Published July 28, 2017 | Version v1
Publication Open

An overview of comparative modelling and resources dedicated to large-scale modelling of genome sequences

Creators

  • 1. National University of Malaysia
  • 2. Institute of Structural and Molecular Biology
  • 3. University College London

Description

Computational modelling of proteins has been a major catalyst in structural biology. Bioinformatics groups have exploited the repositories of known structures to predict high-quality structural models with high efficiency at low cost. This article provides an overview of comparative modelling, reviews recent developments and describes resources dedicated to large-scale comparative modelling of genome sequences. The value of subclustering protein domain superfamilies to guide the template-selection process is investigated. Some recent cases in which structural modelling has aided experimental work to determine very large macromolecular complexes are also cited.

⚠️ This is an automatic machine translation with an accuracy of 90-95%

Translated Description (Arabic)

كانت النمذجة الحسابية للبروتينات حافزًا رئيسيًا في البيولوجيا الهيكلية. استغلت مجموعات المعلوماتية الحيوية مستودعات الهياكل المعروفة للتنبؤ بالنماذج الهيكلية عالية الجودة بكفاءة عالية بتكلفة منخفضة. تقدم هذه المقالة لمحة عامة عن النمذجة المقارنة، وتستعرض التطورات الأخيرة وتصف الموارد المخصصة للنمذجة المقارنة واسعة النطاق لتسلسلات الجينوم. يتم التحقيق في قيمة المجموعات الفرعية لمجال البروتين لتوجيه عملية اختيار القالب. كما تم الاستشهاد ببعض الحالات الحديثة التي ساعدت فيها النمذجة الهيكلية في العمل التجريبي لتحديد المجمعات الجزيئية الكبيرة جدًا.

Translated Description (French)

La modélisation informatique des protéines a été un catalyseur majeur en biologie structurelle. Les groupes de bioinformatique ont exploité les référentiels de structures connues pour prédire des modèles structurels de haute qualité avec une grande efficacité à faible coût. Cet article donne un aperçu de la modélisation comparative, passe en revue les développements récents et décrit les ressources dédiées à la modélisation comparative à grande échelle des séquences du génome. La valeur des superfamilles de domaine protéique de sous-classement pour guider le processus de sélection de modèle est étudiée. Certains cas récents dans lesquels la modélisation structurelle a aidé les travaux expérimentaux pour déterminer de très grands complexes macromoléculaires sont également cités.

Translated Description (Spanish)

El modelado computacional de proteínas ha sido un catalizador importante en la biología estructural. Los grupos de bioinformática han explotado los repositorios de estructuras conocidas para predecir modelos estructurales de alta calidad con alta eficiencia a bajo costo. Este artículo proporciona una visión general de la modelización comparativa, revisa los desarrollos recientes y describe los recursos dedicados a la modelización comparativa a gran escala de las secuencias del genoma. Se investiga el valor de la subagrupación de superfamilias de dominios de proteínas para guiar el proceso de selección de plantillas. También se citan algunos casos recientes en los que la modelización estructural ha ayudado al trabajo experimental para determinar complejos macromoleculares muy grandes.

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Additional details

Additional titles

Translated title (Arabic)
نظرة عامة على النمذجة المقارنة والموارد المخصصة للنمذجة واسعة النطاق لتسلسلات الجينوم
Translated title (French)
Un aperçu de la modélisation comparative et des ressources dédiées à la modélisation à grande échelle des séquences génomiques
Translated title (Spanish)
Una descripción general de la modelización comparativa y los recursos dedicados a la modelización a gran escala de las secuencias del genoma

Identifiers

Other
https://openalex.org/W2740279634
DOI
10.1107/s2059798317008920

Is supplement to
https://openalex.org/W4205762803 (Other)
https://openalex.org/W2535856026 (Other)
https://openalex.org/W2468698815 (Other)
https://openalex.org/W2383516975 (Other)
https://openalex.org/W2374878784 (Other)
https://openalex.org/W2371642785 (Other)
https://openalex.org/W2322875716 (Other)
https://openalex.org/W2265065644 (Other)
https://openalex.org/W2147679489 (Other)
https://openalex.org/W2134699697 (Other)

GreSIS Basics Section

Is Global South Knowledge
Yes
Country
Malaysia

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