Published September 30, 2023 | Version v1
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DIAGNOSTIC ACCURACY OF CONTRAST ENHANCED T2 FLAIR IN DIAGNOSING INFECTIVE MENINGITIS CONSIDERING CSF ANALYSIS AS GOLD STANDARD

Creators

  • 1. King Edward Medical University
  • 2. Indira Gandhi Government Medical College & Hospital
  • 3. Allama Iqbal Medical College
  • 4. Mayo Hospital

Description

OBJECTIVE: To determine diagnostic accuracy of contrast enhanced T2 FLAIR in diagnosing infective meningitis considering CSF analysis as gold standard. METHODS: A prospective study of 101 patients with clinical suspicion of meningitis, referred to the radiology department of Mayo Hospital Lahore for MRI examination was done. Patients with reduced renal function, claustrophobia and metallic implants were excluded from the study. The MRI brain with contrast including postcontrast T1WI and FLAIR sequences was performed at 1.5 T machine. The images then evaluated by the competent experienced radiologists. Cerebrospinal fluid (CSF) analysis of the patients was done through lumbar puncture and was considered the "gold standard" against which comparison of MRI findings was done. Data analysis was done by using SPSS 23. RESULTS: Sensitivity and specificity of contrast enhanced T2 FLAIR MRI in detecting infective meningitis was 95.08% (CI-95%: 86.51-98.31) and 82.5% (CI-95%: 68.05, 91.25). While positive predictive value and negative predictive value was 89.23% (CI-95%: 79.4, 94.68) and 91.67% (CI-95%: 78.17, 97.13) respectively. Diagnostic accuracy was 90.1% respectively. CONCLUSION: Results of this study showed higher sensitivity and specificity for contrast enhanced T2 FLAIR in diagnosing infective meningitis. So use of contrast enhanced T2 FLAIR can be helpful in early screening and diagnosis of meningeal infections.

⚠️ This is an automatic machine translation with an accuracy of 90-95%

Translated Description (Arabic)

الهدف: تحديد الدقة التشخيصية لذوق T2 المحسن للتباين في تشخيص التهاب السحايا المعدي مع الأخذ في الاعتبار تحليل السائل النخاعي كمعيار ذهبي. الطرق: أجريت دراسة استباقية على 101 مريض يشتبه سريريًا في إصابتهم بالتهاب السحايا، وتمت إحالتهم إلى قسم الأشعة في مستشفى مايو لاهور لفحص التصوير بالرنين المغناطيسي. تم استبعاد المرضى الذين يعانون من انخفاض وظائف الكلى ورهاب الأماكن المغلقة والغرسات المعدنية من الدراسة. تم إجراء التصوير بالرنين المغناطيسي للدماغ مع التباين بما في ذلك T1WI بعد التباين وتسلسل الذوق في جهاز 1.5 T. ثم يتم تقييم الصور من قبل أخصائيي الأشعة ذوي الخبرة المختصين. تم تحليل السائل الدماغي الشوكي (CSF) للمرضى من خلال البزل القطني واعتبر "المعيار الذهبي" الذي تم على أساسه مقارنة نتائج التصوير بالرنين المغناطيسي. تم إجراء تحليل البيانات باستخدام SPSS 23. النتائج: كانت حساسية وخصوصية التصوير بالرنين المغناطيسي المعزز للتباين T2 FLAIR في الكشف عن التهاب السحايا المعدي 95.08 ٪ (CI -95 ٪: 86.51-98.31) و 82.5 ٪ (CI -95 ٪: 68.05، 91.25). في حين كانت القيمة التنبؤية الإيجابية والقيمة التنبؤية السلبية 89.23 ٪ (CI -95 ٪: 79.4، 94.68) و 91.67 ٪ (CI -95 ٪: 78.17، 97.13) على التوالي. كانت دقة التشخيص 90.1 ٪ على التوالي. الاستنتاج: أظهرت نتائج هذه الدراسة حساسية وخصوصية أعلى لذوق T2 المعزز للتباين في تشخيص التهاب السحايا المعدي. وبالتالي، يمكن أن يكون استخدام ذوق T2 المحسن للتباين مفيدًا في الفحص والتشخيص المبكر للعدوى السحائية.

Translated Description (English)

OBJECTIVE: To determine diagnostic accuracy of contrast enhanced T2 FLAIR in diagnosing infective meningitis considering CSF analysis as gold standard. METHODS: A prospective study of 101 patients with clinical suspicion of meningitis, referred to the radiology department of Mayo Hospital Lahore for MRI examination was done. Patients with reduced renal function, claustrophobia and metallic implants were excluded from the study. The MRI brain with contrast including post-contrast T1WI and FLAIR sequences was performed at 1.5 T machine. The images are then evaluated by the competent experienced radiologists. Cerebrospinal fluid (CSF) analysis of the patients was done through lumbar puncture and was considered the "gold standard" against which comparison of MRI findings was done. Data analysis was done by using SPSS 23. RESULTS: Sensitivity and specificity of contrast enhanced T2 FLAIR MRI in detecting infective meningitis was 95.08% (CI-95%: 86.51-98.31) and 82.5% (CI-95%: 68.05, 91.25). While positive predictive value and negative predictive value were 89.23% (CI-95%: 79.4, 94.68) and 91.67% (CI-95%: 78.17, 97.13) respectively. Diagnostic accuracy was 90.1% respectively. CONCLUSION: Results of this study showed higher sensitivity and specificity for contrast enhanced T2 FLAIR in diagnosing infective meningitis. Thus, use of contrast enhanced T2 FLAIR can be helpful in early screening and diagnosis of meningeal infections.

Translated Description (French)

OBJECTIF : Pour déterminer l'exactitude du diagnostic du contraste amélioré du FLAIR T2 dans le diagnostic de la méningite infectieuse, considérer l'analyse du LCR comme une norme d'or. MÉTHODES : Une étude prospective de 101 patients atteints de suspicion clinique de méningite, référencée au département de radiologie de l'hôpital Mayo de Lahore pour l'examen par IRM a été réalisée. Les patients présentant une fonction rénale réduite, une claustrophobie et des implants métalliques ont été exclus de l'étude. Le cerveau IRM avec contraste including postcontrast T1WI and FLAIR sequences was performed at 1.5 T machine. The images then evaluated by the competent experienced radiologists. L'analyse du fluide cérébrospinal (LCR) des patients a été réalisée par ponction lombaire et a pris en compte la « norme d'or » contre la comparaison des résultats d'IRM. Data analysis was done by using SPSS 23. RESULTS : Sensitivity and specificity of contrast enhanced T2 FLAIR MRI in detecting infective meningitis was 95.08% (CI-95% : 86.51-98.31) and 82.5% (CI-95% : 68.05, 91.25). While positive predictive value and negative predictive value was 89.23% (CI-95% : 79.4, 94.68) and 91.67% (CI-95% : 78.17, 97.13) respectivement. L'exactitude du diagnostic était de 90,1 % respectivement. CONCLUSION : les résultats de cette étude montrent une sensibilité et une spécificité plus élevées pour le contraste amélioré du FLAIR T2 dans le diagnostic de la méningite infectieuse. Donc use of contrast enhanced T2 FLAIR can be helpful in early screening and diagnosis of meningeal infections.

Translated Description (Spanish)

OBJECTIVE: To determine diagnostic accuracy of contrast enhanced T2 FLAIR in diagnosing infective meningitis considering CSF analysis as gold standard. METHODS: A prospective study of 101 patients with clinical suspicion of meningitis, referred to the radiology department of Mayo Hospital Lahore for MRI examination was done. Patients with reduced renal function, claustrophobia and metallic implants were excluded from the study. The MRI brain with contrast including postcontrast T1WI and FLAIR sequences was performed at 1.5 T machine. The images then evaluated by the competent experienced radiologists. El análisis del líquido cefalorraquídeo (LCR) de los pacientes se realizó a través de la punción lumbar y se consideró el «estándar de oro» contra la comparación de hallazgos de resonancia magnética. Data analysis was done by using SPSS 23. RESULTS: Sensitivity and specificity of contrast enhanced T2 FLAIR MRI in detecting infective meningitis was 95.08% (CI-95%: 86.51-98.31) and 82.5% (CI-95%: 68.05, 91.25). While positive predictive value and negative predictive value was 89.23% (CI-95%: 79.4, 94.68) and 91.67% (CI-95%: 78.17, 97.13) respectivamente. Diagnostic accuracy was 90.1% respectively. CONCLUSION: Results of this study showed higher sensitivity and specificity for contrast enhanced T2 FLAIR in diagnosing infective meningitis. So use of contrast enhanced T2 FLAIR can be helpful in early screening and diagnosis of meningeal infections.

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Additional details

Additional titles

Translated title (Arabic)
الدقة التشخيصية للتباين تعزز ذوق T2 في تشخيص التهاب السحايا المعدي مع الأخذ في الاعتبار تحليل السائل النخاعي كمعيار ذهبي
Translated title (English)
DIAGNOSTIC ACCURACY OF CONTRAST ENHANCED T2 FLAIR IN DIAGNOSING INFECTIVE MENINGITIS CONSIDERING CSF ANALYSIS AS GOLD STANDARD
Translated title (French)
DIAGNOSTIC ACCURACY OF CONTRAST ENHANCED T2 FLAIR IN DIAGNOSTIC INFECTIVE MENINGITIS CONSIDERING CSF ANALYSIS AS GOLD STANDARD
Translated title (Spanish)
DIAGNOSTIC ACCURACY OF CONTRAST ENHANCED T2 FLAIR IN DIAGNOSING INFECTIVE MENINGITIS CONSIDERING CSF ANALYSIS AS GOLD STANDARD

Identifiers

Other
https://openalex.org/W4387234066
DOI
10.51642/ppmj.v34i03.606

Is supplement to
https://openalex.org/W4252743855 (Other)
https://openalex.org/W4205470901 (Other)
https://openalex.org/W2899022551 (Other)
https://openalex.org/W2804273997 (Other)
https://openalex.org/W2406224619 (Other)
https://openalex.org/W2162119169 (Other)
https://openalex.org/W2102553615 (Other)
https://openalex.org/W2088750112 (Other)
https://openalex.org/W2061169681 (Other)
https://openalex.org/W1984356223 (Other)

GreSIS Basics Section

Is Global South Knowledge
Yes
Country
Pakistan