Published November 1, 2021 | Version v1
Publication Metadata-only

Accelerated developmental adipogenesis programs adipose tissue dysfunction and cardiometabolic risk in offspring born to dams with metabolic dysfunction

Creators

  • 1. Alberta Children's Hospital
  • 2. University of Calgary
  • 3. Cairo University
  • 4. Libin Cardiovascular Institute of Alberta
  • 5. Medical University of South Carolina

Description

This study reveals that accelerated adipogenesis during the perinatal window of adipose tissue development predisposes to later life hypertrophic adipocyte dysfunction, thereby compromising the buffering function of the subcutaneous depot.

⚠️ This is an automatic machine translation with an accuracy of 90-95%

Translated Description (Arabic)

تكشف هذه الدراسة أن التولد الشحمي المتسارع خلال النافذة المحيطة بالولادة لتطور الأنسجة الدهنية يؤهب لخلل وظيفي في الخلايا الشحمية الضخامية في وقت لاحق من الحياة، مما يضر بوظيفة التخزين المؤقت للمستودع تحت الجلد.

Translated Description (French)

Cette étude révèle que l'adipogenèse accélérée pendant la fenêtre périnatale du développement du tissu adipeux prédispose au dysfonctionnement adipocytaire hypertrophique plus tard dans la vie, compromettant ainsi la fonction tampon du dépôt sous-cutané.

Translated Description (Spanish)

Este estudio revela que la adipogénesis acelerada durante la ventana perinatal del desarrollo del tejido adiposo predispone a una disfunción hipertrófica de los adipocitos en la vida posterior, comprometiendo así la función amortiguadora del depósito subcutáneo.

Additional details

Additional titles

Translated title (Arabic)
برامج تكوين الدهون التنموية المتسارعة ضعف الأنسجة الدهنية ومخاطر القلب والأيض في النسل المولود للسدود مع خلل وظيفي استقلابي
Translated title (French)
Programmes d'adipogenèse à développement accéléré dysfonctionnement du tissu adipeux et risque cardiométabolique chez les enfants nés de mères souffrant de dysfonctionnement métabolique
Translated title (Spanish)
Programas de adipogénesis acelerada del desarrollo, disfunción del tejido adiposo y riesgo cardiometabólico en crías nacidas de madres con disfunción metabólica

Identifiers

Other
https://openalex.org/W3198447284
DOI
10.1152/ajpendo.00229.2021

Is supplement to
https://openalex.org/W3160140598 (Other)
https://openalex.org/W2167541966 (Other)
https://openalex.org/W2158864582 (Other)
https://openalex.org/W2110681150 (Other)
https://openalex.org/W2081564223 (Other)
https://openalex.org/W2064652474 (Other)
https://openalex.org/W2049045125 (Other)
https://openalex.org/W2009428258 (Other)
https://openalex.org/W1964688190 (Other)
https://openalex.org/W1591616590 (Other)

GreSIS Basics Section

Is Global South Knowledge
Yes
Country
Egypt

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