisión, discutimos el papel de algunos de los IEG más relevantes en relación con los procesos de memoria afectados en condiciones psiquiátricas.

Files

pdf.pdf

Files (1.1 MB)

⚠️ Please wait a few minutes before your translated files are ready ⚠️ Note: Some files might be protected thus translations might not work.
Name Size Download all
md5:41dfc8a275945f07fa2a6541ad02c33a
1.1 MB
Preview Download

Additional details

Additional titles

Translated title (Arabic)
الجينات المبكرة الفورية والذاكرة والاضطرابات النفسية: التركيز على c - Fos و Egr1 و ARC
Translated title (French)
Gènes précoces immédiats, mémoire et troubles psychiatriques : focus sur c-Fos, Egr1 et Arc
Translated title (Spanish)
Genes Tempranos Inmediatos, Memoria y Trastornos Psiquiátricos: Enfoque en c-Fos, Egr1 y ARC

Identifiers

Other
https://openalex.org/W2802172273
DOI
10.3389/fnbeh.2018.00079

Is supplement to
https://openalex.org/W4363648628 (Other)
https://openalex.org/W3213745692 (Other)
https://openalex.org/W2167854883 (Other)
https://openalex.org/W2162591320 (Other)
https://openalex.org/W2094780410 (Other)
https://openalex.org/W2071325834 (Other)
https://openalex.org/W2000627810 (Other)
https://openalex.org/W1994011542 (Other)
https://openalex.org/W1978122462 (Other)
https://openalex.org/W1902811311 (Other)

GreSIS Basics Section

Is Global South Knowledge
Yes
Country
Argentina

References

  • https://openalex.org/W104526663
  • https://openalex.org/W130939806
  • https://openalex.org/W1488313827
  • https://openalex.org/W1496673335
  • https://openalex.org/W1503879678
  • https://openalex.org/W1523637894
  • https://openalex.org/W1552458995
  • https://openalex.org/W1562926869
  • https://openalex.org/W1575531743
  • https://openalex.org/W1580730946
  • https://openalex.org/W1607671357
  • https://openalex.org/W1675950512
  • https://openalex.org/W1698044858
  • https://openalex.org/W1781131011
  • https://openalex.org/W1819450238
  • https://openalex.org/W1820544323
  • https://openalex.org/W1821495885
  • https://openalex.org/W1841306819
  • https://openalex.org/W1847132166
  • https://openalex.org/W185588358
  • https://openalex.org/W195367813
  • https://openalex.org/W1961885071
  • https://openalex.org/W1963628765
  • https://openalex.org/W1965627514
  • https://openalex.org/W1965726907
  • https://openalex.org/W1965970232
  • https://openalex.org/W1969212642
  • https://openalex.org/W1969678755
  • https://openalex.org/W1969709016
  • https://openalex.org/W1970477245
  • https://openalex.org/W1973235292
  • https://openalex.org/W1973840419
  • https://openalex.org/W1974476511
  • https://openalex.org/W1974865784
  • https://openalex.org/W1976411733
  • https://openalex.org/W1976750232
  • https://openalex.org/W1977997693
  • https://openalex.org/W1978343268
  • https://openalex.org/W1979191631
  • https://openalex.org/W1979990523
  • https://openalex.org/W1980452424
  • https://openalex.org/W1980717857
  • https://openalex.org/W1981568616
  • https://openalex.org/W1984767179
  • https://openalex.org/W1985513583
  • https://openalex.org/W1986577155
  • https://openalex.org/W1986624071
  • https://openalex.org/W1989426007
  • https://openalex.org/W1989545342
  • https://openalex.org/W1990644868
  • https://openalex.org/W1990808724
  • https://openalex.org/W1991036243
  • https://openalex.org/W1991159843
  • https://openalex.org/W1991330295
  • https://openalex.org/W1992070757
  • https://openalex.org/W1992222970
  • https://openalex.org/W1993959248
  • https://openalex.org/W1994611219
  • https://openalex.org/W1995811027
  • https://openalex.org/W1996297724
  • https://openalex.org/W1996589480
  • https://openalex.org/W1996838710
  • https://openalex.org/W1996860397
  • https://openalex.org/W1996881939
  • https://openalex.org/W1996900694
  • https://openalex.org/W1997137464
  • https://openalex.org/W1997627588
  • https://openalex.org/W1998389513
  • https://openalex.org/W1998394223
  • https://openalex.org/W2000366839
  • https://openalex.org/W2000402944
  • https://openalex.org/W2001508917
  • https://openalex.org/W2002282047
  • https://openalex.org/W2003136437
  • https://openalex.org/W2003443050
  • https://openalex.org/W2004030282
  • https://openalex.org/W2005720817
  • https://openalex.org/W2005862509
  • https://openalex.org/W2006159608
  • https://openalex.org/W2007816528
  • https://openalex.org/W2009129022
  • https://openalex.org/W2009138589
  • https://openalex.org/W2009854865
  • https://openalex.org/W2010653960
  • https://openalex.org/W2011889986
  • https://openalex.org/W2013185658
  • https://openalex.org/W2014920515
  • https://openalex.org/W2017244291
  • https://openalex.org/W2017816448
  • https://openalex.org/W2018114747
  • https://openalex.org/W2020469828
  • https://openalex.org/W2020636839
  • https://openalex.org/W2020778578
  • https://openalex.org/W2021885143
  • https://openalex.org/W2021894381
  • https://openalex.org/W2022564992
  • https://openalex.org/W2025096365
  • https://openalex.org/W2025204726
  • https://openalex.org/W2027162857
  • https://openalex.org/W2027429490
  • https://openalex.org/W2027877806
  • https://openalex.org/W2028028623
  • https://openalex.org/W2029087007
  • https://openalex.org/W2029687467
  • https://openalex.org/W2030643622
  • https://openalex.org/W2030735742
  • https://openalex.org/W2031056019
  • https://openalex.org/W2031516346
  • https://openalex.org/W2032162985
  • https://openalex.org/W2032658084
  • https://openalex.org/W2034129855
  • https://openalex.org/W2035384082
  • https://openalex.org/W2035856041
  • https://openalex.org/W2036747186
  • https://openalex.org/W2037155998
  • https://openalex.org/W2037231975
  • https://openalex.org/W2038989697
  • https://openalex.org/W2039881583
  • https://openalex.org/W2040193459
  • https://openalex.org/W2040714251
  • https://openalex.org/W2040980418
  • https://openalex.org/W2041101385
  • https://openalex.org/W2041915527
  • https://openalex.org/W2042834556
  • https://openalex.org/W2044443692
  • https://openalex.org/W2045494953
  • https://openalex.org/W2045602057
  • https://openalex.org/W2049038171
  • https://openalex.org/W2049441423
  • https://openalex.org/W2049549817
  • https://openalex.org/W2049704911
  • https://openalex.org/W2050552159
  • https://openalex.org/W2052977964
  • https://openalex.org/W2054228210
  • https://openalex.org/W2055775594
  • https://openalex.org/W2055852552
  • https://openalex.org/W2057059034
  • https://openalex.org/W2057118510
  • https://openalex.org/W2058601367
  • https://openalex.org/W2058744360
  • https://openalex.org/W2058877345
  • https://openalex.org/W2058980740
  • https://openalex.org/W2060160772
  • https://openalex.org/W2060468913
  • https://openalex.org/W2060645936
  • https://openalex.org/W2061233919
  • https://openalex.org/W2061404207
  • https://openalex.org/W2061694006
  • https://openalex.org/W2062102986
  • https://openalex.org/W2062767067
  • https://openalex.org/W2063051897
  • https://openalex.org/W2063638513
  • https://openalex.org/W2063990250
  • https://openalex.org/W2066029568
  • https://openalex.org/W2067352668
  • https://openalex.org/W2069094890
  • https://openalex.org/W2070250157
  • https://openalex.org/W2071148558
  • https://openalex.org/W2071306520
  • https://openalex.org/W2072329780
  • https://openalex.org/W2073145989
  • https://openalex.org/W2073357074
  • https://openalex.org/W2075754305
  • https://openalex.org/W2076248338
  • https://openalex.org/W2080269340
  • https://openalex.org/W2080615842
  • https://openalex.org/W2080822716
  • https://openalex.org/W2082235945
  • https://openalex.org/W2082790613
  • https://openalex.org/W2083207963
  • https://openalex.org/W2083646860
  • https://openalex.org/W2084002946
  • https://openalex.org/W2084577318
  • https://openalex.org/W2085710872
  • https://openalex.org/W2088863821
  • https://openalex.org/W2088910742
  • https://openalex.org/W2089406505
  • https://openalex.org/W2090755410
  • https://openalex.org/W2090954164
  • https://openalex.org/W2091064369
  • https://openalex.org/W2091271382
  • https://openalex.org/W2091497325
  • https://openalex.org/W2091913032
  • https://openalex.org/W2091971881
  • https://openalex.org/W2093359244
  • https://openalex.org/W2093571519
  • https://openalex.org/W2094056330
  • https://openalex.org/W2094420852
  • https://openalex.org/W2094780410
  • https://openalex.org/W2094994812
  • https://openalex.org/W2097983973
  • https://openalex.org/W2098532348
  • https://openalex.org/W2098551858
  • https://openalex.org/W2100172973
  • https://openalex.org/W2101995552
  • https://openalex.org/W2102973376
  • https://openalex.org/W2103791867
  • https://openalex.org/W2104093313
  • https://openalex.org/W2104742248
  • https://openalex.org/W2105094581
  • https://openalex.org/W2106623141
  • https://openalex.org/W2108995240
  • https://openalex.org/W2109237775
  • https://openalex.org/W2114559471
  • https://openalex.org/W2114858241
  • https://openalex.org/W2115064581
  • https://openalex.org/W2115736681
  • https://openalex.org/W2117408205
  • https://openalex.org/W2119622757
  • https://openalex.org/W2120020525
  • https://openalex.org/W2121198501
  • https://openalex.org/W2121852278
  • https://openalex.org/W2122682406
  • https://openalex.org/W2127550021
  • https://openalex.org/W2129237942
  • https://openalex.org/W2129902706
  • https://openalex.org/W2131370784
  • https://openalex.org/W2131612765
  • https://openalex.org/W2134623571
  • https://openalex.org/W2135214271
  • https://openalex.org/W2136096486
  • https://openalex.org/W2137313711
  • https://openalex.org/W2137526341
  • https://openalex.org/W2141265667
  • https://openalex.org/W2141391979
  • https://openalex.org/W2141664721
  • https://openalex.org/W2146205533
  • https://openalex.org/W2146460558
  • https://openalex.org/W2146902247
  • https://openalex.org/W2147575654
  • https://openalex.org/W2150596589
  • https://openalex.org/W2153292144
  • https://openalex.org/W2153525031
  • https://openalex.org/W2155389918
  • https://openalex.org/W2155505956
  • https://openalex.org/W2155968662
  • https://openalex.org/W2156746271
  • https://openalex.org/W2156809536
  • https://openalex.org/W2157468016
  • https://openalex.org/W2159447534
  • https://openalex.org/W2161234653
  • https://openalex.org/W2162052978
  • https://openalex.org/W2162356040
  • https://openalex.org/W2162584238
  • https://openalex.org/W2162591320
  • https://openalex.org/W2167194856
  • https://openalex.org/W2167423431
  • https://openalex.org/W2167604659
  • https://openalex.org/W2168136532
  • https://openalex.org/W2169471345
  • https://openalex.org/W2169901628
  • https://openalex.org/W2172149172
  • https://openalex.org/W2174265254
  • https://openalex.org/W2183998942
  • https://openalex.org/W2206644343
  • https://openalex.org/W2209554327
  • https://openalex.org/W2224527671
  • https://openalex.org/W2256253694
  • https://openalex.org/W2280881439
  • https://openalex.org/W2311206429
  • https://openalex.org/W2325783815
  • https://openalex.org/W2336055593
  • https://openalex.org/W2346924109
  • https://openalex.org/W2349918789
  • https://openalex.org/W2374436361
  • https://openalex.org/W2402914320
  • https://openalex.org/W2410350488
  • https://openalex.org/W2412515870
  • https://openalex.org/W2414029684
  • https://openalex.org/W2417710887
  • https://openalex.org/W2507319453
  • https://openalex.org/W2513781505
  • https://openalex.org/W2517001916
  • https://openalex.org/W2532438593
  • https://openalex.org/W2539965696
  • https://openalex.org/W2559772671
  • https://openalex.org/W2576224678
  • https://openalex.org/W2578178211
  • https://openalex.org/W2595255406
  • https://openalex.org/W2603258172
  • https://openalex.org/W2624545944
  • https://openalex.org/W2754485950
  • https://openalex.org/W2769076075
  • https://openalex.org/W276958651
  • https://openalex.org/W2782939777
  • https://openalex.org/W2783435551
  • https://openalex.org/W2899545275
  • https://openalex.org/W4211021876
  • https://openalex.org/W4229793598
  • https://openalex.org/W4229800423
  • https://openalex.org/W4233599153
  • https://openalex.org/W4235693988
  • https://openalex.org/W806751051