Published January 29, 2012 | Version v1
Publication Open

Lipase Catalysed Kinetic Resolution of Stiripentol

Creators

  • 1. Norwegian University of Science and Technology
  • 2. TrønderEnergi (Norway)
  • 3. National Research Centre
  • 4. Cairo University

Description

Kinetic resolution of rac-Stiripentol, catalysed by lipase A from Candida antarctica by esterification with vinyl butanoate was performed with an E-value of 24.This allowed isolation of (3S)-Stiripentol with an ee of 86 % and the corresponding (3R)-butanoate with an ee of 87 %.Enzymatic hydrolysis of the ester product gave (3R)-

⚠️ This is an automatic machine translation with an accuracy of 90-95%

Translated Description (Arabic)

تم إجراء التحليل الحركي لـ rac - Stiripentol، المحفز بواسطة lipase A من المبيضات في القارة القطبية الجنوبية عن طريق الأسترة باستخدام بوتانوات الفينيل بقيمة E قدرها 24. وقد سمح هذا بعزل (3S) - Stiripentol مع ee بنسبة 86 ٪ و (3R) - butanoate المقابلة مع ee بنسبة 87 ٪. التحلل المائي الأنزيمي لمنتج الإستر المعطى (3R)-

Translated Description (French)

La résolution cinétique du rac-Stiripentol, catalysé par la lipase A de Candida antarctica par estérification avec du butanoate de vinyle a été effectuée avec une valeur E de 24. Cela a permis d'isoler le (3S) -Stiripentol avec un Ee de 86 % et le (3R)-butanoate correspondant avec un Ee de 87 %. L'hydrolyse enzymatique du produit ester a donné (3R)-

Translated Description (Spanish)

La resolución cinética de rac-estiripentol, catalizada por la lipasa A de Candida antarctica por esterificación con butanoato de vinilo se realizó con un valor E de 24. Esto permitió el aislamiento de (3S) -estiripentol con un ee del 86 % y el correspondiente (3R)-butanoato con un ee del 87 %. La hidrólisis enzimática del producto éster dio (3R)-

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Additional details

Additional titles

Translated title (Arabic)
الدقة الحركية المحفزة لليباز من ستيريبينتول
Translated title (French)
Résolution cinétique du stiripentol catalysée par la lipase
Translated title (Spanish)
Resolución cinética del estiripentol catalizada por lipasa

Identifiers

Other
https://openalex.org/W2111606190
DOI
10.5539/ijc.v4n1p7

Is supplement to
https://openalex.org/W2973151342 (Other)
https://openalex.org/W2953067539 (Other)
https://openalex.org/W2461674636 (Other)
https://openalex.org/W2203350573 (Other)
https://openalex.org/W2107111345 (Other)
https://openalex.org/W2097472442 (Other)
https://openalex.org/W2068623161 (Other)
https://openalex.org/W2066569436 (Other)
https://openalex.org/W2056156726 (Other)
https://openalex.org/W1559365014 (Other)

GreSIS Basics Section

Is Global South Knowledge
Yes
Country
Egypt

References

  • https://openalex.org/W1976464947
  • https://openalex.org/W1978501441
  • https://openalex.org/W1981676656
  • https://openalex.org/W1994224697
  • https://openalex.org/W2006784982
  • https://openalex.org/W2016217788
  • https://openalex.org/W2026117532
  • https://openalex.org/W2027650622
  • https://openalex.org/W2062429421
  • https://openalex.org/W4230784343
  • https://openalex.org/W4250399651