Published May 16, 2018 | Version v1
Publication Open

Regulatory and Mechanistic Actions of Glucocorticoids on T and Inflammatory Cells

Creators

  • 1. Biomedicine Research Institute of Buenos Aires - CONICET - Partner Institute of the Max Planck Society
  • 2. Fundación Ciencias Exactas y Naturales
  • 3. University of Buenos Aires

Description

Glucocorticoids (GCs) play an important role in regulating the inflammatory and immune response and have been used since decades to treat various inflammatory and autoimmune disorders. Fine-tuning the glucocorticoid receptor (GR) activity is instrumental in the search for novel therapeutic strategies aimed to reduce pathological signaling and restoring homeostasis. Despite the primary anti-inflammatory actions of GCs, there are studies suggesting that under certain conditions GCs may also exert pro-inflammatory responses. For these reasons the understanding of the GR basic mechanisms of action on different immune cells in the periphery (e.g., macrophages, dendritic cells, neutrophils, and T cells) and in the brain (microglia) contexts, that we review in this chapter, is a continuous matter of interest and may reveal novel therapeutic targets for the treatment of immune and inflammatory response.

⚠️ This is an automatic machine translation with an accuracy of 90-95%

Translated Description (Arabic)

تلعب الكورتيكويدات السكرية (GCs) دورًا مهمًا في تنظيم الاستجابة الالتهابية والمناعية وقد استخدمت منذ عقود لعلاج مختلف اضطرابات الالتهاب والمناعة الذاتية. يعد الضبط الدقيق لنشاط مستقبلات القشرانيات السكرية (GR) مفيدًا في البحث عن استراتيجيات علاجية جديدة تهدف إلى تقليل الإشارات المرضية واستعادة التوازن. على الرغم من الإجراءات الأولية المضادة للالتهابات من GCs، هناك دراسات تشير إلى أنه في ظل ظروف معينة قد تمارس GCs أيضًا استجابات مؤيدة للالتهابات. لهذه الأسباب، فإن فهم آليات العمل الأساسية لـ GR على الخلايا المناعية المختلفة في المحيط (على سبيل المثال، البلاعم، والخلايا التغصنية، والعدلات، والخلايا التائية) وفي سياقات الدماغ (الخلايا الدبقية الدقيقة)، التي نستعرضها في هذا الفصل، هي مسألة مستمرة ذات أهمية وقد تكشف عن أهداف علاجية جديدة لعلاج الاستجابة المناعية والالتهابية.

Translated Description (French)

Les glucocorticoïdes (GC) jouent un rôle important dans la régulation de la réponse inflammatoire et immunitaire et sont utilisés depuis des décennies pour traiter diverses maladies inflammatoires et auto-immunes. Le réglage fin de l'activité du récepteur des glucocorticoïdes (GR) est essentiel dans la recherche de nouvelles stratégies thérapeutiques visant à réduire la signalisation pathologique et à restaurer l'homéostasie. Malgré les actions anti-inflammatoires primaires des CG, des études suggèrent que, dans certaines conditions, les CG peuvent également exercer des réponses pro-inflammatoires. Pour ces raisons, la compréhension des mécanismes d'action de base des GR sur différentes cellules immunitaires à la périphérie (par exemple, les macrophages, les cellules dendritiques, les neutrophiles et les cellules T) et dans le cerveau (microglie), que nous examinons dans ce chapitre, est un sujet d'intérêt continu et peut révéler de nouvelles cibles thérapeutiques pour le traitement de la réponse immunitaire et inflammatoire.

Translated Description (Spanish)

Los glucocorticoides (GC) desempeñan un papel importante en la regulación de la respuesta inflamatoria e inmune y se han utilizado desde hace décadas para tratar diversos trastornos inflamatorios y autoinmunes. El ajuste de la actividad del receptor de glucocorticoides (GR) es fundamental en la búsqueda de nuevas estrategias terapéuticas destinadas a reducir la señalización patológica y restaurar la homeostasis. A pesar de las acciones antiinflamatorias primarias de los GC, hay estudios que sugieren que, bajo ciertas condiciones, los GC también pueden ejercer respuestas proinflamatorias. Por estas razones, la comprensión de los mecanismos básicos de acción de GR en diferentes células inmunitarias en la periferia (por ejemplo, macrófagos, células dendríticas, neutrófilos y células T) y en el contexto cerebral (microglía), que revisamos en este capítulo, es un asunto de interés continuo y puede revelar nuevas dianas terapéuticas para el tratamiento de la respuesta inmunitaria e inflamatoria.

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Additional details

Additional titles

Translated title (Arabic)
الإجراءات التنظيمية والميكانيكية للكورتيكويدات السكرية على الخلايا التائية والالتهابية
Translated title (French)
Actions régulatrices et mécaniques des glucocorticoïdes sur les cellules T et inflammatoires
Translated title (Spanish)
Acciones reguladoras y mecanicistas de los glucocorticoides sobre las células T e inflamatorias

Identifiers

Other
https://openalex.org/W2800565928
DOI
10.3389/fendo.2018.00235

Is supplement to
https://openalex.org/W4318460051 (Other)
https://openalex.org/W269771094 (Other)
https://openalex.org/W2436275868 (Other)
https://openalex.org/W2359066614 (Other)
https://openalex.org/W2338237228 (Other)
https://openalex.org/W2119824100 (Other)
https://openalex.org/W2070579680 (Other)
https://openalex.org/W2027214458 (Other)
https://openalex.org/W1981540681 (Other)
https://openalex.org/W1578882671 (Other)

GreSIS Basics Section

Is Global South Knowledge
Yes
Country
Argentina

References

  • https://openalex.org/W1485545593
  • https://openalex.org/W1517353469
  • https://openalex.org/W1519063308
  • https://openalex.org/W1522773084
  • https://openalex.org/W1552210756
  • https://openalex.org/W1553271826
  • https://openalex.org/W1574387337
  • https://openalex.org/W1593219141
  • https://openalex.org/W1605768991
  • https://openalex.org/W1633895660
  • https://openalex.org/W1760516212
  • https://openalex.org/W1844780367
  • https://openalex.org/W1906626576
  • https://openalex.org/W1930073633
  • https://openalex.org/W1963766633
  • https://openalex.org/W1964236838
  • https://openalex.org/W1966168105
  • https://openalex.org/W1968436319
  • https://openalex.org/W1970815880
  • https://openalex.org/W1971205185
  • https://openalex.org/W1975801129
  • https://openalex.org/W1976251488
  • https://openalex.org/W1980786713
  • https://openalex.org/W1982453454
  • https://openalex.org/W1982519328
  • https://openalex.org/W1985094790
  • https://openalex.org/W1986097686
  • https://openalex.org/W1989199068
  • https://openalex.org/W1989268226
  • https://openalex.org/W1991208631
  • https://openalex.org/W1991246477
  • https://openalex.org/W1997510672
  • https://openalex.org/W1997671476
  • https://openalex.org/W1997911081
  • https://openalex.org/W1998000745
  • https://openalex.org/W1998275595
  • https://openalex.org/W2001487156
  • https://openalex.org/W2002195787
  • https://openalex.org/W2002245685
  • https://openalex.org/W2003019920
  • https://openalex.org/W2004391265
  • https://openalex.org/W2005268742
  • https://openalex.org/W2005981263
  • https://openalex.org/W2007332095
  • https://openalex.org/W2007925044
  • https://openalex.org/W2007938731
  • https://openalex.org/W2007990824
  • https://openalex.org/W2008597649
  • https://openalex.org/W2008654807
  • https://openalex.org/W2010946024
  • https://openalex.org/W2011105228
  • https://openalex.org/W2011244203
  • https://openalex.org/W2012095573
  • https://openalex.org/W2012588421
  • https://openalex.org/W2013362232
  • https://openalex.org/W2014260661
  • https://openalex.org/W2015371826
  • https://openalex.org/W2016770411
  • https://openalex.org/W2017892333
  • https://openalex.org/W2021443622
  • https://openalex.org/W2021708267
  • https://openalex.org/W2024044717
  • https://openalex.org/W2025019393
  • https://openalex.org/W2025175138
  • https://openalex.org/W2025373842
  • https://openalex.org/W2028519409
  • https://openalex.org/W2029189334
  • https://openalex.org/W2030097812
  • https://openalex.org/W2030180304
  • https://openalex.org/W203085187
  • https://openalex.org/W2033106565
  • https://openalex.org/W2034868284
  • https://openalex.org/W2036918981
  • https://openalex.org/W2038099088
  • https://openalex.org/W2038279322
  • https://openalex.org/W2039596329
  • https://openalex.org/W2044045263
  • https://openalex.org/W2044580862
  • https://openalex.org/W2044740725
  • https://openalex.org/W2046188044
  • https://openalex.org/W2046571199
  • https://openalex.org/W2047156985
  • https://openalex.org/W2048445979
  • https://openalex.org/W2048938503
  • https://openalex.org/W2049061878
  • https://openalex.org/W2050527114
  • https://openalex.org/W2051243541
  • https://openalex.org/W2052264640
  • https://openalex.org/W2052287801
  • https://openalex.org/W2053052232
  • https://openalex.org/W2053125671
  • https://openalex.org/W2055224414
  • https://openalex.org/W2057573148
  • https://openalex.org/W2059633037
  • https://openalex.org/W2060037483
  • https://openalex.org/W2060610804
  • https://openalex.org/W2062298786
  • https://openalex.org/W2062366330
  • https://openalex.org/W2063058007
  • https://openalex.org/W2065764124
  • https://openalex.org/W2067181732
  • https://openalex.org/W2068107832
  • https://openalex.org/W2068228017
  • https://openalex.org/W2068929498
  • https://openalex.org/W2072016770
  • https://openalex.org/W2073133225
  • https://openalex.org/W2073882423
  • https://openalex.org/W2074432289
  • https://openalex.org/W2076179697
  • https://openalex.org/W2078046763
  • https://openalex.org/W2079067885
  • https://openalex.org/W2079751097
  • https://openalex.org/W2079994631
  • https://openalex.org/W2081984658
  • https://openalex.org/W2084399551
  • https://openalex.org/W2085124463
  • https://openalex.org/W2086697336
  • https://openalex.org/W2086871852
  • https://openalex.org/W2089082314
  • https://openalex.org/W2089248014
  • https://openalex.org/W2089315357
  • https://openalex.org/W2091451666
  • https://openalex.org/W2092358120
  • https://openalex.org/W2092900546
  • https://openalex.org/W2093414824
  • https://openalex.org/W2094558395
  • https://openalex.org/W2094753012
  • https://openalex.org/W2095537212
  • https://openalex.org/W2095547457
  • https://openalex.org/W2097483036
  • https://openalex.org/W2098522805
  • https://openalex.org/W2100261377
  • https://openalex.org/W2101037767
  • https://openalex.org/W2105582142
  • https://openalex.org/W2107759391
  • https://openalex.org/W2109356273
  • https://openalex.org/W2110670037
  • https://openalex.org/W2111579582
  • https://openalex.org/W2112181087
  • https://openalex.org/W2113504375
  • https://openalex.org/W2114589605
  • https://openalex.org/W2119963782
  • https://openalex.org/W2120987567
  • https://openalex.org/W2128277463
  • https://openalex.org/W2130337837
  • https://openalex.org/W2132254923
  • https://openalex.org/W2133151251
  • https://openalex.org/W2134162261
  • https://openalex.org/W2134513269
  • https://openalex.org/W2135268524
  • https://openalex.org/W2140298451
  • https://openalex.org/W2142017607
  • https://openalex.org/W2142373414
  • https://openalex.org/W2143578597
  • https://openalex.org/W2146101502
  • https://openalex.org/W2146636800
  • https://openalex.org/W2146752492
  • https://openalex.org/W2148264154
  • https://openalex.org/W2148622539
  • https://openalex.org/W2148779404
  • https://openalex.org/W2150547407
  • https://openalex.org/W2152390002
  • https://openalex.org/W2155814762
  • https://openalex.org/W2157450482
  • https://openalex.org/W2157740207
  • https://openalex.org/W2158110584
  • https://openalex.org/W2158199077
  • https://openalex.org/W2158324037
  • https://openalex.org/W2158854302
  • https://openalex.org/W2159406166
  • https://openalex.org/W2160384550
  • https://openalex.org/W2160833615
  • https://openalex.org/W2162667045
  • https://openalex.org/W2164092307
  • https://openalex.org/W2164942621
  • https://openalex.org/W2165787609
  • https://openalex.org/W2168469696
  • https://openalex.org/W2168479617
  • https://openalex.org/W2170187477
  • https://openalex.org/W2171151613
  • https://openalex.org/W2171433869
  • https://openalex.org/W2172147964
  • https://openalex.org/W2172466148
  • https://openalex.org/W2175029576
  • https://openalex.org/W2212574367
  • https://openalex.org/W2235741511
  • https://openalex.org/W2279007355
  • https://openalex.org/W2306482506
  • https://openalex.org/W2329488906
  • https://openalex.org/W2332934002
  • https://openalex.org/W2353444611
  • https://openalex.org/W2378261169
  • https://openalex.org/W2523207363
  • https://openalex.org/W2561872855
  • https://openalex.org/W2587941297
  • https://openalex.org/W2596585859
  • https://openalex.org/W4229597922
  • https://openalex.org/W4235073153
  • https://openalex.org/W4236846682
  • https://openalex.org/W4255409714